Immunohistochemical alterations in neuropeptide Y-positive nerve elements in rat cerebral cortex following acute phencyclidine treatment

Fukui, Kenji; Kawashima, Yoshiki; Iizumi, Hideyuki; Utsumi, Hirohiko; Nakajima, Teruo

doi:10.1097/00001756-199503000-00010

Cited by 4 publications

(1 citation statement)

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“…blocking of glutamatergic inhibitory regulation. Indeed, we have reported that cortical NPY neuronal system is controlled, at least partly, by glutamatergic inputs via NMDA receptor-mediated mechanisms (Fukui et al, 1995). It has been reported, however, the PCP treatment influences other neurotransmitters and their receptors such as serotonin (Nabeshima et al, 1981), GABA (Nabeshima et al, 1984) and o receptor (Junien and Leonard, 1989), further studies are necessary to confirm our findings due to the direct influence of PCP on glutamatergic or indirectly on other neurotransmitters, or both.…”

Section: Discussionmentioning

confidence: 99%

The effects of acute phencyclidine treatment on neuropeptide Y (NPY) neuronal system in the rat arcuate nucleus studied by immunocytochemistry and in situ hybridization

Fukui

Kawashima

Iizumi

et al. 1996

J. Neural Transmission

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Phencyclidine (PCP) is a dissociative drug and an antagonist of N-methyl-D-aspartate (NMDA) receptor. The effects of PCP treatment on neuropeptide Y (NPY) system in the arcuate nucleus of the rat hypothalamus were examined both by immunocytochemistry and in situ hybridization. In acute PCP-treated rats, the NPY-immunoreactive perikarya appeared in the arcuate nucleus but no perikarya were detected in controls, without colchicine pretreatment. The signals of NPY mRNA by in situ hybridization increased in the PCP-treated rats than those of controls. These results suggest that the NPY system in the arcuate nucleus might be partly controlled by glutamatergic neurons.

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Section: Discussionmentioning

confidence: 99%