2022
DOI: 10.21203/rs.3.rs-2305929/v1
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Immunoinformatics design of novel peptide vaccines against Epstein-Barr virus with over 99% global population coverage: A Reverse Vaccinology approach

Abstract: Background Epstein-Barr virus is commonly known as human herpes virus 4; an oncovirus belonging to the herpes virus family. The pathogen is extremely ubiquitous and infects more than 90% of population once in a lifetime. Methods The current study has employed a computational pipeline to develop a multiepitope vaccine design by targeting the most antigenic glycoproteins of the virus. The proteins were separately processed to retrieve B-cell and T-cell epitopes. The most suitable epitopes were scrutinized to d… Show more

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