Immunohistochemical study of a canine neurofibroma

Abstract

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

Sudden death due to rupture of the right internal carotid artery in neurofibromatosis type 1: A case report

“…They are positive for S-100 protein at IHC analysis, indicating their neural origin from Schwann cells [8]. Furthermore, positivity for vimentin and CD34 are also indicative of neurofibromas [9,10]. In this case, neurofibromas were demonstrated by macroscopic, histopathological and immunohistochemical characteristics.…”

Peripheral nerve sheath tumor invading the nasal cavities of a 6-year-old female Pointer dog

“…Furthermore, these studies showed that similarities between neurofibroma in animals and humans are not restricted to microscopic features, but that they also exist in regard to tumor location and patient's age (Schoniger & Summers 2009). After publication of the report by Schoniger and Summers (2009), a real neurofibroma in the neck of a dog was described (Fattahian et al 2012). In humans, PNST are usually benign neoplasm.…”