Serum and faecal lysozyme in inflammatory bowel disease.

Klass, H J; Neale, G.

doi:10.1136/gut.19.3.233

Cited by 41 publications

(23 citation statements)

References 26 publications

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“…It is known that an increase in serum lysozyme levels is often associated with inflammatory processes of the intestinal apparatus (Nugent et al, 1976;Klass and Neale, 1978). This hypothesis was confirmed in a recent study (Mugnai et al, 2008) in which weaned young rabbits reared in extensive housing conditions showed a decreasing trend of serum lysozyme with age -with the post-weaning phase being the most critical period for morbidity and mortality (Padilha et al, 1995;Maertens and Štruklec, 2006).…”

Section: Resultssupporting

confidence: 69%

Native immunity and oxidative traits of growing rabbits

Moscati¹,

Bosco²,

Battistacci³

et al. 2010

World rabbit sci.

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AbstrAct:The evaluation of animal welfare through innate immunity (Serum Bactericidal Activity -SBA, Hemolytic Complement Assay -HCA, lysozyme) and the antioxidant status of the body (Reactive Oxygen Substances -ROS and Antioxidant Power of plasma, AP) offers a reliable prognostic and diagnostic tool. The aim of the present study was to investigate trends and correlations between some traits of innate immunity and the oxidative status of fattening rabbits at different ages. Blood samples from 120 New Zealand White fattening rabbits at 45, 55, 65, and 75 d of age were collected and analyzed. The results showed that SBA did not have a normal distribution because of numerous 0 values. Data distribution was normal when only SBA > 0 values were considered. Lysozyme (mean value 27.19 μg/mL) and HCA (mean value 50.84 CH 50% ) had stable trends at different ages and showed a tendency that was comparable to that obtained in other animal species. On the contrary, SBA (mean value 42.15%) showed an unexpected positive correlation with lysozyme (P<0.001) and a negative correlation with HCA (P<0.001). Oxygen free-radicals are involved in the pathogenesis of several diseases and oxidative stress alters immune competence. In this experiment, ROS and AP showed mean values of 0.60 mmol H 2 O 2 and 421.67 μmol HClO, respectively. In this context positive correlation coefficients between oxidative status traits and immune traits (P<0.001) were found, although at a very low level; and surprisingly, only ROS and SBA did not show any significant correlation. In this study it emerged that, even in the absence of evident pathologies, the immune and oxidative traits of fattening rabbits could be affected by environmental stress (weaning, cage, neighbors).

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Section: Resultssupporting

confidence: 69%

Native immunity and oxidative traits of growing rabbits

Moscati¹,

Bosco²,

Battistacci³

et al. 2010

World rabbit sci.

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“…7 Additionally, the fecal lysozyme concentrations found in patients with diarrhea as a result of causes other than IBD are elevated. 3,7 This reduces the clinical utility of this test, and based on current evidence there is little to support the use of fecal lysozyme as a diagnostic or monitoring tool for IBD.…”

Section: Lactoferrinmentioning

confidence: 98%

“…20,32 Lysozyme Lysozyme, also known as muramidase, is produced by leukocytes, macrophages, and intestinal epithelial cells in IBD. 3 As a result, the excretion of lysozyme is increased in patients with IBD, particularly in those with colitis. 3,4,7 In CD, the correlation of fecal lysozyme with clinical measures of disease activity, such as Crohn's disease activity index, is weak (r = 0.32, P = 0.001).…”

Section: Lactoferrinmentioning

confidence: 99%

“…3 As a result, the excretion of lysozyme is increased in patients with IBD, particularly in those with colitis. 3,4,7 In CD, the correlation of fecal lysozyme with clinical measures of disease activity, such as Crohn's disease activity index, is weak (r = 0.32, P = 0.001). 7 When subgroup analysis is performed on patients with colonic CD, the correlation improves (r=0.43, P=0.036).…”

Section: Lactoferrinmentioning

confidence: 99%

“…1 Several candidate leukocyte-derived proteins have been identified, including fecal calprotectin (FC), lactoferrin (FL), myeloperoxidase, lysozyme, elastase, eosinophil cationic protein (ECP), eosinophil protein X (EPX), and human neutrophil lipocalin (HNL). [1][2][3][4][5][6][7][8][9] Serum proteins, such as α1-antitrypsin, also appear in the feces in increased quantities in IBD sufferers. 10 Early studies of these markers examined whole gut lavage techniques to obtain clear fecal specimens for analysis to avoid fecal bacterial degradation of proteins.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Review of Fecal Biomarkers in Inflammatory Bowel Disease

Sutherland¹,

Gearry²,

Frizelle³

2008

Diseases of the Colon &Amp; Rectum

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The effect of high-dose methotrexate on renal tubules as indicated by urinary lysozyme concentration

Freeman-Narrod

Kim

Ohanissian

et al. 1982

Cancer

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Lysozyme was measured after 186 doses of methotrexate (MTX) to 88 patients. After 7.5% of the doses, lysozyme rose to between 2 and 19 m̈g/cc and in 3.2% it rose to between 20 and 120 m̈g/cc. These increases had no relationship to the age of the patients, their dose of MTX, the total number of times that MTX had been given, nor to rises in serum creatinine. It did correlate with the administration of aminoglycosides (a part of the supportive care of these patients) in two thirds of these cases. In the patients who did not receive aminoglycosides, no urinary lysozyme concentration rose above 19 m̈g/cc, not even in the patients who became oliguric or required hemoperfusion. Most of these rises occurred early and were of 24 to 48 hour duration. The rises occurring after five days were persistent and were associated with prolonged MTX serum concentrations, suggesting that tubular damage due to MTX was the result of prolonged exposure to MTX, rather than the primary cause of kidney damage, i.e., the event causing the prolonged serum concentrations.

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Serum and faecal lysozyme in inflammatory bowel disease.

Cited by 41 publications

References 26 publications

Native immunity and oxidative traits of growing rabbits

Native immunity and oxidative traits of growing rabbits

Review of Fecal Biomarkers in Inflammatory Bowel Disease

The effect of high-dose methotrexate on renal tubules as indicated by urinary lysozyme concentration

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