Immunohistochemical expression of c‐erbB‐2 oncoprotein and EGF‐R in pre‐ and postmenopausal breast cancer

Ratnakar, Nitesh; Sharma, B. K.; Chaturvedi, K. Uma; Kaur, Simran; Naik, S. L. D.; Ray, Arunima

doi:10.1111/j.1699-0463.1998.tb00261.x

Cited by 3 publications

(2 citation statements)

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“…Lipponen et al (21) found that 31% of patients of 10mast cancer were positive for c-erbB-2. The finclngs on immunoexpr _~__r of EGF-R and c-erbB-2 of this study are in confirmation with the report of Ratnakar et al (15). In addition, our study noticed a correlation of border line significance between the immunopositivity of EGF-R and lymph node involvement; however, no such relationship could be established with c-erbB-2 p(otein.…”

Section: Discussionsupporting

confidence: 92%

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Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Jain

Bahadur

et al. 2001

Indian J Clin Biochem

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There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 48 cases of these two hormone-dependent cancers along with approprlats controls were subjected for status of epidermal growth factor receptors as well as serum lipid profile. Paraffin embedded tissue sections from afonmald tumum were analysed by immunohistochemical stuining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotsin, nslxogen mcapt~ (ER) and Wogestmmne receptor (PgR). Sere from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglyc~Ntdas, total cholesterol, LDL-cholestsrol were found to be significantly elevated while the level of HDL-cholesterol was observed to be lower among patients with breast cancer as compared to matched oonlxols. Further, ER-posilive breast cancar cases have significant~ higher mean level of HDL-cholasterol when compared with ER-negative breast cancer patients. Contrary to this, no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer.KEY WORDS : EGF-R, c-err6-2, lipids, breast cancer and prostate cancer.

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Section: Discussionsupporting

confidence: 92%

“…Immunohistochernical staining was performed as described by Ratnakar et al (15). The murine monocional antibodies directed against the extracellular domain of EGF-R (Sigma, USA) and cerbB-2 protein (Boehringer Mannheim, Gen~any) as well as ER (ER-D5 antigen, ~m, UK) and PgR (Sigma, USA) were used as primary antibodies.…”

Section: Methodsmentioning

confidence: 99%

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Jain

Bahadur

et al. 2001

Indian J Clin Biochem

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Significación clínica del contenido tumoral del receptor del factor de crecimiento epidérmico en el cáncer de mama

Mulero¹,

Raigoso²,

Vázquez

et al. 2003

Revista Española de Medicina Nuclear

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Immunohistochemical detection of EGFR, p185^erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women

Talley

Chhieng

Bell

et al. 2008

Biotechnic & Histochemistry

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Young pre-menopausal women with breast carcinomas have an overall worse prognosis than older, post-menopausal women. Because histologic grade is a major predictor of tumor behavior and correlates with biomarker expression, we assessed the immunohistochemical expression of epidermal growth factor receptor (EGFR), p185(erbB-2) and Bcl-2, and nuclear accumulation of p53 in breast carcinomas in pre- and post-menopausal women with equivalent histologic grades. This allowed identification of differences in biomarker expression and prognostic significance in pre- and post-menopausal women independent of histologic grade. We investigated 100 infiltrating ductal carcinomas (IDC) in pre-menopausal women, ages 45 years and younger, and 100 IDC in post-menopausal women, ages 65 years and older. The IDC were selected so that the proportions of high and low/moderate grade carcinomas were equal in the pre- and post-menopausal groups. Prognostic utility of biomarker expression in pre- and post-menopausal groups was determined by product limit and multivariate analysis of survival. There were statistically significant differences in cytoplasmic expression of EGFR and Bcl-2 and nuclear accumulation of p53, but not in the expression of p185(erbB-2), in carcinomas of high vs. low histologic grade. There was no difference in the expression of EGFR, p185(erbB-2) or Bcl-2, or in nuclear accumulation of p53 in these IDC from pre- vs. post-menopausal women. Bcl-2 and the nuclear accumulation of p53 were of prognostic significance in our overall study population; however, when assessing pre- and post-menopausal women separately, Bcl-2 and p53 were of prognostic significance only in pre-menopausal, but not post-menopausal women. In summary expression of EGFR and Bcl-2 and nuclear accumulation of p53 were significantly associated with histologic grade, but not with menopausal status. In addition, there were differences in the prognostic effectiveness of these biomarkers in pre- vs. post-menopausal women.

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Immunohistochemical expression of c‐erbB‐2 oncoprotein and EGF‐R in pre‐ and postmenopausal breast cancer

Cited by 3 publications

References 20 publications

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Significación clínica del contenido tumoral del receptor del factor de crecimiento epidérmico en el cáncer de mama

Immunohistochemical detection of EGFR, p185^erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women

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Immunohistochemical expression of c‐erbB‐2 oncoprotein and EGF‐R in pre‐ and postmenopausal breast cancer

Cited by 3 publications

References 20 publications

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Significación clínica del contenido tumoral del receptor del factor de crecimiento epidérmico en el cáncer de mama

Immunohistochemical detection of EGFR, p185erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women

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Immunohistochemical detection of EGFR, p185^erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women