Immunohistochemical analysis of mismatch proteins in carcinogenesis of the lower lip

Sarmento, Dmitry José de Santana; Almeida, Wagner Leite de; Miguel, Márcia Cristina da Costa; Queiroz, Lélia Maria Guedes; Godoy, Gustavo Pina; Cruz, Maria Carmen Fôntoura Nogueira da; Silveira, Éricka Janine Dantas da

doi:10.1111/his.12197

Cited by 14 publications

(17 citation statements)

References 29 publications

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“…MSI induces the activation of oncogenes or inactivation of tumor suppressor genes, which can initiate cellular carcinogenesis [12,26,32]. Our group have described that low immunoexpression of hMSH2 is an early event in the carcinogenesis of lower lip cancer in a previous study [33]. We found a significantly higher expression of hMSH2 in ACs with absent/mild dysplasia than in the group with moderate or severe dysplasia.…”

Section: Introductionmentioning

confidence: 56%

“…The cases were intentionally selected on basis of the histopathological diagnosis. The diagnosis of AC or SCC of the lower lip was confirmed by reviewing the clinical and histopathological data in the patient records, as performed by Sarmento et al [33].…”

Section: Tissue Specimensmentioning

confidence: 99%

“…For our previous study [33], the specimens of this sample were stained with monoclonal antibody against hMSH2. The specifications of the primary antibodies (clone, manufacturer, dilution, antigen retrieval and incubation) are shown in Table 1.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…The aim of the present study was to evaluate the epithelial immunoexpression of p53 and p21 proteins in AC and SCC of the lower lip and then analyze the relationships between these proteins and the previously reported hMSH2 expression in the same sample [33], to determine the participation of these proteins in different morphological stages of carcinogenesis lip.…”

Section: Introductionmentioning

confidence: 99%

“…Both lesions have similar characteristics with skin lesions and also share the same main etiological agent, ultraviolet (UV) radiation, particularly the UVB [33]. The carcinogenesis process induced by UV, is still not fully elucidated, but it is known that exposure to endogenous and exogenous genotoxic agents, such as UV, can lead to oncogenic mutations resulting from perturbation of the cell cycle and damage to DNA repair systems [15,30,31].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

et al. 2016

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This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann-Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson's correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p [ 0.05). Immunoexpression of p53 was higher in SCC than in AC (p \ 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = -0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.

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Section: Introductionmentioning

confidence: 56%

Section: Tissue Specimensmentioning

confidence: 99%

Section: Immunohistochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

et al. 2016

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Microsatellite Instability and Loss of Heterozygosity as Prognostic Markers in Oral Squamous Cell Carcinoma: Molecular Mechanisms, Detection Techniques, and Therapeutic Strategies

Arslan Bozdag,

Inan,

Elif Gultekin

2024

Genes Chromosomes & Cancer

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The aim of this study was to conduct a systematic review of research investigating the potential role of microsatellite instability (MSI) and loss of heterozygosity (LOH) in oral squamous cell carcinoma (OSCC), with a focus on molecular mechanisms, detection methods, and therapeutic approaches. Search for articles involved the PubMed and Scopus. Previous retrospective and prospective studies identified variations between oral cancers that exhibit microsatellite stability and LOH. In this search, 294 articles were initially retrieved. Of these, 70 were excluded due to duplication, 106 were identified as ineligible by automated tools, and 24 were excluded as they were published in languages other than English. An additional 94 articles were excluded, 32 of which focused on head and neck cancers broadly, and 8 could not be accessed due to withdrawal. Ultimately, a systematic review was conducted based on 54 selected articles. Among the chromosomes analyzed for MSI and LOH, the highest frequency of LOH was observed on chromosome 9p. The MSI subtype is particularly susceptible to immunotherapeutic methods, such as the use of anti‐PD‐L1 and anti‐CTLA4 antibodies, owing to its strong immunogenicity and ubiquitous expression of immune checkpoint ligands. Given the distinct characteristics and clinical behavior of oral cancer with MSI compared to microsatellite stable disease, it is advisable to incorporate MSI testing into the diagnostic process for all stages of tumor development. This ensured that each patient had received precise and effective treatment.

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Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study

Lopes

Gonzaga

Mosconi

et al. 2019

Archives of Oral Biology

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Immunohistochemical analysis of mismatch proteins in carcinogenesis of the lower lip

Abstract: The results support the hypothesis that changes in the immunoexpression of these mismatch proteins are related to the process of carcinogenesis of the lower lip.

Cited by 14 publications

References 29 publications

Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

Microsatellite Instability and Loss of Heterozygosity as Prognostic Markers in Oral Squamous Cell Carcinoma: Molecular Mechanisms, Detection Techniques, and Therapeutic Strategies

Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study

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