Immunohistochemical and immunoelectron microscopic study of an amylase-producing, CA19-9 positive ovarian mucinous cystadenocarcinoma

Teshima, Hideo; Kitamura, Hirokazu; Mizoguchi, Youichi; Hino, Shuichiro; Mizutani, Katsumi; Mori, Hiroyuki; Kigawa, Tomonori

doi:10.1016/0090-8258(88)90251-x

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Paraneoplastic production of amylase activity is an un common phenomenon described in tumors of lung, ovary, breast, uterus, stomach and bone [1][2][3][4][5][6]. Ectopic amylase production is even rarer, with only 8 patients with multiple myeloma (MM) [7][8][9][10] and 1 more with monoclonal gammapathy of undetermined significance [11 ] being reported.…”

Section: Introductionmentioning

confidence: 99%

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

López

Ulibarrena²,

González-Porqué³

et al. 1993

Acta Haematol

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Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a possible pancreatitis made us suspect the diagnosis. Amylase production was observed in bone marrow cultures in which 96% of cellularity was composed of plasmablasts. Serum amylase level decreased when chemotherapy was given.

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Section: Introductionmentioning

confidence: 99%

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

López

Ulibarrena²,

González-Porqué³

et al. 1993

Acta Haematol

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“…In those reports [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46], in 1988, Henriksen and Brock had been already reported about "fastmigrated amylase isoenzymes" in the patient's serum, cyst fluid, and tumor tissue. They reported that electrophoretic separation of the amylase revealed fast-migration forms in serum 10 of 47 (21.3%) patients with malignant ovarian neoplasms.…”

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confidence: 99%

“…Many investigators have reported amylase-producing ovarian cancer and reported that serum amylase is an important tumor marker [15,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. In particular, amylase isoenzyme electrophoresis has been helpful [6,32] in making an early diagnosis and distinguishing from pancreatitis; the amylase phenotype was generally salivary.…”

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confidence: 99%

Sialyl Salivary–Type Amylase Associated with Ovarian Cancer

Moriyama¹

2013

Cancer Treatment - Conventional and Innovative Approaches

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The criteria were: a S3 to S2 ratio of over 1.0 and/or acidic fast-migrated sub-bands from S4 to S6. The sera were stored at-80ºC until required. A sample with a normal amylase isoenzyme electrophoretic pattern was used as control in the analyses of neuraminidase treatment, reaction with anti-salivary monoclonal antibody, and size-exclusion HPLC. 2.2. Measurement of total amylase activity Total serum amylase activity was measured on a Hitachi 7170 automated analyzer with G4-CNP as substrate (Toyobo, Osaka, Japan) at 37ºC. The reference interval of total serum amylase activity was from 40 to 160 U/L.

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Amylase-producing multiple myeloma

Takeya

Matsuzaki

Hata

et al. 1989

Vichows Archiv A Pathol Anat

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The first autopsy case of amylase-producing IgA-lambda-type multiple myeloma is described. Immunohistochemically, amylase and alpha and lambda chains of immunoglobulin were demonstrated in the cytoplasm of the myeloma cells. Secretion of amylase by cultured myeloma cells obtained from the patient's pleural effusion was clearly demonstrated by the starch film method. Immunoelectron microscopically, positive reaction products for amylase and the alpha chain of immunoglobulin were observed in the well developed endoplasmic reticulum. Since no secretory granules were observed, we postulated that the secretory process of amylase was not via the zymogen granules but via a mechanism similar to that for immunoglobulin.

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Immunohistochemical and immunoelectron microscopic study of an amylase-producing, CA19-9 positive ovarian mucinous cystadenocarcinoma

Cited by 4 publications

References 17 publications

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

Sialyl Salivary–Type Amylase Associated with Ovarian Cancer

Amylase-producing multiple myeloma

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