Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

Park, J. K.; Goo, Moon-Jung; Hong, I. H.; Ki, Mi-Ran; Han, Jung Yeon; Jeong, Kyu Shik

doi:10.1111/j.1439-0531.2008.01135.x

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…We have also noticed several cavities within the tumor mass. The size of the formation, as established by ultrasonography, was about 7 cm, a size similar to reports by Park et al (14) and Rolim et al (15). The cornified epithelial cells observed on the cytovaginal smear correlated to high blood estradiol concentration (86 pg/ml).…”

Section: Discussionsupporting

confidence: 89%

“…Features specifi c for this tumor are the presence of rather large neoplastic cells of polyhedral shape, resembling the primitive germ cells (1,7,15). Immunohistochemistry could be an alternative for diagnosing this neoplasm (14,15).…”

Section: Discussionmentioning

confidence: 99%

“…Metastases of this cancer have been observed in lymph nodes, brain, liver, kidneys, adrenal glands, omentum, serous intestinal tract surface, lungs and retroperitoneal space (3,6,13). The age of the dogs with ovarian dysgerminoma ranges between 2 and 15 years (1,6,13,14), but a breed predilection has not been established. There are single reports for simultaneous ovarian dysgerminoma and pyometra in the bitch, but to our best knowledge, there is no detailed description of ultrasound findings and blood hormonal profile, namely serum progesterone and estradiol.…”

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confidence: 99%

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A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

Antonov

Fasulkov

Simeonov

2014

Macedonian Veterinary Review

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A clinical case of an 11-year-old bitch with unilateral ovarian dysgerminoma and pyometra is described. The owner reported purulent discharge from external genitalia, fastidious appetite and depression. Transabdominal ultrasonography of the reproductive organs showed a hypoechoic mass in the region of the left ovary (7.18 × 6.65 cm) and a strongly enlarged uterine lumen full of anechoic fluid. Vaginal cytology demonstrated about 50% superficial cornfield epithelial cells and multiple neutrophils. Complete blood counts and blood biochemistry analysis indicated a significant leukocytosis and a mild anemia. Blood progesterone (3.96 ng/ml) and estradiol (86 pg/ml) were assayed. Median laparotomy revealed an enlarged uterus, substantially altered left ovary, of the size of a grapefruit. The right ovary was of normal size and structure. Tumor metastases in other organs were not seen. Histologically, diffusely located cancer cells resembling primitive germ cells, specific for dysgerminomas, were established. One year after the surgery, according to the owner the dog is vital, with normal appetite and without general condition abnormalities.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

Antonov

Fasulkov

Simeonov

2014

Macedonian Veterinary Review

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“…Different types of tumors can be identified by immunohistochemistry. Neoplastic cells in dysgerminomas are positive for vimentin, and alkaline phosphatase, and negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-a and S-100 (PARK et al, 2009). Ovariohysterectomy is the treatment of choice (ANTONOV et al, 2014).…”

Section: Sollier and Caquiasmentioning

confidence: 99%

Canine ovarian dysgerminoma

Podestá

Caquias

2020

Cienc. Rural

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This research aimed to describe a clinical case of ovarian dysgerminoma in a bitch, by showing clinical, ultrasound, surgical and pathological findings. The research also sought to emphasize the importance of establishing an early and definitive diagnosis through histopathology, establishing appropriate protocols for each patient. Ovarian tumors have a low incidence in dogs and cats. Dysgerminomas are a type of ovarian germ cell tumor. They develop in dogs of variable age, that may present clinical signs of hormonal imbalance such as persistent estrus, or pyometra. Prognosis is good in animals that undergo surgery and show no evidence of metastasis. This article presents a clinical case of a 6-year-old English Bulldog with persistent estrus for 2 months, and slightly depressed mental state. Ultrasound revealed the presence of a mass on the left ovary and uterine content. Ovariohysterectomy was performed and the mass was submitted to histopathological exam, which diagnosed an ovarian dysgerminoma.RESUMO: Neste trabalho descrevem-se caso clínico, achados de ultrassom, cirúrgicos e patológicos de disgerminoma ovárico em cadela. Os tumores ováricos têm baixa incidência em cães e gatos. Nesta categoria estão os tumores das células germinativas, a partir das quais se desenvolvem os disgerminomas. Acomete cadelas de idades variáveis, que podem apresentar sinais clínicos indiciando alterações hormonais, como cio persistente, ou piometra. O prognóstico em animais tratados cirurgicamente, sem evidência de metástase, é bom. Esta pesquisa relata um caso clínico em cadela, raça Bulldog Inglês, de 6 anos de idade, com presença de cio persistente por dois meses. O ultrassom revelou a presença de massa ao nível do ovário esquerdo e escasso conteúdo uterino. Foi realizada ovariohisterectomia e a peça cirúrgica foi enviada para anatomia patológica, que diagnosticou disgerminoma ovarico. Após a resolução do caso, ressalta-se a importancia do diagnóstico clinico e histopatológico precoce para estabelecer protocolos de tratamento adequados. Palavras-chave: neoplasias ovaricas, disgerminoma, tumor canino. CLINIC AND SURGERY

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“…Ovarian masses range from 2 to 30 cm, with an average size of 9.5 cm. They are usually broad nodular masses, mostly unilateral, whose growth results in increased volume and spherical or ovoid shape of the affected ovary (MacLachlan and Kennedy 2002;Park et al 2008;Novotny et al 2011). Bilateral dysgerminomas are extremely rare (Patnaik and Greenlee 1987;Rolim et al 2010).…”

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confidence: 99%

Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

et al. 2018

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Dysgerminomas are infrequent neoplasms resulting from undifferentiated germinal cells, mainly observed in the bitch. Our case describes for the first time a dysgerminoma related splenic metastasis in a bitch. A 14-year-old crossbred bitch was admitted at our facility with a 3-month history of irregular oestrous cycle, vulvar swelling, haemorrhagic vaginal discharge, lethargy and anorexia. Cytological examination showed the presence of superficial epithelial cells of the vaginal mucosa with a high degree of cornification. Vaginoscopy showed the typical pale and crenulated mucosal folds (oestrus). Haematological analysis indicated moderate anaemia and leukocytosis, and increased level of oestrogen. Ultrasound examination showed a mass located caudally to the kidney in the region of the right ovary. Abdominal and thoracic radiographs confirmed the findings and did not reveal metastases. Suspecting an ovarian tumour, we decided to perform a complete ovariohysterectomy. Once located, the right ovary presented an increased volume, irregular shape and reddish colour. Samples collected during the procedure were stained with haematoxylin and eosin and observed under optical microscope. The cells were characterized by a scant cytoplasm, a large vesicle type nucleus with coarsely granular chromatin and distinct cell borders. The neoplastic cells were remarkably similar to those of a testicular seminoma, allowing for the diagnosis of ovarian dysgerminoma. Two years after the ovariohysterectomy, the owner reported history of increased volume of the abdomen and lethargy. A second surgery was performed during which an irregular splenic mass was found. The morphological diagnosis was “splenic metastasis of dysgerminoma”. To the authors' knowledge, dysgerminoma related splenic metastasis was never described in the bitch before.

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Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

Cited by 15 publications

References 16 publications

A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

Canine ovarian dysgerminoma

Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

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