Immunohistochemical evaluation of VEGF and tryptase for angiogenesis and mast cell counting in giant cell granulomas of the jaws

Saghravanian, Nasrollah; Mohtasham, Nooshin; Vahedi, Mahdi; Ghazi, Narges; Aghaee, Monavar Afzal

doi:10.1016/j.ajoms.2017.12.002

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Twenty studies were mainly associated with pathogenesis and nature of GCLs of jaws [ Table 2 ]. [ 2 3 11 13 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 ] Studies suggested p63 and OCT-4 as the markers that could differentiate between GCT of long bones and GCLs of jaws.…”

Section: Resultsmentioning

confidence: 99%

Unravelling the role of immunohistochemistry in giant cell lesions of jaws

Gupta¹,

Sharma

Hooda³

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Controversies exist in literature regarding nature, pathogenesis, and behaviour of giant cell lesions (GCLs) of jaws. Studies were attempted to solve these mysteries with immunohistochemical analysis, using various biological markers. Thus, the aim of this review is to appraise the role of immunohistochemistry (IHC) in evaluating the pathogenesis, cellular phenotype, nature, and behaviour of GCLs of jaws. PubMed, PubMed Central, and Clinical Key (Medline) databases were searched electronically irrespective of date of publication with assortment of several independent terms. Fifty-five articles that fulfilled the eligibility criteria were included in the review. Out of 55 included articles, 49 were associated with nature, pathogenesis, and behaviour and six articles were associated with treatment and outcome prediction. Although IHC solved some of the controversies associated with GCLs of jaws such as the osteoclastic phenotype of multinucleated giant cells, immunoexpression of proliferative markers does not distinct non-aggressive from aggressive central GCL but the nature, histogenesis, pathogenesis, and exact behaviour still remain debatable. With regard to formulation of treatment plan, immunohistochemical analysis revealed that expression of glucocorticoid and calcitonin receptors could act as a tool to decide the therapeutic strategy and aid in therapeutic adjustments according to evolution of the lesion.

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Section: Resultsmentioning

confidence: 99%

Unravelling the role of immunohistochemistry in giant cell lesions of jaws

Gupta¹,

Sharma

Hooda³

et al. 2023

Journal of Oral and Maxillofacial Pathology

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“…Higher overall expression of VEGF in CGCG might lead to increased vascularity as well as more destructive nature. VEGF is involved in tumor growth via the mechanism of neoangiogenesis to meet the oxygen and nutrient requirement of tumor cells and is involved in pathogenesis [17].…”

Section: Discussionmentioning

confidence: 99%

Central Giant Cell Granuloma of the Mandible: A Case Report

Tamba¹,

Kane²,

Diatta³

et al. 2020

IJCOMS

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The central giant cell granuloma (CGCG) of the jaws is a rare benign tumour of the mandible (lower jaw) and the maxilla (upper jaw) characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. It is asymptomatic and present with slow growth often accompanied by dental mobility. The removal of this tumour is mutilating and is followed prosthetic rehabilitation. The aim of this study was to report a case of central giant cell granuloma localizated to the symphyseal region in a young patient. The case reported is that of a 14-year-old girl who received a consultation for a tumor in the symphysical region causing an aesthetic impact. The tumor was firm, painless and had been developing for about a year. The cortical were broken in places, in transverse, sagittal and coronal sections. The treatment consisted of her excision under general anesthesia causing a significant loss of substance. The tumor mass, very hemorrhagic, was extended to the buccal floor. At the end of the intervention, a significant loss of substance was observed. Two months later, a partial adjunct prosthesis was performed. The anatomo-pathological examination showed of several multinucleated giant cells, a few histiocytes, lymphocytes and fibroblasts. The removal of this aggressive tumour remains mutilating, with significant psychological repercussions. More recently, antiangiogenic therapy with interferon alpha has been successfully applied.

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Immunohistochemical evaluation of VEGF and tryptase for angiogenesis and mast cell counting in giant cell granulomas of the jaws

Cited by 2 publications

References 21 publications

Unravelling the role of immunohistochemistry in giant cell lesions of jaws

Unravelling the role of immunohistochemistry in giant cell lesions of jaws

Central Giant Cell Granuloma of the Mandible: A Case Report

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