Immunohistochemical and molecular subtypes of breast cancer in Nigeria

Adebamowo, Clement; Famooto, Ayo; Ogundiran, Temidayo O.; Aniagwu, Toyin; Nkwodimmah, Chibuzor; Akang, E. E. U.

doi:10.1007/s10549-007-9694-5

Cited by 118 publications

(137 citation statements)

References 25 publications

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“…The study concluded that the diferences between the Sudanese and the Italian breast cancer series relected stage at diagnosis rather than intrinsic biological characteristics [33]. This was in accordance with data reported for a breast cancer series from Nigeria, where Adebamowo and collaborators reported a high frequency of hormone receptor-positive cases, when the histopathology samples were collected under rigorous control for appropriate ixation [50]. On the contrary, studies that compared extensive series of African-American and European-American breast cancer patients found associations between aggressive estrogen receptor (ER)-negative breast cancer and both younger age at diagnosis and black ethnicity [19,40,48].…”

Section: Major Clinicopathological Features Of Breast Cancer In Sudansupporting

confidence: 86%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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Litle is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high-grade and triple-negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up-to-date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource seting. A beter understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.

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Section: Major Clinicopathological Features Of Breast Cancer In Sudansupporting

confidence: 86%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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“…(16) Early age at onset and aggressive clinical features have frequently been documented in clinical series from Africa and case series from several centers in Africa have reported that hormone receptor-negative cases are predominant (17)(18)(19), for example, only 25% of cases in a large multicenter series of patients from West Africa were ERpositive, less than half that observed in the U.S. Black (20,21). However, these findings from Africa were based on archival materials and the role of antigen degradation and false negative results could not be ruled out (18). Indeed, a more recent prospective case-series study in South African Black women found that only 35% of breast cancer cases were ER negative (22), which was comparable with those which had been reported in U.S. Black women (20,21).…”

Section: Discussionmentioning

confidence: 99%

Cancer in Africa 2012

Parkin

Bray

Ferlay

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

300

280

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Background: Noncommunicable diseases, and especially cancers, are recognized as an increasing problem for low and middle income countries. Effective control programs require adequate information on the size, nature, and evolution of the health problem that they pose.Methods: We present estimates of the incidence and mortality of cancer in Africa in 2012, derived from "GLOBOCAN 2012," published by the International Agency for Research on Cancer.Results: There were 847,000 new cancer cases (6% of the world total) and 591,000 deaths (7.2% of the world total) in the 54 countries of Africa in 2012, with about three quarters in the 47 countries of Sub-Saharan Africa. While the cancer profiles often differ markedly between regions, the most common cancers in men were prostate (16.4% of new cancers), liver (10.7%), and Kaposi sarcoma (6.7%); in women, by far the most important are cancers of the breast (27.6% of all cancers) and cervix uteri (20.4%).Conclusions: There are still deficiencies in surveillance systems, particularly in Sub-Saharan Africa and, specifically, of their most vital component, population-based cancer registries. With the number of annual cancer cases and deaths likely to increase by at least 70% by 2030, there is a pressing need for a coordinated approach to improving the extent and quality of services for cancer control in Africa, and better surveillance systems with which they can be planned and monitored.Impact: The results are the best data currently available and provide a reasonable appraisal of the cancer situation in Africa. Cancer Epidemiol Biomarkers Prev; 23(6); 953-66. Ó2014 AACR.

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“…By contrast, a study of indigenous West African women found that the proportions of luminal A, luminal B, HER2 type, basal-like, and unclassified tumors were 27%, 2%, 15%, 27%, and 28%, respectively [14]. Another study from Nigeria found that 77.6% were luminal type A, 2.6% luminal type B, 15.8% basal-like, and the remaining 4.0% HER2 type [15] A study from North Africa (Egypt) reported 44% luminal A, 26.6% luminal B, 11.8% HER2 type, 11.3% basal-like, and 7.9% unclassified [16], while a study from Sudan found a high proportion of ER-and PR-positive tumours [17] and lower basal-like (10%) phenotypes [18]. This last study did not assess the HER2 type of breast carcinoma.…”

Section: Introductionmentioning

confidence: 93%

Molecular Biology of Breast Cancer in the Horn of Africa: Case Series—A Pilot Study of Breast Cancer from Eritrea

Tesfamariam

Roy

2013

ISRN Pathology

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Background. Recently, gene expression profiling and its surrogate immunohistochemistry (IHC) markers classified breast cancer into four distinct molecular subtypes, which have different prognoses, targeted therapies, and/or clinical outcomes. Objective. To conduct a preliminary study, to correlate the clinical pathological profiles and taxonomy of molecular subtypes of breast cancer in Eritrea, in the Horn of Africa. Design. Review of pathology reports from Jan. 1 to Nov. 30, 2009, provided 22 cases of microscopically confirmed invasive breast carcinoma that were evaluable for histology and IHC (ER, PR, HER2, and Cytokeratin 5/6). Result. Twenty patients were female and most of them (68%) were under 50 years at presentation. 90% were invasive invasive carcinoma of no special type and were histological grade 3. The molecular subtypes were luminal A (55%), luminal B (5%), HER2 (5%), basal-like (10%), and unclassified (25%). Triple negative carcinoma (basal-like and unclassified combined) was 35%, mostly (71%) in women under 50 years with grade 3 tumours. Conclusion. Breast carcinoma in Eritrean women presents at a younger age and with a high histologic grade. The two predominant molecular subtypes are luminal A and triple negative. Determining the molecular subtype using surrogate IHC markers has important treatment and prognostic implications for Eritrean women with breast cancer.

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Immunohistochemical and molecular subtypes of breast cancer in Nigeria

Abstract: We conclude that there is no difference in the pattern of hormone receptors in breast cancer patients of African origin compared to other populations and urge more use of hormone manipulation for management of breast cancer in this population.

Cited by 118 publications

References 25 publications

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Cancer in Africa 2012

Molecular Biology of Breast Cancer in the Horn of Africa: Case Series—A Pilot Study of Breast Cancer from Eritrea

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