Immunohistochemical identification of lysozyme in intestinal lesions in ulcerative colitis and Crohn's disease.

Serum and faecal lysozyme in inflammatory bowel disease.

“…On the other hand, cells of the granulocyte and monocyte series are also present in the intestinal mucosa of patients with inflammatory bowel disease, particularly those with ulcerative colitis (Anthonisen e Non IBD gastrointestnal disease with diarrhoea and Riis, 1962;Levine and Engle, 1969;Riis and Anthonisen, 1971). They contain lysozyme (Klockars et al, 1977) and probably contribute to the lysozyme content of the mucosa by releasing the enzyme as they degranulate (Fink and Finch, 1968). Paneth cells also contain and can secrete lysozyme ; the Paneth cell population is increased in Crohn's disease (Lewin, 1969), and Paneth cell metaplasia is a common finding in ulcerative colitis.…”

“…Paneth cells also contain and can secrete lysozyme ; the Paneth cell population is increased in Crohn's disease (Lewin, 1969), and Paneth cell metaplasia is a common finding in ulcerative colitis. Colonic mucosal crypt cells in ulcerative colitis have also been shown to contain lysozyme (Klockars et al, 1977). It is possible that lysozyme from these various sources is secreted or diffuses into the systemic circulation and into the bowel lumen.…”

Paneth cells: their role in innate immunity and inflammatory disease

“…26 Immunohistochemical studies indicate that they express the antimicrobial proteins lysozyme, 61 sPLA2, 62 and a-defensins. 26 It is likely that in the colon affected by inflammatory bowel disease, metaplastic Paneth cells help protect the damaged colonic epithelium against bacterial invasion.…”

How are the expression patterns of gut antimicrobial peptides modulated by human gastrointestinal diseases? A bridge between infectious, inflammatory, and malignant diseases

“…Bacteria are displayed as present in the nonsterile mucus layer only, and different colours represent different bacterial "niches", meaning that each "nich"/colour reflects a different bacteria predominance. Created using Servier Medical Art Crohn's disease (adulthood and childhood) ↓ Human defensin-5 (Ileal) 34 ↓ Human defensin-6 (Ileal) 34 ↑ Human defensin-6 35 (Paneth cell metaplasia) 36 ↑ Human beta-defensin-2 37 ↓ Bactericidal/permeability-increasing protein 23 ↑ Human defensin-5 (Paneth cell metaplasia) 14 35 17…”