To investigate an effect of indigestible polysaccharides (cellulose as control, sodium alginate, guar gum or lambda-carrageenan) on the accumulation of pentachlorobenzene, male Sprague Dawley rats were fed experimental diets containing 5 g/100 g of these polysaccharides for 2 wk. They were then given orally 80 mumol (20 mg) of pentachlorobenzene along with their respective diets and the residual pentachlorobenzene was determined after 7 d. The ingestion of the viscous indigestible polysaccharides resulted in significantly lower accumulation of pentachlorobenzene in adipose tissue, liver and kidney than that found in rats fed a cellulose diet. Soon (5 h) after pentachlorobenzene administration, its concentration in the blood of rats fed sodium alginate and guar gum was higher than that of rats fed cellulose, but lower in the groups fed all three viscous polysaccharides after d 3. These results indicate that pentachlorobenzene excretion was increased by the ingestion of viscous indigestible polysaccharides. Lower relative weight of adipose tissue, a storage tissue for pentachlorobenzene, was found in the rats fed sodium alginate and guar gum. The lower adipose tissue mass was likely the main contributor to the enhancement of pentachlorobenzene excretion.

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Phencyclidine (PCP) is a dissociative drug and an antagonist of N-methyl-D-aspartate (NMDA) receptor. The effects of PCP treatment on neuropeptide Y (NPY) system in the arcuate nucleus of the rat hypothalamus were examined both by immunocytochemistry and in situ hybridization. In acute PCP-treated rats, the NPY-immunoreactive perikarya appeared in the arcuate nucleus but no perikarya were detected in controls, without colchicine pretreatment. The signals of NPY mRNA by in situ hybridization increased in the PCP-treated rats than those of controls. These results suggest that the NPY system in the arcuate nucleus might be partly controlled by glutamatergic neurons.