Immunohistochemical Localization of Blood-Retinal Barrier Breakdown Sites Associated with Post-Surgical Macular Oedema

Vinores, Stanley A.; Amin, Aana; Derevjanik, Nancy L.; Green, W. R.; Campochiaro, P. A.

doi:10.1097/00006982-199501560-00017

Cited by 39 publications

(49 citation statements)

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“…There was not an active infection in this study, and other elements of inflammation were not analyzed. Significant localization of serum albumin in both the inner and outer blood retinal barriers has been reported in human cases of endophthalmitis (Vinores, et al, 1994). As stated earlier, neutrophils enter the posterior segment at about the time that inflammatory cytokines are detected during experimental bacterial endophthalmitis (Giese, et al, 1998;Ramadan, et al, 2006).…”

Section: Blood Retinal Barrier Permeabilitymentioning

confidence: 82%

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Callegan

Gilmore

Gregory

et al. 2007

Progress in Retinal and Eye Research

156

153

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Endophthalmitis is an infection of the posterior segment of the eye that frequently results in loss of vision. This devastating result occurs despite prompt and often aggressive therapeutic and surgical intervention. Over the past decade, research has centered on determining the bacterial and host factors involved in this potentially blinding disease. The initial focus on the bacterial factors responsible for intraocular virulence has recently expanded into analysis the inflammatory response to infection, including the molecular and cellular interactions between the pathogen and host. This review discusses the epidemiology and therapeutic challenges posed by endophthalmitis, as well as recent findings from the analysis of interactions between the host and pathogen. Based on these findings, a model for the pathogenesis of endophthalmitis is presented. A more comprehensive understanding of the molecular and cellular interactions taking place between pathogen and host during endophthalmitis will expose possible therapeutic targets designed to arrest the infection and prevent vision loss.

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Section: Blood Retinal Barrier Permeabilitymentioning

confidence: 82%

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Callegan

Gilmore

Gregory

et al. 2007

Progress in Retinal and Eye Research

156

153

View full text Add to dashboard Cite

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“…13 Postoperative macular oedema is explained by the damage of the blood-retinal barrier. 14,15 On the other hand, no correlation was found between the inflammatory signs in the anterior chamber ('flare') and macular thickness. According to their opinion, damage of the blood-retinal barrier and consequent thickening of the macular area may happen without the damage of the blood aqueous barrier.…”

Section: Eyementioning

confidence: 99%

Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation

Bíró

Balla

Kovàcs

2006

Eye

118

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Purpose Cataract surgery is known to elicit postoperative macular oedema owing to its traumatic effect. The aim of the study was to measure the foveal and perifoveal thickness of the retina after uneventful phacoemulsification and posterior chamber intraocular lens (PC-IOL) implantation. Methods Retinal thickness values of the foveal and perifoveal (fovea þ 3.0 mm, fovea þ 6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 71 eyes of 71 patients (34 men, 37 women, mean age: 68.8 years) who underwent cataract surgery. Phacoemulsification and 'in the bag' implantation of a foldable PC-IOL was performed under topical anaesthesia. Data were collected 1 day before the operation, and postoperatively at 1, 7, 30, and 60 days. Contralateral eyes of each patient served as controls. 'Student's t-test' was used for statistical analysis, and Po0.05 value was considered significant.

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“…16 Postoperative macular oedema is explained by the damage of the blood-retinal barrier. 17,18 On the other hand, no correlation was found between the inflammatory signs in the anterior chamber ('flare') and macular thickness. According to their opinion, damage to the blood-retinal barrier and consequent thickening of the macular area may happen without the damage of the blood/aqueous barrier.…”

mentioning

confidence: 99%

OCT measurements on the foveal and perifoveal retinal thickness on diabetic patients after phacoemulsification and IOL implantation

Bíró

Balla

2009

Eye

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Purpose The first aim (I.) was to measure the change of macular thickness in diabetic (DM group) and nondiabetic patients (NORMAL group), the values of operated eye (OP) were compared I.A.) to the fellow, non-operated eye (CONTROL) and I.B.) to preoperative baseline value of the operated eye (PRE). The second aim (II.) was to compare postoperative macular thickening of DM group to NORMAL group eyes. Methods Retinal thickness values of the foveal and perifoveal (fovea þ 3.0 mm, fovea þ 6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 18 eyes of 18 diabetic patients and 53 eyes of 53 nondiabetic patients who underwent uneventful cataract surgery. Data were collected on the preoperative day and on postoperative 1, 7, 30, and 60 days. Student's t-test was used for statistical analysis.Results No significant change of the thickness values could be measured one day after surgery. However, a significant increase could be detected on the postoperative 7, 30, and 60 days in the perifoveal 3.0 mm and 6.0 mm sectors either calculated alone or averaged together with the foveal values. The initial (preoperative) average value of 232.7 ± 3.5 lm (mean ± SEM, n ¼ 144) in the 6.0 mm perifoveal region increased to 246.0 ± 8.2 lm (mean ± SEM, n ¼ 120, P ¼ 0.032) one week, to 249.9±5.1 lm (n ¼ 112, P ¼ 0.017) one month, and to 249.5±6.2 lm (n ¼ 104, P ¼ 0.009) 2 months after surgery. DiscussionOur results indicate that diabetes did not influence significantly the thickening of the macular regions after uncomplicated cataract surgery.

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Immunohistochemical Localization of Blood-Retinal Barrier Breakdown Sites Associated with Post-Surgical Macular Oedema

Cited by 39 publications

References 0 publications

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation

OCT measurements on the foveal and perifoveal retinal thickness on diabetic patients after phacoemulsification and IOL implantation

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