Immunoinducible Carbon Dot-Incorporated Hydrogels as a Photothermal-Derived Antigen Depot to Trigger a Robust Antitumor Immune Response

Liu, Suwan; Zhang, Miaomiao; Yu, Huijun; Sun, Xin; Li, Qianzhe; Yang, Mengyu; Qiu, Xiaonan; Su, Hang; Gong, Aihua; Du, F.

doi:10.1021/acsami.2c18371

Cited by 28 publications

(22 citation statements)

References 42 publications

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“…[ 113 ] HMGB1 stimulates antigen presentation to T cells and triggers antigen‐specific immunotherapy. [ 114 ] Furthermore, in order to acquire more intense and durable immune response, PTT has been synergized with immune adjuvants (e.g., CpG oligodeoxynucleotides, and agonists), [ 113b,115 ] or various immune checkpoint inhibitors. [ 112,116 ] Thus, the term photothermal immunotherapy has been forged, and it describes the combination of the immunogenic properties of PTT and immunotherapy treatment.…”

Section: Tme Modulationmentioning

confidence: 99%

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Jia

Feng

et al. 2023

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Canonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H2O2, GSH, and proteases. To overcome the shortcomings of canonical phototherapy and achieve optimal theranostic effects with minimal side effects, unique TME characteristics are employed in the development of phototherapeutic nanomedicines. In this review, the effectiveness of three strategies for developing advanced phototherapeutics based on various TME characteristics is examined. The first strategy involves targeted delivery of phototherapeutics to tumors with the assistance of TME‐induced nanoparticle disassembly or surface modification. The second strategy involves near‐infrared absorption increase‐induced phototherapy activation triggered by TME factors. The third strategy involves enhancing therapeutic efficacy by ameliorating TME. The functionalities, working principles, and significance of the three strategies for various applications are highlighted. Finally, possible challenges and future perspectives for further development are discussed.

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Section: Tme Modulationmentioning

confidence: 99%

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Jia

Feng

et al. 2023

Small

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“…[10][11][12][13] Biomass Hydrogels have good biocompatibility and low toxicity, hydrophilicity, viscosity, elasticity, high water content, and tunable stiffness, conceived as a new practical, promising substrate for light-toheat conversion materials. The research of biomass hydrogel in antibacterial, [14,[124][125] drug release, [15] near-infrared photothermal therapy, [16,[126][127] seawater desalination, [17] and biopharmaceutical [18] has attracted increasing attention. Biomass hydrogel systems have obvious advantages in nearinfrared photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Photothermal Conversion of Hydrogel‐Based Biomaterial

Wei

et al. 2023

The Chemical Record

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Traditional energy from fossil fuels like petroleum and coal is limited and contributes to global environmental pollution and climate change. Developing sustainable and eco‐friendly energy is crucial for addressing significant challenges such as climate change, energy dilemma and achieving the long‐term development of human society. Biomass hydrogels, which are easily synthesized and modified, have diverse sources and can be designed for different applications. They are being extensively researched for their applications in artificial intelligence, flexible sensing, biomedicine, and food packaging. The article summarizes recent advances in the preparation and applications of biomass‐based photothermal conversion hydrogels, discussing the light source, photothermal agents, matrix, and preparation methods in detail. It also explores the use of these hydrogels in seawater desalination, photothermal therapy, antibacterial agents, and light‐activated materials, offering new ideas for developing sustainable, efficient, and advanced photothermal conversion biomass hydrogel materials. The article concludes with suggestions for future research, highlighting the challenges and prospects in this field and paving the way for developing of long‐lasting, efficient energy materials.

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“…The synthesis of CDs has remained a challenge, with low synthetic yields being a major issue. CDs possess unique properties such as fluorescence, good biocompatibility, and low toxicity, − making them useful in many fields such as sensing, − imaging, − catalysis, , drug delivery, − and device − applications. CDs have excellent fluorescence ability, and solid-state silane-functionalized CDs can be directly used as phosphors for multicolor light-emitting diodes and all types of white light-emitting diodes .…”

Section: Introductionmentioning

confidence: 99%

EGTA-Derived Carbon Dots with Bone-Targeting Ability: Target-Oriented Synthesis and Calcium Affinity

Liu,

Li,

et al. 2023

ACS Appl. Mater. Interfaces

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The bone-targeting mechanism of clinic bisphosphonate-type drugs, such as alendronate, risedronate, and ibandronate, relies on chelated calcium ions on the surface of the bone mineralized matrix for the treatment of osteoporosis. EGTA with aminocarboxyl chelating ligands can specifically chelate calcium ions. Inspired by the bone-targeting mechanism of bisphosphonates, we hypothesize that EGTA-derived carbon dots (EGTA-CDs) hold bone-targeting ability. For the target-oriented synthesis of EGTA-CDs and to endow CDs with bone targeting, we designed calcium ion chelating agents as precursors, including aminocarboxyl chelating agents (EGTA and EDTA) and bisphosphonate agents (ALN and HEDP) for the target-oriented synthesis of aminocarboxyl-derived CDs (EGTA-CDs and EDTA-CDs) and bisphosphonate-derived CDs (ALN-CDs and HEDP-CDs) with high synthetic yield. The synthetic yield of EGTA-CDs reached 87.6%. Aminocarboxyl-derived CDs and bisphosphonate-derived CDs retain the chelation ability of calcium ions and can specifically bind calcium ions. The chemical environment bone-targeting value coordination constant K and chelation sites of EGTA-CDs were 6.48 × 10 4 M −1 and 4.12, respectively. A novel method was established to demonstrate the bone-targeting capability of chelate-functionalized carbon dots using fluorescence quenching in a simulated bone trauma microenvironment. EGTA-CDs exhibit superior bone-targeting ability compared with other aminocarboxylderived CDs and bisphosphonate-derived CDs. EGTA-CDs display exceptional specificity toward calcium ions and better bone affinity than ALN-CDs, suggesting their potential as novel bone-targeting drugs. EGTA-CDs with strong calcium ion chelating ability have calcium ion affinity in simulated body fluid and bone-targeting ability in a simulated bone trauma microenvironment. These findings offer new avenues for the development of advanced bone-targeting strategies.

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Immunoinducible Carbon Dot-Incorporated Hydrogels as a Photothermal-Derived Antigen Depot to Trigger a Robust Antitumor Immune Response

Cited by 28 publications

References 42 publications

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Photothermal Conversion of Hydrogel‐Based Biomaterial

EGTA-Derived Carbon Dots with Bone-Targeting Ability: Target-Oriented Synthesis and Calcium Affinity

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