1992
DOI: 10.1016/0165-3806(92)90004-g
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Immunohistochemical localization of fibronectin-like protein in the inner ear of the developing gerbil and rat

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Cited by 39 publications
(26 citation statements)
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“…An understanding of the mechanisms by which these afferent connections are constructed will require additional study. However, it is of interest to note that fibronectin-like protein, a substrate adhesion molecule known to be important in neurite guidance (34), is transiently expressed within the extracellular spaces below gerbil IHCs and OHCs from birth to P4 (35), the time period during which these nonspecific afferent arbors are forming.…”
Section: Discussionmentioning
confidence: 99%
“…An understanding of the mechanisms by which these afferent connections are constructed will require additional study. However, it is of interest to note that fibronectin-like protein, a substrate adhesion molecule known to be important in neurite guidance (34), is transiently expressed within the extracellular spaces below gerbil IHCs and OHCs from birth to P4 (35), the time period during which these nonspecific afferent arbors are forming.…”
Section: Discussionmentioning
confidence: 99%
“…In the rat, gerbil, and mouse, fibronectin is abundant in the basilar membrane but is largely absent from around cells in the organ of Corti (Woolf et al, 1992;Cosgrove and Rodgers, 1997). However, during a short interval of a few days, the protein accumulates in the synaptic region beneath both types of hair cells (Woolf et al, 1992). Fibronectin and laminin exist in the spiral ganglion of the mouse during development (Woolf et al, 1992;Cosgrove and Rodgers, 1997).…”
mentioning
confidence: 98%
“…In the bird hearing organ, the basilar papilla, neither fibronectin nor laminin is detected along the growth routes of nerve fibers, although fibronectin exists beneath the hyaline cells (Richardson et al, 1987;Hemond and Morest, 1991;Cotanche and Messana, 1996). In the rat, gerbil, and mouse, fibronectin is abundant in the basilar membrane but is largely absent from around cells in the organ of Corti (Woolf et al, 1992;Cosgrove and Rodgers, 1997). However, during a short interval of a few days, the protein accumulates in the synaptic region beneath both types of hair cells (Woolf et al, 1992).…”
mentioning
confidence: 98%
“…With respect to the other ECM candidates, strong expression of FN has been documented immediately beneath the inner and outer HCs, in the rat cochlea from E18 through P1 [Woolf et al, 1992]. Kim [pers.…”
Section: Discussionmentioning
confidence: 99%
“…Besides these diffusable molecules, the inner ear tissue of the developing mammal contains a dynamic arrangement of insoluble glycoproteins such as laminin-1 (LN), tenascin-C (TN) and fibronectin (FN) in the extracellular matrix (ECM). The temporal and spatial expression patterns of ECM molecules have been suggested to influence reactions such as differentiation, morphogenesis, process outgrowth and substrate attachment by interacting with receptors on the surfaces of cochlear neurons [Woolf et al, 1992;Cosgrove and Rodgers, 1997;Whitlon et al, 1999a, b], but the influence of LN and TN on the outgrowth of SG neurites has not been investigated to date.…”
Section: Introductionmentioning
confidence: 99%