Immunohistochemical analysis of P53 protein in odontogenic cysts

Abstract

The p53 is a well-known tumor suppressor gene, the mutations of which are closely related to the decreased differentiation of cells. Findings of studies on immunohistochemical P53 expression in odontogenic cysts are controversial. The present study was carried-out to investigate the immunohistochemical expression of P53 protein in odontogenic cysts. Thirty paraffin blocks of diagnosed odontogenic cysts were processed to determine the immunohistochemical expression of P53 protein. Nine of the 11 odontogenic keratocysts (81.8%) expressed P53, one of three dentigerous cyst cases expressed P53, while none of the 16 radicular cysts expressed P53 protein. The findings of the present work supported the reclassification of OKC as keratocystic odontogenic tumor.

Saúde Bucal Auto Percebida De Adolescentes Matriculados Em Escolas Públicas No Município De Vila Velha/Es

“…A região posterior da mandíbula foi o sítio mais frequentemente encontrado neste estudo, resultado semelhante às pesquisas realizadas anteriormente, (GABALLAH;TAWFIK, 2010;CHAISUPARAT et al, 2013;JAMSHIDI;ZARGARAN;NAZHVANI, 2017). provavelmente por estar associado ao grande número de terceiros molares impactados nessa localização anatômica.…”

KAI-1 and p53 expression in odontogenic cysts: An immunohistochemical (IHC) marker study

“…The findings of the present study were in accordance with these authors as well as with the various other studies present in the literature. [20,26,27,32] Recent studies have also indicated that p53 alteration occurs at a greater frequency in invasive than in noninvasive carcinomas. [15,33] The high reactivity of p53 protein in OKCs …”

The Use of Proliferation Markers of the Infamatuar and Developmental Odontogenic Cysts

“…40 These results are also supported by other studies. 41 Nevertheless it was also reported that p53 protein is only detectable in KOTs among the jaw cysts along with a higher PCNA existence dentigerous or radicular cysts compared to KOTs. 42 Öktemer, reports higher expression of this marker may help us explain the aggressive course of KOT in comparison to other odontogenic cysts.…”