Immunohistochemical localization of renin and angiotensin II in human ovaries

Palumbo, Angela; Jones, Craig; Lightman, Abraham; Carcangiu, M. L.; DeCherney, Alan H.; Naftolin, Frederick

doi:10.1016/0002-9378(89)90077-x

Cited by 72 publications

(37 citation statements)

References 19 publications

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“…In the ovary, renin has been demonstrated by immunohistochemical staining in the theca cells of the mature follicle 7 and in the corpus luteum. 111 Specific high affinity Ang II receptors have been identified in these areas, as well as on granulosa cells in the rat ovary. 109 Ang II may affect progesterone production in the human ovary.…”

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confidence: 99%

Human prorenin.

1991

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Human prorenin is the enzymatically inactive biosynthetic precursor of renin. Recent interest has focused on the posttranslational sorting and processing of prorenin to renin since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. These observations raise the question of whether prorenin processing may be a regulatory event in renin production in the kidney. In the juxtaglomerular cells of the kidney, prorenin can be sorted to either of two pathways: 1) the regulated pathway, which is mediated by secretory granules, where a thiol protease resembling cathepsin B processes prorenin to renin by cleavage of the amino terminal 43-amino acid prosegment, which allows exposure of the active site of renin, or 2) the constitutive pathway, which is not regulated and does not involve conversion of prorenin to renin. Studies in which segments of prorenin are modified by site-directed mutagenesis suggest that the prosegment and glycosylation are not required for sorting, although they may influence or participate in sorting, or both. Certain areas in the prosegment are important determinants of enzyme activity and ability to cleave the prosegment. Further structural analysis of prorenin will be useful to assess details of its sorting and processing. In addition, a number of extrarenal tissues such as uterine lining, ovarian theca, corpus luteum, pituitary, and adrenal, express the renin gene. These tissues have different capabilities to sort and process prorenin compared with kidney, and some tissues secrete only prorenin. Whether prorenin-to-renin conversion is necessary to activate these local renin-angiotensin systems is a key issue. Understanding mechanisms involved in prorenin-torenin conversion will help to dissect the potential regulatory role of this step in renin secretion, to define the physiological importance of extrarenal prorenin and renin production, and to determine whether the prorenin processing step could be a site for therapeutic intervention. (Hypertension 1991;17:469-479)

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confidence: 99%

Human prorenin.

1991

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“…En outre, il a été démontré que l'angiotensine Il stimule la sécrétion de l'hormone placentaire lactogène (hPL) par des cellules trophoblastiques , la sécrétion de la prolactine par des cellules adénohypophysaires (Platia et al, 1986;Myers et Steele, 1989) et la biosynthèse des hormones stéroïdes par les cellules de la granulosa (Pucell et al, 1987;Guichard et al, 1988;Palumbo et al, 1989 (Cooke et al, 1981;Wilkes et al, 1985;Kurauchi et al, 1990 (Munson et Rodbard, 1980;Whitebread et al, 1989) (Whitebread et al, 1989).…”

Section: Introductionunclassified

Les récepteurs de l'angiotensine II dans le placenta humain sont de type AT₁

Kalenga

Gasparo²,

Hertogh³

et al. 1991

Reprod. Nutr. Dévelop.

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“…In the rat, renin mRNA has been detected in cells of the corpus luteum. 65 However, ovarian renin appears to be produced by theca, stromal, and luteal cells in humans, 83 and human theca cells in culture. 84 Low levels of renin mRNA are visible by Northern blotting of total RNA from C57BL/6 ovaries (CD.…”

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confidence: 99%

Structure, expression, and regulation of the murine renin genes.

1991

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It has long been known that the renin-angiotensin system plays an integral role in the regulation of blood pressure and electrolyte and fluid balance in mammals. The advent of molecular biologic techniques has afforded new insights into the genes regulating blood pressure. Laboratory mice and rats have been used as experimental models to examine the structural organization and expression of the renin gene. It is now well established that some mice, unlike rats and humans, contain a duplicated copy of the renin locus, which accounts for the high level of renin activity long known to be found in the submandibular gland of some mice. Indeed it is this fortuitous observation that facilitated the isolation of the first complementary DNA clones for renin and ultimately the many species-specific probes now available to analyze mammalian tissues for evidence of primary renin expression. The use of complementary DNAs as probes for primary renin expression helped confirm and further clarify earlier studies demonstrating the presence of renin activity in a number of extrarenal tissues. Although expression in some of these tissues is evolutionarily conserved, their significance has still been elusive. In this report we review the impact of molecular biology on our current understanding of renin gene structure and organization, tissue-and cell-specific expression and regulation, and the changes in renin expression throughout ontogeny. In addition, we describe how new developments in gene transfer technology have added important tools to our arsenal for examining renin gene regulation and how these technologies can be used to develop new tools for renin and hypertension research. (Hypertension 1991;18:446-457)

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Immunohistochemical localization of renin and angiotensin II in human ovaries

Cited by 72 publications

References 19 publications

Human prorenin.

Human prorenin.

Les récepteurs de l'angiotensine II dans le placenta humain sont de type AT₁

Structure, expression, and regulation of the murine renin genes.

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Immunohistochemical localization of renin and angiotensin II in human ovaries

Cited by 72 publications

References 19 publications

Human prorenin.

Human prorenin.

Les récepteurs de l'angiotensine II dans le placenta humain sont de type AT1

Structure, expression, and regulation of the murine renin genes.

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Les récepteurs de l'angiotensine II dans le placenta humain sont de type AT₁