Immunohistochemical analysis of pleomorphic lobular carcinoma: higher expression of p53 and chromogranin and lower expression of ER and PgR

Jm, Radhi

doi:10.1046/j.1365-2559.2000.00810.x

Cited by 60 publications

(54 citation statements)

References 9 publications

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“…The literature shows that classic invasive lobular carcinomas, which correlate with grade I invasive lobular carcinomas are known to have a high incidence (490%) of progesterone receptor expression. [16][17][18][19] The reported incidence, however, of progesterone receptor positivity for 'pleomorphic' lobular carcinomas, corresponding to grade II and III in our study, is widely disparate, ranging from 9 to 97%. 16,18,19 HER2/neu is a proto-oncogene located on the long arm of chromosome 17.…”

Section: Discussionmentioning

confidence: 58%

“…[16][17][18][19] The reported incidence, however, of progesterone receptor positivity for 'pleomorphic' lobular carcinomas, corresponding to grade II and III in our study, is widely disparate, ranging from 9 to 97%. 16,18,19 HER2/neu is a proto-oncogene located on the long arm of chromosome 17. 45 Low levels of the protein expressed by this gene are normally present in many adult tissues including breast, endometrium, prostate and ovary.…”

Section: Discussionmentioning

confidence: 87%

“…Pleomorphic lobular carcinoma has subsequently been the subject of a number of papers [16][17][18][19] and is described under the general rubric of invasive lobular carcinoma in the new World Health Organisation Classification of Tumours. 4 Nuclear pleomorphism is only one of the features of the Nottingham combined grading system.…”

Section: Discussionmentioning

confidence: 99%

“…Yet other studies that have addressed estrogen receptor status in pleomorphic lobular carcinomas not otherwise graded, have found varying degrees of receptor positivity, 9-81%. [16][17][18] The expression of progesterone receptor also carries both prognostic and predictive information. The prognostic utility of progesterone receptor has been validated in a number of studies [39][40][41][42][43][44][45] and is thought to reflect the presence of a functional estrogen receptor pathway in the tumor and is used to predict the response of patients to adjuvant endocrine therapy.…”

Section: Discussionmentioning

confidence: 99%

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Invasive lobular carcinoma: to grade or not to grade

et al. 2005

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Grading of invasive ductal carcinoma of no special type using the Nottingham combined histologic grading system provides independent prognostic information. The prognostic utility of grading invasive lobular carcinomas, however, has not been fully elucidated. In addition, the relationship between grade in invasive lobular carcinomas and expression of predictive biomarkers is less certain. The purpose of this study was to correlate histologic grade in invasive lobular carcinoma with known prognostic and predictive markers. All primary resections for invasive mammary carcinomas diagnosed in Mount Sinai Hospital, Toronto, between the years 1996 and 2002 were reviewed (n ¼ 1053). Of these cases, 50 were pure invasive lobular carcinoma (incidence 4.7%). The median age at diagnosis was 64 years. These tumors were graded using the Nottingham combined histologic grading system and analyzed for estrogen receptor, progesterone receptor, HER2/neu and E-cadherin expression. Tumor grade was correlated with tumor size (P ¼ 0.03), and the American Joint Committee on Cancer nodal status (P ¼ 0.05). Assessment of the individual components of grade showed that the mitotic score was highly correlated with tumor size (P ¼ 0.02), lymph node positivity (P ¼ 0.02) and overall American Joint Committee on Cancer stage (P ¼ 0.01). Estrogen receptor and progesterone receptor were highly expressed irrespective of the grade of tumor. HER2/neu protein overexpression and E-cadherin protein expression was absent in all invasive lobular carcinomas studied. We conclude that pure invasive lobular carcinoma is uncommon and occurs predominantly in postmenopausal women. Increasing tumor grade is correlated with median tumor size and the American Joint Committee on Cancer nodal stage, but not correlated with the expression of estrogen receptor, progesterone receptor, E-cadherin or HER2/neu protein overexpression.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Invasive lobular carcinoma: to grade or not to grade

et al. 2005

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“…[7][8][9] Derksen et al 10 demonstrated that combined inactivation of E-cadherin and TP53 in mice induces development of invasive and metastatic mammary carcinomas, which resemble human pleomorphic lobular carcinoma. Previous studies, although limited by small numbers of patients, concluded that this subtype shows an aggressive clinical behaviour compared with classical invasive lobular carcinoma.…”

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confidence: 99%

Pleomorphic lobular carcinoma of the breast: is it a prognostically significant pathological subtype independent of histological grade?

et al. 2013

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Pleomorphic lobular carcinoma is regarded as a biologically aggressive variant of invasive lobular carcinoma of the breast. However, there is no consensus on the definition and whether this subtype adds useful information to histological grade. Two-hundred and two grade 2 or grade 3 invasive lobular carcinomas were studied. Tumours were categorised according to the components of histological grade: tubules, pleomorphism and mitoses. Pleomorphic lobular carcinoma was defined as a carcinoma with a lobular growth pattern and marked nuclear pleomorphism (pleomorphism 3). Breast cancer-specific survival was used in analysis of prognosis. Grade 3 pleomorphic lobular carcinomas (tubules 3, pleomorphism 3, mitoses 2 and tubules 3, pleomorphism 3, mitoses 3) had a worse prognosis than grade 2 (tubules 3, pleomorphism 2, mitoses 1) carcinomas. Grade 2 lobular carcinomas with marked nuclear pleomorphism (tubules 3, pleomorphism 3, mitoses 1) had a similar prognosis to grade 2 carcinomas with moderate pleomorphism (tubules 3, pleomorphism 2, mitoses 1). Survival was associated with mitotic score, but not with nuclear pleomorphism on both univariate and multivariate analysis. A non-classical growth pattern was seen more frequently in all subgroups with marked nuclear pleomorphism and was associated with worse survival. Histological grade and nodal status were independent of prognostic factors. This study shows that histological grade (in particular the mitotic component) in invasive lobular carcinomas is of prognostic importance, but pleomorphic type does not provide useful additional prognostic information.

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Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population‐based study

et al. 2017

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The purpose of this study was to explore the clinicopathological features and survival outcome of pleomorphic lobular carcinoma (PLC) of breast, we identified 131 PLC patients and 460,109 invasive ductal carcinoma (IDC) patients in the Surveillance, Epidemiology, and End Result (SEER) database. PLCs presented with increased lymph node involvement, older age, higher AJCC stage and grade, and lower median survival months (PLC 84 ± 51.03 vs. IDC 105.2 ± 64.39 P < 0.01). Compared to IDC patients, PLC patients were more inclined to be treated with mastectomy. In univariate analysis, PLC patients showed a worse disease‐specific survival (DSS) than that of IDC patients (hazard ratio = 0.691, 95% confidence interval 0.534–0.893, P < 0.01). In multivariate analysis, we took into account other prognostic factors and found that the histology types were no longer an independent prognostic factor (P = 0.120). DSS have no difference between matched IDC and PLC groups (P = 0.615). This result may be due to PLCs presenting higher tumor stage, higher tumor grade, and higher rate of LN metastasis than IDCs. Our conclusion is that PLC and IDC have many different characteristics, but there is not enough difference on the DSS.

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Immunohistochemical analysis of pleomorphic lobular carcinoma: higher expression of p53 and chromogranin and lower expression of ER and PgR

Cited by 60 publications

References 9 publications

Invasive lobular carcinoma: to grade or not to grade

Invasive lobular carcinoma: to grade or not to grade

Pleomorphic lobular carcinoma of the breast: is it a prognostically significant pathological subtype independent of histological grade?

Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population‐based study

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