Immunohistochemical demonstration of spread of Aujeszky's disease virus to the porcine central nervous system after intestinal inoculation

Narita, Minoru; Kimura, Kumiko; Tanimura, Nobuhiko; Arai, Shozo; Uchimura, A.

doi:10.1016/s0021-9975(07)80008-9

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…In an experiment in which ADV was injected into the duodenal lumen of piglets, necrotizing enteritis and myoenteritis developed several weeks later. Intestinal pathological and immunohistochemical analyses supported that ADV invaded the myenteric plexus from the intestinal lumen and spread through the solar plexus and ganglion [ 38 ].…”

Section: Viral Infection-induced Damage To Neural Pathwaysmentioning

confidence: 99%

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases

Li,

Chen,

Wang

et al. 2023

Virol J

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Gastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of gastrointestinal muscle contraction. Gastrointestinal motility maintains the normal digestive function of the human body and is a critical component of the physiological function of the digestive tract. At present, gastrointestinal motility disorder-related diseases are gradually affecting human production and life. In recent years, it has been consistently reported that the enteric nervous system has a coordinating and controlling role in gastrointestinal motility. Motility disorders are closely related to functional or anatomical changes in the gastrointestinal nervous system. At the same time, some viral infections, such as herpes simplex virus and varicella-zoster virus infections, can cause damage to the gastrointestinal nervous system. Therefore, this paper describes the mechanisms of viral infection in the gastrointestinal nervous system and the associated clinical manifestations. Studies have indicated that the means by which viruses can cause the infection of the enteric nervous system are various, including retrograde transport, hematogenous transmission and centrifugal transmission from the central nervous system. When viruses infect the enteric nervous system, they can cause clinical symptoms, such as abdominal pain, abdominal distension, early satiation, belching, diarrhea, and constipation, by recruiting macrophages, lymphocytes and neutrophils and regulating intestinal microbes. The findings of several case‒control studies suggest that viruses are the cause of some gastrointestinal motility disorders. It is concluded that one of the causes of gastrointestinal motility disorders is viral infection of the enteric nervous system. In such disorders, the relationships between viruses and nerves remain to be studied more deeply. Further studies are necessary to evaluate whether prophylactic antiviral therapy is feasible in gastrointestinal motility disorders.

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Section: Viral Infection-induced Damage To Neural Pathwaysmentioning

confidence: 99%

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases

Li,

Chen,

Wang

et al. 2023

Virol J

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“…Nerve fibers within PP have been hypothesized to modulate intestinal immune function (Pascual et al, 1994) and the cellular uptake of pathogenic bacteria (Green et al, 2003). Enteric nerves also constitute a route for infection of the central nervous system by ingested neurotrophic viruses (Morrison et al, 1991;Narita et al, 1998) and prions (van Keulen et al, 2002). The innervation of PP includes peptidergic fibers, which contain neuropeptides such as vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP).…”

Section: Introductionmentioning

confidence: 99%

Anatomical evidence for enteric neuroimmune interactions in Peyer’s patches

Vulchanova

Casey

Crabb

et al. 2007

Journal of Neuroimmunology

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Peyer's patches (PP), a key component of the gut-associated lymphoid tissue, serve as the primary inductive sites for intestinal immunity. In the present study, we addressed the hypothesis that the morphological features of PP innervation are consistent with an immunomodulatory role for the enteric nervous system. Laser scanning confocal microscopy was used to collect images through large tissue volumes, yielding a three-dimensional perspective of the neuronal network superimposed on PP follicles from porcine jejunum and human ileum. Peptidergic nerve fibers were found in close apposition to immunocytes within PP subepithelial domes and the adjacent villi. The results suggest that nerve fibers in PP may participate in neuroimmune cross-talk within individual antigen-sampling sites as well as integrate information across multiple antigen-sampling sites.

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Digestive System

Thomson¹,

Friendship²

2019

Diseases of Swine

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Immunohistochemical demonstration of spread of Aujeszky's disease virus to the porcine central nervous system after intestinal inoculation

Cited by 7 publications

References 17 publications

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases

The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases

Anatomical evidence for enteric neuroimmune interactions in Peyer’s patches

Digestive System

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