Immunohistology of pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica

Wood, Gary S.; Strickler, John G.; Abel, Elizabeth A.; Deneau, David G.; Warnke, Roger A.

doi:10.1016/s0190-9622(87)70074-7

Cited by 57 publications

(31 citation statements)

References 21 publications

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“…Clinically as well as histopathologically we found no typical lymphomatoid papu losis. Even the immunopathology of the last available skin biopsies revealed nearly no CD30-positive cells or inflam matory infiltrates (9]. In the third patient PLC changed into an anaplastic, large-cell non-Hodgkin lymphoma of the skin after the skin lesions had persisted for over 10 years.…”

Section: Discussionmentioning

confidence: 91%

Atypical Manifestations of Pityriasis lichenoides chronica: Development into Paraneoplasia and Non-Hodgkin Lymphomas of the Skin

Panizzon

Speich

1992

Dermatology

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Three patients with atypical courses and manifestations of pityriasis lichenoides chronica (PLC) are presented. The first patient is a 21-year-old white woman who showed a good response of her PLC lesions as well as her reactive oligoarthritis to repeated PUVA treatments combined with oral prednisone during 1 year. The effect of the treatment then decreased. The patient developed a low-grade malignant lymphoma of the lung. When the lymphoma of the lung improved after chemotherapy, the PLC eruptions improved, too. The second patient is a 41-year-old man, whose Hodgkin’s disease stage IVa was successfully treated by chemotherapy and radiotherapy in 1984. In 1987 he showed PLC lesions which responded well to PUVA therapy, later also in combination with etretinate. Until 1988 repeated skin biopsies revealed a non-specific eczematous pattern. In 1989 the recalcitrant PLC eruptions finally revealed a pleomorphic non-Hodgkin lymphoma of the skin with medium-sized cells. The third patient had a PLC for about 9 years when Hodgkin’s disease stage la was diagnosed. At the beginning the skin biopsy showed an eczematous pattern, but 2 years later, in 1990, skin infiltrations of a large-cell, anaplastic non-Hodgkin lymphoma were seen. These cases show that PLC in rare cases may either represent a paraneoplastic skin disease or may itself develop into cutaneous lymphomas.

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Section: Discussionmentioning

confidence: 91%

Atypical Manifestations of Pityriasis lichenoides chronica: Development into Paraneoplasia and Non-Hodgkin Lymphomas of the Skin

Panizzon

Speich

1992

Dermatology

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“…In the study by Wood et al, 10 the only immunohistologic difference observed between PLEVA and PLC was the trend toward a predominance of CD8 + T cells in PLEVA, especially within the epidermis. They argued that a subset of infiltrating cells may be the primary target, with epidermal destruction representing a secondary event.…”

Section: Commentmentioning

confidence: 85%

“…Immunohistochemical analysis has found similarities in both entities. 10 Molecular characterization of the infiltrating cells in a small series of patients with PLEVA indicated that the lymphocytic infiltrate is lymphoproliferative in nature 11 and demonstrated a monoclonal population of T cells by Southern blot analysis of T-cell receptor(TCR) ␤ gene rearrangement. In addition, Panhans et al 12 described the case of a 7-year-old boy with atypical CD30-positive cells and a clonal TCR gene rearrangement by polymerase chain reaction (PCR) of TCRγ genes.…”

mentioning

confidence: 99%

The Clonal Nature of Pityriasis Lichenoides

Weinberg

Kristal²,

Chooback³

et al. 2002

Arch Dermatol

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“…The distinction between the chronic and acute forms of PL is not always clear as they appear to be interrelated both clinically and immunohistologically and are generally considered to exist along a clinicopathologic spectrum. 120,121 PL et varioliformis acuta PLEVA is a generalized cutaneous eruption of unknown cause, which is characterized by crops of erythematous papules that can become hemorrhagic, pustular, or necrotic. Typically the lesions are at different stages, because of the episodic nature of the eruption (Fig 9).…”

Section: Pityriasis Lichenoidesmentioning

confidence: 99%