Immunohistological study of involucrin expression in Darier's disease skin

Abstract

DD skin displayed a constant immunohistochemical involucrin pattern characterized by both premature expression and a particular cytoplasmic/cell membrane localization distribution.

Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease

“…1d); this is consistent with a previous report by Aberg et al. 18 In line with these data, immunohistological studies of involucrin expression in skin samples from patients with HHD revealed reduced involucrin expression 19 . Taken together, our data and that of other groups indicate that HHD keratinocytes derived from lesional skin retain their cell‐specific characteristics in culture.…”

In vitro biocompatibility of poly(vinylidene fluoride–trifluoroethylene)/barium titanate composite using cultures of human periodontal ligament fibroblasts and keratinocytes

“…In addition to changes in keratin expression, the expression of other proteins, such as involucrin, also characterizes terminal differentiated keratinocytes in lining epithelia [50]. Thus, the development of keratinocyte phenotype was assayed by gene expression of involucrin and keratins 1, 10 and 14.…”

Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis

“…Keratinocytes and epidermis form a unique model to study ER stress, particularly ER stress due to ER Ca 2+ depletion. Profound ER Ca 2+ depletion, caused by a variety of mutations in the ER Ca 2+ ATPase ATP2A2 (protein SERCA2), leads to Darier disease, a skin condition characterized by defective keratinocyte differentiation, abnormal keratinocyte apoptosis and impaired cell‐to‐cell adhesion known as acantholysis 4–6 . When SERCA2 is inactivated in mice, altered differentiation leads to development of squamous cell carcinomas in these animals’ skin 7 .…”