Immunohistochemical Study on AFP, HCG and PLAP in Primary Intracranial Germ Cell Tumors

Washiyama, Kazuo; Sekiguchi, Kentaro; Tanaka, Ryuichi; Yamazaki, Kazunori; Kumanishi, Toshiro; Oyake, Y

doi:10.1159/000413687

Cited by 20 publications

(10 citation statements)

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“…Classically, secreting GCTs are defined as GCTs with cerebrospinal fluid (CSF) AFP >10 μg/l (or above the institutional normal range) and/or a CSF βHCG level >50 IU/l. Secreting GCTs are considered to be more aggressive and carry a poorer prognosis than non-secreting GCTs (5,6). A total of 73-86% of intracranial GCTs are pure germinomas.…”

Section: Discussionmentioning

confidence: 99%

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Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy

Scherz

Feller

Berezowska

et al. 2017

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We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Magnetic resonance imaging of the brain showed a 14×8.4 mm enhancing lesion of the pituitary stalk and histopathology of the neurosurgical biopsy confirmed pituitary germinoma. The patient was treated with 3 cycles of chemotherapy, consisting of 150 mg/m etoposide and 75 mg/m cisplatin, with the administration of intrathecal 12.5 mg methotrexate, on day one, alternating every 10 to 11 days with 1 mg/m vincristine, 1,000 mg/m methotrexate on day 1 and 30 mg/m bleomycin on day 2. MRI scans showed lasting complete remission more than a year after completion of chemotherapy. Intracranial germinomas are exquisitely sensitive to radiation. However, due to concerns of side-effects (radiation-associated tumour, relapse outside the radiation field, mental and pituitary hormonal dysfunction), and after discussing both approaches carefully with the patient, the decision was made to treat his pituitary germinoma with chemotherapy alone. Further studies should address the question as to whether a modulated approach, using radiotherapy only as a salvage in patients with relapse, might result in a better overall outcome, given the potentially harmful long-term side-effects of radiotherapy to the brain.

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Section: Discussionmentioning

confidence: 99%

“…They are generally non-secreting, although a small proportion may correlate with elevated βHCG level in the CSF or serum. An elevated βHCG level is ascribed to syncytiotrophoblasts that may be scattered within germinomas (5,6).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy

Scherz

Feller

Berezowska

et al. 2017

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“…It was di cult to distinguish with cerebellum glioma, hemangioblastoma and medulloblastoma. The diagnosis was depending on the combination of elevated AFP and histopathological examination (9,21). There are various reports of current treatment options of intracranial germ cell tumors (7).…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

Zhang

Ling

2020

Preprint

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Abstract Background: Yolk sac tumor also known as endodermal sinus tumor, is a rare intracranial germ cell tumor. We reported a case of yolk sac tumor in cerebellar hemisphere, and reviewed associated literatures. The majority of tumor locations are near the midline. On review of literature, very few case reports of intracranial yolk sac tumor have been published, and there is only one case report has described a yolk sac tumor arising from the cerebellum. Case presentation: A two years old boy admitted to our hospital due to headache and unsteady gait for six days. CT and MRI demonstrated a tumor in the right cerebellar hemisphere, and the blood and cerebrospinal fluid alpha-fetoprotein were found increased. It was diagnosed as yolk sac tumor after operation comfirmed by histopathological examination. Postoperative chemotherapy was performed, and the patient suffered no tumor recurrence one year and a half after the surgery. Conclusions: The clinical characteristics and imaging diagnosis of intracranial yolk sac tumor are lack of specificity, the comfirmed diagnosis is depending on the combination of elevated alpha-fetoprotein and histopathological examination.

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“…In GCT, hCG positivity can be seen in all of the choriocarcinomas and other types of GCT that contain this cell type [5,[14][15][16][17]. The crossreactivity of hCG with the TSH and LH receptors leads to thyroidal and gonadal stimulation and therefore its secretion can initially mask the concomitant development of hypopituitarism [7,9,11].…”

Section: Discussionmentioning

confidence: 99%

Pituitary choriocarcinoma in an adolescent male: Tumor-derived CG and GH delay diagnosis

Wildi-Runge

Crevier²,

Carret

et al. 2011

Growth Hormone & IGF Research

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Immunohistochemical Study on AFP, HCG and PLAP in Primary Intracranial Germ Cell Tumors

Cited by 20 publications

References 0 publications

Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy

Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy

A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

Pituitary choriocarcinoma in an adolescent male: Tumor-derived CG and GH delay diagnosis

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