Immunohistochemical Study of Vasculogenic Mimicry and Angiogenesis in Melanocytic Tumors of the Eye and the Periocular Area

Spiliopoulos, Konstantinos; Peschos, Dimitrios; Batistatou, Anna; Ntountas, Ioannis; Papoudou‐Bai, Alexandra; Zioga, Aikaterini; Agnantis, Niki J.; Kitsos, Georgios

doi:10.21873/anticanres.11424

Cited by 6 publications

(3 citation statements)

References 20 publications

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“… 17 , 27 In benign nevi, IHC analysis of VM was shown in a minority of cases as compared to that of melanomas and was associated with unfavorable survival. 60 In a patient diagnosed with multiple probable cerebral cavernous malformations, a slightly enlarged hyperintense region on the right frontal lobe persisted after therapy. Postoperative histological diagnosis demonstrated an anaplastic oligodendroglioma and cerebral cavernous malformations with VM.…”

Section: Introductionmentioning

confidence: 99%

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

Luo

2018

CMAR

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Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer.

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Section: Introductionmentioning

confidence: 99%

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

Luo

2018

CMAR

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“…However, the expression of EPH receptor A2 (EphA2), a potential indicator of VM formation, was not remarkably regulated after overexpressing L1 in glioma cells, suggesting that the EphA2 signal might not be associated with L1‐mediated VM formation in glioma. Similarly, immunofluorescence staining further confirmed that the expression of CD31 and CD34, which are the key biomarkers in the VM formation process [48,49], was significantly increased in L1‐overexpressing T98 and GBM1 cells (Fig. 3C).…”

Section: Resultsmentioning

confidence: 59%

L1CAM promotes vasculogenic mimicry formation by miR‐143‐3p‐induced expression of hexokinase 2 in glioma

et al. 2023

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In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition to tumor cells, has become a promising clinical strategy for the treatment of patients with tumors. However, recent studies revealed that vasculogenic mimicry (VM), which is the process by which vascular morphological structures are formed by highly invasive tumor cells, has been considered a potential factor for the failure of antiangiogenic therapy in patients with tumors. Thus, inhibition of VM formation might be a potential target for improving the outcome of antiangiogenic strategies. However, the mechanism underlying VM formation is still incompletely elucidated. Herein, we report that L1CAM might be a critical regulator of VM formation in glioma, and might be associated with the resistance of glioma to antiangiogenic therapy. We found that the tumor‐invasion and tube‐formation capabilities of L1CAM ‐overexpressing cells were significantly enhanced in vitro and in vivo . In addition, the results indicated that miR‐143‐3p, which might directly target the 3'UTR of the hexokinase 2 ( HK2 ) gene to regulate its protein expression, was subsequently involved in L1CAM‐mediated VM formation by glioma cells. Further study revealed that the regulation of MMP2 , MMP9, and VEGFA expression was involved in this process. Moreover, we identified that activation of the downstream PI3K/AKT signaling pathway of the L1CAM/HK2 cascade is critical for VM formation by glioma cells. Furthermore, we found that the combined treatment of anti‐L1CAM neutralizing monoclonal antibody and bevacizumab increases efficacy beyond that of bevacizumab alone, and suppresses glioma growth in vivo , indicating that the inhibition of L1CAM‐mediated VM formation might efficiently improve the effect of antiangiogenic treatment for glioma patients. Together, our findings demonstrated a critical role of L1CAM in regulating VM formation in glioma, and that L1CAM might be a potential target for ameliorating tumor resistance to antiangiogenic therapy in glioma patients.

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“…It is likely that melanocytic malignant tumors such as melanoma arising from the ocular regions revealed more vascular-rich nature than non-malignant melanocytic tumors (9). In this study, in aspirating the iris tumor tissue for the diagnosis, intraoperative and postoperative bleeding was not apparent in the anterior chamber, suggesting that metastatic iris tumors might be characterized by hypovascular non-melanocytic tumors.…”

Section: Discussionmentioning

confidence: 65%

A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy

Mitamura

Kase

Suimon

et al. 2020

In Vivo

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Background/Aim: Metastatic iris tumors are relatively rare entities that are often treated with radiation therapy; however, it remains difficult to evaluate the effectiveness of treatment. Anterior segment optical coherence tomography (AS-OCT) provides high-resolution crosssectional images with no dye injection, and may thus be useful for evaluating iris tumors. Herein, we report a case of metastatic iris tumor examined with AS-OCT before and after radiation therapy. Case Report: A 56-year-old Japanese woman complained of ocular hyperemia and pain in her right eye, and was referred to our hospital because of uveitis and an iris mass. One year before the initial visit, the patient was diagnosed with lung adenocarcinoma, and treated with chemotherapy. She also underwent radiation therapy 4 months ago due to multiple bone metastases. Slit-lamp microscopy revealed a 2×2 mm elevated lesion with partial depigmentation on the lower iris. AS-OCT examination revealed that the mass was located in the iris stroma with an irregular anterior surface. Based on fine needle aspiration cytology, she was diagnosed with metastatic iris tumor derived from lung adenocarcinoma, leading to local radiotherapy. Seven months later, AS-OCT showed shrinkage and atrophy of the iris tumor with peripheral anterior synechia formation. Conclusion: We report a case of cytology-proven metastatic iris tumor observed with AS-OCT before and after radiation therapy. This study highlights the potential usefulness of AS-OCT for monitoring changes in tumor size and configuration following radiotherapy.

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Immunohistochemical Study of Vasculogenic Mimicry and Angiogenesis in Melanocytic Tumors of the Eye and the Periocular Area

Abstract: The existence of vasculogenic mimicry in benign nevi might have prognostic implications.

Cited by 6 publications

References 20 publications

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

L1CAM promotes vasculogenic mimicry formation by miR‐143‐3p‐induced expression of hexokinase 2 in glioma

A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy

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Immunohistochemical Study of Vasculogenic Mimicry and Angiogenesis in Melanocytic Tumors of the Eye and the Periocular Area

Abstract: The existence of vasculogenic mimicry in benign nevi might have prognostic implications.

Cited by 6 publications

References 20 publications

Overview of advances in vasculogenic mimicry &ndash; a potential target for tumor therapy

Overview of advances in vasculogenic mimicry &ndash; a potential target for tumor therapy

L1CAM promotes vasculogenic mimicry formation by miR‐143‐3p‐induced expression of hexokinase 2 in glioma

A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy

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Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy