Immunohistochemical demonstration of parafollicular (C) cells in sheep thyroid and parathyroid glands.

Okada, Hiroyuki; Matsukawa, Kiyoshi; Ohgiya, Nobuyuki; Yokota, Harumasa; Taniyama, Hiroyuki; Yuasa, Akira

doi:10.1292/jvms1939.52.879

Cited by 10 publications

(13 citation statements)

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“…C-cell concentration in the thyroid lobes of pig in deep and superficial regions is 4.9 and 2.6%, respectively (Tsuchiya et al, 1985). Although the sheep has a parathyroid IV in the thyroid lobes (Okada et al, 1990), C-cells are dispersed throughout the thyroid lobes. Although the sheep has a parathyroid IV in the thyroid lobes (Okada et al, 1990), C-cells are dispersed throughout the thyroid lobes.…”

Section: Resultsmentioning

confidence: 99%

“…humans (Wolfe et al, 1973(Wolfe et al, , 1975McMillan et al, 1974), monkeys (Kameda, 1983), rats (Blahser, 1978;de Lellis et al, 1979;Monsour et al, 1985;Zabel et al, 1987Zabel et al, ,1988Martin-Lacave et al, 1992), mice (Treilhou-Lahille et al, 1979;Wechbanjong et al, 1979;Zabel et al, 1988), guinea pigs, hamsters (Zabel et al, 1988), rabbits (Kameda, 1981;Zabel et al, 1988), dogs, (Kameda, 1981;Patnaik and Lieberman, 1991), cats, goats (Kameda, 1981), horses (Blahser, 1978;Moritomo et al, 1985;Tanimura et al, 1986), pigs (Blahser, 1978;Tsuchiya et al. C-cells are distributed in the lateral lobes of the thyroid gland and are also present in the internal parathyroid gland (parathyroid IV) of monkeys (Kameda, 1983), dogs, cats, rabbits, goats (Kameda, 1971(Kameda, , 1981 horses Tanimura et al, 1986) and sheep (Okada et al, 1990). C-cells are distributed in the lateral lobes of the thyroid gland and are also present in the internal parathyroid gland (parathyroid IV) of monkeys (Kameda, 1983), dogs, cats, rabbits, goats (Kameda, 1971(Kameda, , 1981 horses Tanimura et al, 1986) and sheep (Okada et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Ccells are generally concentrated in the central region of the lateral lobes, and few or no C-cells are distributed in the periphery of the thyroid lobes in humans (Wolfe et al,. However, C-cells are distributed throughout the thyroid lobes in dogs, cats (Kameda, 1971(Kameda, , 1981, adult rats (Monsour et al, 1985;Martin-Lacave et al, 1992), pigs (Tsuchiya et al, 1984), horses and sheep (Okada et al, 1990). , 1975McMillan et al, 1974), monkeys (Kameda, 1983), mice (Kameda, 1971;Treilhou-Lahille et al, 1979;Wechbanjong et al, 1979), neonatal rats (Monsour et al, 1985) and rabbits (Kameda, 1971(Kameda, , 1981.…”

Section: Introductionmentioning

confidence: 99%

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C‐cell Distribution in Ovine Thyroid Gland

Okada

Shigeta

Un-No

1995

Anat Histol Embryol

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The number and percentage of C-cells per unit area were investigated in 2-3-year-old sheep by an immunoperoxidase technique, using a digital-image analysis. C-cells were distributed throughout the thyroid lobes but were not present in either the isthmus or the superior and inferior poles of the thyroid. C-cells were more concentrated in the deep central region of the lobes and decreased gradually toward the periphery. There was a high correlation between the number and the percentage of C-cells per unit area of thyroid gland in sheep. Significant differences were not present between male and female sheep of 2-3 years of age.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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C‐cell Distribution in Ovine Thyroid Gland

Okada

Shigeta

Un-No

1995

Anat Histol Embryol

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“…According to Okada et al, (1990) in the sheep thyroid glands, the parafollicular cells (C cells) were oval to polyhedral in shape, frequently possessed long cytoplasmic protrusions and were located mainly in the intrafollicular and often in the parafollicular area, but were never found touching the follicular lumen. Intrafollicular C cells were mostly scattered as single elements and often formed chains.…”

Section: Parafollicular Cellsmentioning

confidence: 99%

“…Two types of follicles namely dark and light follicles were observed. Okada et al, (1990) reported that in sheep, the external parathyroid glands were devoid of C cells ln the internal parathyroids, the C cells were distributed in the periphery and frequently gathered as a large cluster in the central region and were polyhedral or elongate in shape. Roy et al, (1984) stated that in the internal parathyroid glands of the goat, light and dark chief cells were the main components of the parenchyma.…”

