Immunohistochemical and Ultrastructural Study of Rhabdosphincter Component of the Prostatic Capsule

Elbadawi, Ahmad; Mathews, Ranjiv; Light, J. Keith

doi:10.1016/s0022-5347(01)64138-7

Cited by 56 publications

(33 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is no kind of fascia between the two areas (12,(22)(23)(24). In our sample we have found the same interdigitations between the two muscular types, even though no fascial structure has been found.…”

Section: Commentssupporting

confidence: 65%

Disposition of the striated urethral sphincter and its relation to the prostate in human fetuses

et al. 2007

View full text Add to dashboard Cite

Objective: To describe the arrangement of the muscle fibers of the striated urethral sphincter and its relationship with the prostate during the fetal period in humans. Materials and Methods:We analyzed 17 prostates from well preserved fresh human fetuses ranging in age from 10 to 31 weeks postconception (WPC). Transversal sections were obtained and stained with Gomori's trichrome and immunolabeled with anti alpha-actin antibody. Results: We found that the urethral striated sphincter (rabdosphincter) is located on the periphery of the smooth muscle and there was no merge between striated and smooth muscle fibers in any fetal period. In the prostate apex, the striated sphincter shows a circular arrangement and covers completely the urethra externally, whereas adjacent to verumontanum, it looks like a "horseshoe" and covers only the anterior and lateral surfaces of the urethra. Near the bladder neck, in fetuses younger than 20 WPC, we have found striated muscle fibers only at the anterior surface of the prostate, while in fetuses older than 20 WPC, the striated muscle covers the anterior and lateral surfaces of the prostate. Conclusions: The urethral sphincter muscle covers the anterior and lateral surfaces of the urethra in all fetuses older than 20 WPC, close to the bladder neck and at the distal prostate. In the region of the prostate apex, the urethral sphincter covers completely the urethra circularly. The knowledge of the normal anatomy of the urethral sphincter in fetuses could be important to understand its alterations in congenital anomalies involving the base of the bladder, the bladder neck and the proximal urethra.

show abstract

Section: Commentssupporting

confidence: 65%

Disposition of the striated urethral sphincter and its relation to the prostate in human fetuses

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Of interest is a report of T-type Ca 2+ channel activity in cells cultured from the rhabdosphincter of the male urethra [15]. Although this is a skeletal muscle, postulated to provide a major continence mechanism in this part of the urinary tract [16], it responds by contracting to exogenous agonists and has many features intermediate between skeletal and smooth muscle [17]. However, active tone of the muscle is important to maintain a closed bladder outlet during bladder filling, and we may hypothesise that T-channel activity contributes to the myogenic component of the maintenance of this sphincter mechanism.…”

mentioning

confidence: 99%

T-type Ca2+ channels in non-vascular smooth muscles

Fry

Sui

2006

Cell Calcium

View full text Add to dashboard Cite

“…There are interindividual variations in the shape of the apex, according to different forms of the urethral rhabdosphincter, which is the outermost of the three muscle layers that make up the urethral sphincter [18]. There is an imperceptible transition between prostate glandular tissue and the urethral sphincter muscle, because the rhabdosphincter sometimes invades the pseudocapsule of the prostate or between the glandular tissues at the apex [19]. From a clinicopathological point of view, the extent of anterior prostate cancer is underestimated by biopsy.…”

Section: Discussionmentioning

confidence: 99%

The Role of Staging MRI in Predicting Apical Margin Positivity for Robot-Assisted Laparoscopic Radical Prostatectomy

Yao

Iwamoto²,

Masago³

et al. 2014

Urol Int

View full text Add to dashboard Cite

Purpose: To investigate the association between apical margin positivity and preoperative magnetic resonance imaging (MRI) in patients who have undergone robot-assisted laparoscopic radical prostatectomy (RARP). Patients and Methods: From September 2010 through November 2012, we treated 84 Japanese men with clinically localized prostate cancer with RARP. The excised specimens, which were divided into right and left fragments, were evaluated for the presence of positive surgical margins (PSMs) and preoperative MRI findings. Results: The overall PSM rate was 21.4% (18 of 84 patients), 83.3% (15 of 18 cases) of which were situated in the apex. Evaluating the prostate divided into right and left fragments, the PSM rate was 10.7% at the apex (18 of 168 fragments). Cancer was suspected via preoperative MRI in 39 fragments (23.2%) and detected in the prostatic apex by prostate biopsy in 67 fragments (39.9%). Multiple regression analysis revealed that MRI and nerve-sparing procedures significantly indicate apical margin positivity (p = 0.005). Conclusions: The prostatic apex is the most common location of PSMs after RARP. Our results demonstrate that preoperative MRI for cancer of the prostatic apex may provide substantial information and enable complete cancer clearance.

show abstract

Immunohistochemical and Ultrastructural Study of Rhabdosphincter Component of the Prostatic Capsule

Cited by 56 publications

References 29 publications

Disposition of the striated urethral sphincter and its relation to the prostate in human fetuses

Disposition of the striated urethral sphincter and its relation to the prostate in human fetuses

T-type Ca2+ channels in non-vascular smooth muscles

The Role of Staging MRI in Predicting Apical Margin Positivity for Robot-Assisted Laparoscopic Radical Prostatectomy

Contact Info

Product

Resources

About