Immunohistochemical Characterization of a Renal Nephroblastoma in a &lt;i&gt;Trp&lt;/i&gt;53-mutant and Prolyl Isomerase 1-deficient Mouse

Castiglioni, Valentina; Maglie, Marcella De; Queliti, Roberta; Rustighi, Alessandra; Sal, Giannino Del; Radælli, Enrico

doi:10.1293/tox.2013-0021

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Instead, in this report we found in this case that the blastema cells were negative for cytokeratin and vimentin, which is in agreement with Castiglioni et al (2013), and marked positive for S100. The mesenchymal cells are marked positive for vimentin and smooth muscle actin, which is in agreement with Yamamoto et al (2006), which may demonstrate that these cells are differentiating into smooth muscle tissue (CASTIGLIONI et al, 2013).…”

Section: Introductionsupporting

confidence: 77%

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Bianchi

Konradt

Leite-Filho

et al. 2017

SCA

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Nephroblastoma is a congenital renal neoplasm composed of metanephric blastema and stromal cells. A one-year-old male Angus calf presented with diarrhea, nasal discharge, cough and weight loss. Serum levels of creatinine and urea were increased, with reduction in the level of albumin. After eight days, clinical condition got worse and the calf died. On necropsy, the cranial pole of the left kidney presented a firm whitish mass (30 x 21 x 14 cm). Multifocal to coalescing firm whitish nodules were observed on the serosa of the large intestine, in the mesentery and in the adventitia of the urinary bladder. All lung lobes contained multifocal to coalescing firm whitish elevated nodules (0.5 to 1 cm of diameter). Histologically, renal mass consisted of neoplastic proliferation of embryonal epithelial and mesenchymal cells, intermixed with large amounts of blastema cells. The nodules on large intestine, mesentery, urinary bladder and lungs were composed mainly of blastema cells and mild amount of mesenchymal cells. Blastema cells were also observed within lymphatic vessels in lung parenchyma. Embryonal epithelial, mesenchymal and blastema cells showed, respectively, positive immunostain for cytokeratin, vimentin and S100. Based on pathological and immunohistochemical findings, the tumor was diagnosed as nephroblastoma in a calf with metastasis through lymphatic vessels to lungs, large intestine, mesentery and urinary bladder. Key words: Cattle. Congenital. Neoplasm. Nephroblastoma. ResumoO nefroblastoma é uma neoplasia renal congênita composta por um blastema metanéfrico e células estromais. Um bezerro Angus, macho, de um ano de idade apresentou diarreia, descarga nasal, tosse e perda de peso. Os níveis de creatinina e ureia estavam aumentados, com albumina diminuída. Após oito dias, a condição clínica piorou e o bezerro veio a óbito. Na necropsia, o polo cranial do rim esquerdo apresentou uma massa brancacenta firme (30 x 21 x 14 cm). Nódulos brancacentos firmes multifocais a coalescentes foram visualizados na serosa do intestino grosso, mesentério e adventícia da bexiga. Nos pulmões nódulos elevados brancacentos firmes (0.5 a 1 cm de diâmetro) multifocais a coalescentes foram observados. Histologicamente, a massa no rim consistia em proliferação neoplásica de células embrionais epiteliais e mesenquimais, entremeadas a grande quantidade de células blastemais. Os nódulos no intestino grosso, mesentério, bexiga e pulmões eram compostos principalmente por células

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Section: Introductionsupporting

confidence: 77%

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Bianchi

Konradt

Leite-Filho

et al. 2017

SCA

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“…Generally, genetic variation or abnormal embryonic development of the genitourinary tract may play a part in its pathogenesis. WT is also considered a prototype of differentiation failure (Emerson et al, 2004;Grieco et al, 2006;Castiglioni et al, 2013). Nevertheless, the cell origin of WT is not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

Identification of key carcinogenic genes in Wilms’ tumor

Liu

Xiao

et al. 2021

Genes Genet. Syst.

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This study aimed to probe carcinogenic genes and pathways associated with Wilms' tumor (WT) onset and malignancy progression. After screening, three datasets acquired from the Gene Expression Omnibus database were analyzed. Differentially expressed genes (DEGs) were identified and GO functional enrichment, KEGG pathway enrichment and protein-protein interaction (PPI) were analyzed. The DEGs with top fold change values or top protein interaction scores were used to analyze overall survival based on the TARGET WT dataset. Together, 866 up-regulated genes in GDS1791, 585 up-regulated genes in GDS2010, and 277 down-regulated genes in GDS4802 were found, from which 46 key DEGs were selected for further analysis. In the PPI network, hub positions included COL5A1, COL4A1, ARPP21, SPARCL1, CD86, LY96 and PPP1R12B. The top DEGs (ARPP21, SYNPO, PRRC2B, PPP1R12B, EFCAB2 and LY96) were selected for survival analysis, and they consistently showed a significantly positive correlation with poor survival. Together, five key carcinogenic genes (SYNPO, PRRC2B, PPP1R12B, EFCAB2 and LY96) were highly associated with WT onset and patient survival. These risk genes, interaction networks and enrichments should improve our understanding of the complex molecular mechanisms in WT development and help clinical applications.

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“…Vittoria et al reported the development of nephroblastoma in a young C57BL/6 mouse with a Pin1 deletion coupled with a Trp53 abnormality. This discovery provides novel insights into the relationship between Pin1 and nephroblastoma tumor pathogenesis ( Castiglioni et al, 2013 ).…”

Section: Effects Of Pin1 On Kidney Diseasementioning

confidence: 99%

The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

Wu,

Zou,

Tan

et al. 2024

Front. Pharmacol.

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Pin1 is a member of the peptidyl-prolyl cis/trans isomerase subfamily and is widely expressed in various cell types and tissues. Alterations in Pin1 expression levels play pivotal roles in both physiological processes and multiple pathological conditions, especially in the onset and progression of kidney diseases. Herein, we present an overview of the role of Pin1 in the regulation of fibrosis, oxidative stress, and autophagy. It plays a significant role in various kidney diseases including Renal I/R injury, chronic kidney disease with secondary hyperparathyroidism, diabetic nephropathy, renal fibrosis, and renal cell carcinoma. The representative therapeutic agent Juglone has emerged as a potential treatment for inhibiting Pin1 activity and mitigating kidney disease. Understanding the role of Pin1 in kidney diseases is expected to provide new insights into innovative therapeutic interventions and strategies. Consequently, this review delves into the molecular mechanisms of Pin1 and its relevance in kidney disease, paving the way for novel therapeutic approaches.

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Immunohistochemical Characterization of a Renal Nephroblastoma in a <i>Trp</i>53-mutant and Prolyl Isomerase 1-deficient Mouse

Cited by 4 publications

References 23 publications

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Nephroblastoma with lymphatic metastasis in an Angus calf: scientific communication

Identification of key carcinogenic genes in Wilms’ tumor

The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

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