Section: Histomorphologymentioning

confidence: 99%

Histomorphology and Histochemistry of the Thyroid and Parathyroid Glands in Sheep - An Overview

Rajalakshmi¹,

Ramesh²,

Kumārī³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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A study on the histomorphology and histochemistry of the thyroid and parathyroid glands in sheep was conducted in the prenatal and post natal age groups of sheep. The capsule of the thyroid gland consisted of two layers of connective tissue separated by a layer of adipose tissue. The stroma showed the presence of solitary ganglion cells. The parenchyma of the thyroid gland consisted of solid epithelial cords separated by mesenchymal tissue. In sheep embroys at 25 days of gestation, precursors of C cells called dark cells were found in the ultimobranchial bodies. Multiple ciliated follicular cells were observed in the developing thyroid of dogs and were prominent at three weeks prior to the expected date of birth. The thyroid follicles were irregular in outline and the diameter increased in the older subjects. In buffaloes, the larger follicles were present in the deeper zone of the thyroid gland. The follicles were lined by follicular cells and light cells. The solid form of colloid was observed in oldest goats. In the sheep thyroid glands, the parafollicular cells (C cells) were oval to polyhedral in shape, frequently possessed long cytoplasmic protrusions and were located mainly in the intrafollicular and often in the parafollicular area. The ultimobranchial follicles of the sheep thyroid were of various shapes, sizes and forms. The ultimobranchial follicles of the sheep thyroid glands were positive for neutral and acid mucopolysaccharides, lipids and acid phosphatase activity. In the golden hamster, the parathyroid was derived from the third pharyngeal pouch, situated on day 13 of gestation on the dorsolateral side of the thyroid, being surrounded by a common capsule with the thyroid. In the parathyroids of the Wister rats, the chief cell clusters were clearly demarcated from the thyroid by a prominent connective tissue capsule with poor vascularity and the cell clusters were separated by an indistinct stroma of connective tissue with occasional fibrocytes. In the sheep parathyroids, the follicles were irregularly distributed in the gland parenchyma and consisted of chief cells, but not of water-clear cells and oxyphil cells. Two types of follicles namely dark and light follicles were observed. In goat, the secretory granules of the chief cells of the internal parathyroids were PAS positive. Chief cells in the parathyroids of duck showed acid and alkaline phosphatase activities.

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Thyroid hormones states and brain development interactions

Ahmed

El-Gareib

El-Bakry

et al. 2007

Intl J of Devlp Neuroscience

279

254

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The action of thyroid hormones (THs) in the brain is strictly regulated, since these hormones play a crucial role in the development and physiological functioning of the central nervous system (CNS). Disorders of the thyroid gland are among the most common endocrine maladies. Therefore, the objective of this study was to identify in broad terms the interactions between thyroid hormone states or actions and brain development. THs regulate the neuronal cytoarchitecture, neuronal growth and synaptogenesis, and their receptors are widely distributed in the CNS. Any deficiency or increase of them (hypo- or hyperthyroidism) during these periods may result in an irreversible impairment, morphological and cytoarchitecture abnormalities, disorganization, maldevelopment and physical retardation. This includes abnormal neuronal proliferation, migration, decreased dendritic densities and dendritic arborizations. This drastic effect may be responsible for the loss of neurons vital functions and may lead, in turn, to the biochemical dysfunctions. This could explain the physiological and behavioral changes observed in the animals or human during thyroid dysfunction. It can be hypothesized that the sensitive to the thyroid hormones is not only remarked in the neonatal period but also prior to birth, and THs change during the development may lead to the brain damage if not corrected shortly after the birth. Thus, the hypothesis that neurodevelopmental abnormalities might be related to the thyroid hormones is plausible. Taken together, the alterations of neurotransmitters and disturbance in the GABA, adenosine and pro/antioxidant systems in CNS due to the thyroid dysfunction may retard the neurogenesis and CNS growth and the reverse is true. In general, THs disorder during early life may lead to distortions rather than synchronized shifts in the relative development of several central transmitter systems that leads to a multitude of irreversible morphological and biochemical abnormalities (pathophysiology). Thus, further studies need to be done to emphasize this concept.

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Immunohistochemical demonstration of parafollicular (C) cells in sheep thyroid and parathyroid glands.

Cited by 10 publications

References 0 publications

C‐cell Distribution in Ovine Thyroid Gland

C‐cell Distribution in Ovine Thyroid Gland

Histomorphology and Histochemistry of the Thyroid and Parathyroid Glands in Sheep - An Overview

Thyroid hormones states and brain development interactions

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