Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

Tsou, Kang; Brown, Sean M.; Sañudo-Peña, M.Clara; Mackie, Ken; Walker, J. Michael

doi:10.1016/s0306-4522(97)00436-3

Cited by 1,459 publications

(1,228 citation statements)

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“…However, several of these studies have led to ambiguous and equivocal results, which may be due to the fact that tasks evaluating higher cognitive processes probe the integrity of distributed neocortical networks (ie neocortical areas contain relatively moderate CB1 densities compared with structures such as the basal ganglia and the cerebellum). Tasks which examine cerebellar function should be particularly useful indices of the effects of exogenous cannabinoids, as the cerebellum contains the highest density of CB1 receptors in the brain (Herkenham et al, 1990;Pertwee, 1997;Tsou et al, 1998). In addition to its role in motor coordination, the cerebellum is thought to play a key role in temporal operations such as rhythm production, time estimation, and some forms of associative learning (Ivry and Keele, 1989;Katz and Steinmetz, 2002;Leiner et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Cannabis Use Disrupts Eyeblink Conditioning: Evidence for Cannabinoid Modulation of Cerebellar-Dependent Learning

Skosnik

Edwards

O’Donnell

et al. 2007

Neuropsychopharmacol

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While the cerebellum contains the highest density of cannabinoid receptor (CB1) in the brain, no studies have assessed the effect of exogenous cannabinoids on cerebellar-dependent learning in humans. The current study, therefore, examined the effect of chronic cannabis use on classical eyeblink conditioning (EBC), a cerebellar-mediated task which has been shown to be disrupted in CB1 knockout mice. Chronic cannabis users (24 h abstinence before study; positive THC urine drug test) free of DSM-IV Axis-I or -II disorders, were evaluated. A delay EBC task was utilized, in which a conditioned stimulus (CS; 400 ms tone) co-terminated with a corneal air puff unconditioned stimulus (US; 50 ms), thus eliciting a conditioned blink response (CR). The cannabis group exhibited markedly fewer, and more poorly timed CRs as compared to drug-naive controls. There were no differences between the groups in either the unconditioned response (UR) or an EEG measure of selective attention to the CS (N100 auditory ERP), indicating that the disruption observed in the cannabis group was specific to CR acquisition. These results suggest that cannabis use is associated with functional deficits in the cerebellar circuitry underlying EBC, a finding which corroborates the recent work in CB1 knockout mice.

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Section: Introductionmentioning

confidence: 99%

Cannabis Use Disrupts Eyeblink Conditioning: Evidence for Cannabinoid Modulation of Cerebellar-Dependent Learning

Skosnik

Edwards

O’Donnell

et al. 2007

Neuropsychopharmacol

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“…CB1Rs are very strongly expressed in Purkinje cell pinceaux (Tsuo et al, 1998). This suggests that the possibility by CB1Rs 14 M.A.…”

Section: Functional Implications Of Dsi In the Cerebellummentioning

confidence: 97%

Endocannabinoid‐mediated short‐term synaptic plasticity: depolarization‐induced suppression of inhibition (DSI) and depolarization‐induced suppression of excitation (DSE)

Diana

Marty

2004

British J Pharmacology

238

177

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Depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE) are two related forms of short-term synaptic plasticity of GABAergic and glutamatergic transmission, respectively. They are induced by calcium concentration increases in postsynaptic cells and are mediated by the release of a retrograde messenger, which reversibly inhibits afferent synapses via presynaptic mechanisms. We review here:(1) The evidence accumulated during the 1990s that has led to the conclusion that DSI/DSE rely on retrograde signaling. (2) The more recent research that has led to the identification of endocannabinoids as the retrograde messengers responsible for DSI/DSE. (3) The possible mechanisms by which presynaptic type 1 cannabinoid receptors reduce synaptic efficacy during DSI/DSE. (4) The possible modes of induction of DSI/DSE by physiological activity patterns, and the partially conflicting evaluations of the calcium concentration increases required for cannabinoid synthesis. (5) Finally, the relation between DSI/DSE and other forms of long-and short-term synaptic inhibition, which were more recently associated with the production of endocannabinoids by postsynaptic cells.We conclude that recent studies on DSI/DSE have uncovered a specific and original mode of action for endocannabinoids in the brain, and that they have opened new avenues to understand the role of retrograde signaling in central synapses.

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“…Similarly, nicotine administration also modifies locomotion, anxiety, memory, nociception, and produces rewarding effects in several animal models (Clarke and Kumar, 1983;Hildebrand et al, 1999;Marubio et al, 1999;Picciotto et al, 1995). Neuroanatomical studies have shown a high density of CB1 receptors in neurons of the cerebellum, basal ganglia, limbic cortices, hippocampus, 3 hypothalamus and different nuclei of the extended amygdala (Tsou et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

2006

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Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: The present study was designed to examine the possible involvement of the cannabinoid system in the anxiolytic-and anxiogenic-like responses induced by nicotine in mice. Methods:

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Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

Cited by 1,459 publications

References 50 publications

Cannabis Use Disrupts Eyeblink Conditioning: Evidence for Cannabinoid Modulation of Cerebellar-Dependent Learning

Cannabis Use Disrupts Eyeblink Conditioning: Evidence for Cannabinoid Modulation of Cerebellar-Dependent Learning

Endocannabinoid‐mediated short‐term synaptic plasticity: depolarization‐induced suppression of inhibition (DSI) and depolarization‐induced suppression of excitation (DSE)

Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

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