Immunohistochemical expression of matrix metalloproteinases in photodamaged skin by photodynamic therapy

Abstract

Skin remodelling induced by MAL-PDT was demonstrated in photodamaged skin. Two sessions of MAL-PDT increases immunohistochemical expression of MMP-9 in the dermis at 3 months after treatment, and also of collagen type I.

Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast

“…The proliferation of osteoblasts26 and alveolar bone cells27 treated with 1~5% PRP was higher than that of cells treated with higher concentrations of PRP. Similarly, it was shown that maximal stimulation of HDF proliferation was achieved using 5% aPRP29. Our study indicates that aPRP stimulates the proliferation of HDF, consistent with the findings described above.…”

“…This stimulation of de novo collagen synthesis may compensate for the defects that arise due to the fragmentation or loss of collagen in photoaged and aged skin. Accumulation of this newly-synthesized collagen may improve the structural integrity of the dermal ECM and stimulate fibroblasts to produce more collagen29.…”

“…MMPs digesting various structural components of the ECM are centrally involved in dermal remodelling30. Similar induction of MMP-1 in photoaged skin may facilitate the removal of collagen fragments that damage the dermal matrix tissue, thus providing a better foundation for the deposition of new collagen29.…”

Topical 5-Aminolevulinic Acid with Intense Pulsed Light versus Intense Pulsed Light for Photodamage in Chinese Patients

“…Higher success rates for fine lines and coarse wrinkles at the final visit on the ALA‐IPL PDT side were also found. Improvement in fine lines and wrinkles on the ALA‐IPL PDT side was seen even after the treatment was finished, as has been reported previously 10 . This, as suggested in our case, was due to subjects not strictly avoiding the sun, in which cases, sunlight served as a huge low‐dose activator of the remaining PpIX.…”

Aesthetic effects of topical photodynamic therapy

“…The accumulation of partially degraded and fragmented collagen, such as it is present in photoaged skin, inhibits neocollagenesis 22 . Proteolytic clearance of fragmented collagen by MMPs plays therefore a decisive role in restoring collagen biosynthesis, 23,24 whereas induction of MMPs by non‐ablative laser energy and PDT is quantitatively more modest than with CO 2 ‐laser 14,22,25,26 …”