Immunoinflammation in Diabetic Nephropathy: Molecular Mechanisms and Therapeutic Options

López-Parra, Virginia; Mallavia, Beñat; Egido, Jesús; Gómez-Guerrero, Carmen

doi:10.5772/34541

Cited by 18 publications

(14 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DN is characterized by persistent microalbuminuria, decreased glomerular filtration (GFR) rate and increased albumin to creatinine ratio ( Reutens and Atkins, 2011 ). Glomerular changes such as thickening of capillary basement membrane, mesangial expansion and glomerulosclerosis are pathological indications of DN ( Patel and Santani, 2009 ; Lopez-parra et al, 2012 ). The recent reports endorse about 12–55% incidences of end stage renal disorders (ESRD) are attributed to diabetes ( WHO, 2016 ).…”

Section: Nf-κβ and Diabetic Nephropathymentioning

confidence: 99%

“…There are two sub types of macrophages; M1 and M2. M1 macrophages are involved in pro-inflammatory response while M2 macrophages are involved in tissue repair remodeling and angiogenesis process ( Schmid et al, 2006 ; Silva et al, 2011 ; Lopez-parra et al, 2012 ). In diabetic patient, increased AGEs and ROS burden activates leukocytes that release superoxide radicals and proteases in the kidney ( Mohamed et al, 1999 ; Patel and Santani, 2009 ).…”

Section: Nf-κβ and Diabetic Nephropathymentioning

confidence: 99%

“…Activation of NF-κβ up-regulate monocyte chemoattractant protein-1 (MCP-1) leading to macrophage infiltration ( Cha et al, 2005 ), renal injury and increased microalbuminuria in DN ( Lopez-parra et al, 2012 ). NF-κβ also enhances expression of TGF-β-activated kinase (TAK-1) from MAPK family known as MAP3K7.…”

Section: Nf-κβ and Diabetic Nephropathymentioning

confidence: 99%

See 2 more Smart Citations

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

2017

View full text Add to dashboard Cite

Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-κβ that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-α, interleukins, TGF-β, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-κβ is key risk factor in vascular dysfunction. NF-κβ over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-κβ pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-κβ have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-κβ as promising target in the management of vascular complications of diabetes.

show abstract

Section: Nf-κβ and Diabetic Nephropathymentioning

confidence: 99%

Section: Nf-κβ and Diabetic Nephropathymentioning

confidence: 99%

See 1 more Smart Citation

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

2017

View full text Add to dashboard Cite

show abstract

“…In spite of the efforts that have been made on the prevention and treatment of this disease, incidence of diabetes is reported to be further increased in future due to the changes in people's life style, such as Western-style diet structure [2]. Besides the abnormal physiological conditions caused by diabetes itself, complications of diabetes also seriously affect human health [3,4]. Diabetes usually leads to chronic renal failure [5,6].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway

Yang

Kan

et al. 2018

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

It's known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease. ROC curve analysis showed that serum level of CASC2 could be used to accurately predict diabetic nephropathy. Diabetes mellitus has many complications. This study also included a series of complications of diabetes, such as diabetic retinopathy, diabetic ketoacidosis, diabetic foot infections and diabetic cardiopathy, while serum level of CASC2 was specifically reduced in diabetic nephropathy. CASC2 expression level decreased, while JNK1 phosphorylation level increased in mouse podocyte cells treated with high glucose. CASC2 overexpression inhibited apoptosis of podocyte cells and reduced phosphorylation level of JNK1. We conclude that long non-coding RNA CASC2 may improve diabetic nephropathy by inhibiting JNK pathway.

show abstract

“…Such cellular infiltrates have been reported in both animal experimental models and human renal biopsies(83). Of the various inflammatory cells involved, a prominent role can be attributed to macrophages, whose accumulation has been related to the severity of DN(84).The differentiation of monocytes into macrophages has been associated with an imbalance in the native HRs on these cells. H 1 R is up-regulated during differentiation, thus increasing the histaminergic response, while H 2 R is down-regulated(85).…”

mentioning

confidence: 98%

Histamine and diabetic nephropathy: an up-to-date overview

et al. 2019

View full text Add to dashboard Cite

The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.

show abstract

Immunoinflammation in Diabetic Nephropathy: Molecular Mechanisms and Therapeutic Options

Cited by 18 publications

References 120 publications

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway

Histamine and diabetic nephropathy: an up-to-date overview

Contact Info

Product

Resources

About