Immunohistochemical expression of alpha‐smooth muscle actin and glucocorticoid and calcitonin receptors in central giant‐cell lesions

Maiz, Nancy Noya; Rosa-García, Estela de la; Camacho, María Esther Irigoyen

doi:10.1111/jop.12377

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…This result is in agreement with the previous studies. [ 17 ] Thus, myofibroblasts are important components of stromal cells in central giant cell lesions and alpha-smooth muscle actin immunoexpression was associated with features of local aggressiveness such as root resorption and cortical bone involvement. [ 15 18 ] Moreover, the pattern of distribution of these mononuclear myofibroblastic cells around the abnormal vessel spaces suggested that these cells might play a role in generating newly formed blood vessels and spaces.…”

Section: Discussionmentioning

confidence: 99%

Correlation of density of microvessels and myofibroblasts with the aggressiveness of central giant cell granulomas of jaws

Soni

Phulari

Shah

2022

Journal of Oral and Maxillofacial Pathology

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Objectives: Central giant cell granuloma (CGCG) is a fairly common lesion involving the jaw bones. CGCG can show relatively innocuous biological behaviour or it may show clinicoradiological features suggestive of aggressive biological behaviour. To date, there are no histological parameters which can be used to predict the behaviour of these lesions. This study was conducted to assess the utility of parameters of angiogenesis, i.e., total vascular area (TVA), mean vascular area (MVA) and microvessel density (MVD), and density of myofibroblasts in aggressive and non-aggressive CGCGs. Materials and Methods: The study was undertaken as a retrospective study. A total of 20 previously diagnosed cases (10 non-aggressive and 10 aggressive) of CGCGs were included in the study. The sections were subjected to immunohistochemistry using the markers CD34 and α-SMA. For the assessment of vascular parameters, image J software was used. The density of myofibroblasts was determined in each case ranging from score-1 to 4, using the criteria given by Sridhara et al. The correlation between mean values of vascular parameters and density of myofibroblasts with aggressiveness of CGCG was assessed using Mann–Whitney U test. Results: The result of Mann–Whitney U test suggested that the differences between the values of TVA (P < 0.001), MVA (P < 0.003) and density of myofibroblasts, i.e., SMA mean (P < 0.001) and SMA score (P < 0.001), in two groups are statistically significant. The formula for the assessment of aggressiveness was obtained using discriminant analysis. Conclusions: Angiogenesis and density of myofibroblasts significantly differ in aggressive and non-aggressive cases of CGCGs. The aggressiveness of CGCG case can be predicted using the obtained formula by entering the values of vascular parameters and myofibroblasts.

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Section: Discussionmentioning

confidence: 99%

Correlation of density of microvessels and myofibroblasts with the aggressiveness of central giant cell granulomas of jaws

Soni

Phulari

Shah

2022

Journal of Oral and Maxillofacial Pathology

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Regarding “Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities: A Case Report”

Alerraqi¹

2016

Journal of Oral and Maxillofacial Surgery

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Immunoexpression of calcitonin and glucocorticoid receptors in central giant cell lesions of the jaws

Severo

Lopes

Miguel

et al. 2018

J Oral Pathology Medicine

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Immunohistochemical expression of alpha‐smooth muscle actin and glucocorticoid and calcitonin receptors in central giant‐cell lesions

Abstract: Myofibroblasts are important components of CGCLs, stromal cells and alpha-smooth muscle. Actin immunoexpression was associated with root and cortical bone resorption.

Cited by 4 publications

References 30 publications

Correlation of density of microvessels and myofibroblasts with the aggressiveness of central giant cell granulomas of jaws

Correlation of density of microvessels and myofibroblasts with the aggressiveness of central giant cell granulomas of jaws

Regarding “Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities: A Case Report”

Immunoexpression of calcitonin and glucocorticoid receptors in central giant cell lesions of the jaws

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