Immunoglobulin Levels, Opsonic Activity and Phagocytic Power in Egyptian Thalassemic Children

Khalifa, Ahmad Abdelzaher Zaki; Fattah, Saadia Abdel; Maged, Z; Sabry, Fadila; Mohamed, Hayam Ahmed

doi:10.1159/000206875

Cited by 11 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been attributed to viral stimulation or cell transformation by known or unknown agents. The intensive polyclonal B-cell activation found in vivo in thalassemia is in accordance with elevated levels of serum immunoglobulins reported in this disease [21]. Although the number of spontaneous PFC was elevated in thalassemic patients, their lymphocytes when induced by PWM differentiated to immunoglobulin-secreting cells in a lesser number than in the controls.…”

Section: Discussionsupporting

confidence: 85%

Effect of alpha interferon on the altered t‐b‐cell immunoregulation in patients with thalassemia major

et al. 1987

View full text Add to dashboard Cite

We studied the ability of B-lymphocytes to differentiate to immunoglobulin-producing cells in 14 patients with thalassemia major, 11 parents of the patients, and 86 normal subjects. In comparison with the parents of the patients and with the normal individuals, the patients were found to have 1) an increased number of cells spontaneously secreting immunoglobulin; 2) a decreased number of plaque-forming cells (PFC) when induced with pokeweed mitogen (PWM) and a deficient helper T-cell function for the induction of B-cell differentiation; 3) an increase in the number of PFC after the addition of alpha interferon (100 IU/ml) to the cell cultures with PWM. Previous incubation of non-T-cells with alpha interferon for 1 hr and subsequent coculture with T-cells from the same patients or from normal subjects in the presence of PWM increased the number of PFC. On the contrary, previous incubation of T-cells with alpha interferon followed by coculture with normal non-T-cells or cells from the same patient did not modify the number of PFC. These results suggest that patients with thalassemia major possess hyperreactive spontaneous B-cell responses and that these B-cells are unable to differentiate to immunoglobulin-secreting cells in the presence of PWM. This would be due to a T-helper-cell deficiency with an inability to produce lymphokines (interferon being one of them), while the B-cell function seems to remain intrinsically intact.

show abstract

Section: Discussionsupporting

confidence: 85%

Effect of alpha interferon on the altered t‐b‐cell immunoregulation in patients with thalassemia major

et al. 1987

View full text Add to dashboard Cite

show abstract

“…The hypergammaglobulinemia en countered in these patients can be explained partly by the increased help provided by T helper cells to B lymphocytes and partly by the hyperplasia of the reti culoendothelial system which was reported by Khal ifa et al [4]. Delayed cutaneous hypersensitivity reac tions and the ability to release the MIF were found to be the same in beta-thalassemia major trait and in normal controls.…”

Section: Discussionsupporting

confidence: 56%

“…Splenectomized individ uals under 3 years of age are liable to die from septi cemia, specially due to encapsulated organisms [3]. In order to clarify factors making thalassemic patients more susceptible to infections, Khalifa et al [4] stud ied immunoglobulin levels, opsonizing activity and phagocytic power and the effect of splenectomy on them in patients with thalassemia. They reported in creased serum immunoglobulins (IgG, IgM and IgA).…”

Section: Introductionmentioning

confidence: 99%

T Cell Functions in Infants and Children with Beta-Thalassemia

et al. 1988

Self Cite

View full text Add to dashboard Cite

Thirty-five infants and children with beta-thalassemia major and 12 with beta-thalassemia trait were studied. Their ages ranged between 6 months and 12 years. Thirty-three were males and 14 females. Spontaneous rosette (E₁-RFC), total rosette (E₂-RFC), enumeration of T lymphocyte subsets using monoclonal antibodies (OKT₃, OKT₄, and OKT₈), migration inhibition factor (MIF) assay and in vivo delayed hypersensitivity skin reactions were tested. Lower mean T cell population was present in thalassemia major but not the trait. The helper/suppressor ratio was decreased in patients with evidence of hypersplenism. Patients who had suffered from pneumonia or hepatitis manifested lower mean T cell count, depletion of helper cells and decreased helper/suppressor ratio. They also showed depressed delayed cutaneous hypersensitivity and MIF activity. Study of the cell-mediated immunity in patients with thalassemia might be useful to detect those who could be-more susceptible to infections.

show abstract

“…Further studies have confirmed the findings about disruption of the functional activity of PMN. A study conducted in 25 patients with β-thalassemia major from Egypt has shown a decrease in phagocytic index to both salmonella and staphylococcus in patients [10]. Also found a disruption of chemotaxis and spontaneous migration of PMN in β-thalassemia major [11,12].…”

Section: Introductionmentioning

confidence: 99%

mmunologic Abnormalities in β-Thalassemia

Asadov¹

2014

J Blood Disord Transfus

View full text Add to dashboard Cite

Immunoglobulin Levels, Opsonic Activity and Phagocytic Power in Egyptian Thalassemic Children

Cited by 11 publications

References 6 publications

Effect of alpha interferon on the altered t‐b‐cell immunoregulation in patients with thalassemia major

Effect of alpha interferon on the altered t‐b‐cell immunoregulation in patients with thalassemia major

T Cell Functions in Infants and Children with Beta-Thalassemia

mmunologic Abnormalities in β-Thalassemia

Contact Info

Product

Resources

About