Immunoglobulins and Antibodies in Plaque Fluid and Saliva in Two Populations with Contrasting Levels of Caries

Cole, Michael F.; Bowen, William H.; Sierra, Ligia; Espinal, F; Aguirra, M.; Kingman, Albert; Kemp, Lindsay J.; Gómez, I.; Reilly, J.; Hsu, Di-Hwel; Ciardi, J.E.; Gillespie, G. Yancey

doi:10.1007/978-1-4684-3369-2_43

Cited by 13 publications

(2 citation statements)

References 26 publications

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“…The fate of a specific salivary component once secreted into the oral cavity depends on its susceptibility to enzymatic attack, especially in the face of the numerous bacterial hydrolytic enzymes present in saliva (Nakamura and Slots, 1983;Zambon et al, (Mandel, 1980); amylase (Aguirre et al, 1987); cystatin (Aguirre et al, 1992); fibronectin (Babu and Dabbous, 1986;Tynelius-Bratthall et al, 1986); histatins (MacKay et al, 1984b); IgG (Cole et aL., 1978;Mandel, 1980); lactoferrin (Mandel, 1980;Rudney et al, 1991); lysozyme (Mandel, 1980;Rudney et al, 1991); MG2 (Aguirre et aL., 1993); f-2-microglobulin (Ericson et al, 1982); parotid agglutinin (Ericson and Rundegren, 1983); proline-rich proteins (Hay and Moreno, 1987;Kousvelari et al, 1980, Aguirre et al, 1993; sigA (Aguirre et al, 1987;Cole et al, 1978;Rudney et al, 1991;Stuchell and Mandel, 1978); statherin (Hay et al, 1984); transferrin (Mandel, 1980 . Unfortunately, little information exists regarding the susceptibility of individual salivary proteins to proteolytic degradation in the oral environment.…”

Section: The Interaction Of Salivary Components With the Bacterialmentioning

confidence: 99%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

286

250

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Saliva is thought to have a significant impact on the colonization of microorganisms in the oral cavity. Salivary components may participate in this process by one of four general mechanisms: binding to microorganisms to facilitate their clearance from the oral cavity, serving as receptors in oral pellicles for microbial adhesion to host surfaces, inhibiting microbial growth or mediating microbial killing, and serving as microbial nutritional substrates. This article reviews information pertinent to the molecular interaction of salivary components with bacteria (primarily the oral streptococci and Actinomyces) and explores the implications of these interactions for oral bacterial colonization and dental plaque formation. Knowledge of the molecular mechanisms controlling bacterial colonization of the oral cavity may suggest methods to prevent not only dental plaque formation but also serious medical infections that may follow microbial colonization of the oral cavity.

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Section: The Interaction Of Salivary Components With the Bacterialmentioning

confidence: 99%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

286

250

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“…Salivary antibodies apparently have a protective function, perhaps including the prevention of caries (2,8, 10,14,19,28,30). Several authors have studied the concentrations of human salivary immunoglobulins, but the findings have been variable, especially the values of IgG and IgM.…”

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confidence: 99%

Concentration of immunoglobulins in human whole saliva: Effect of physiological stimulation

Grönblad¹

1982

Acta Odontologica Scandinavica

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The concentrations of total protein, albumin, IgA, IgG and IgM in human whole salivas were measured with a solid phase radioimmunoassay before and after physiological stimulation of salivary secretion. The geometric mean concentrations (mg/l) before stimulation were: total protein 1600, albumin 60, IgA 140, IgG 16 and IgM 4.1. Physiological stimulation of salivary secretion caused an increase of the total protein concentration to 2400 mg/l, had little effect on the concentrations of albumin and IgG, but lowered the concentrations of IgA and IgM to 56 mg/l and 1.7 mg/l, respectively. These findings indicate that a considerable portion of salivary IgA and IgM are produced locally depending on selective transport and that the release from local storage sites is not increased during stimulation as much as the total volume of the saliva.

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