Immunolocalization of gelatinase-A (matrix metalloproteinase-2) in damaged human temporomandibular joint discs

Marchetti, Carla; Cornaglia, I; Casasco, Andrea; Bernasconi, G; Baciliero, Ugo; Stetler-Stevenson, William G.

doi:10.1016/s0003-9969(98)00107-1

Cited by 15 publications

(11 citation statements)

References 20 publications

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“…Indeed, chondrocytes are highly sensitive to 3-D microenvironment and exhibit changes in differentiation status in response to environmental cues (Lemare et al, 1988;Goldring, 2004a;Goldring, 2004b), with expression of cartilage ECM elements likely reflecting regional variation due to differential loading patterns in distinct joint regions (Bayliss et al, 1983;Nakano and Scott, 1989;Mow et al, 1990;Hamrick, 1999;Tanaka et al, 2000). In this regard, it is interesting that collagen-and proteoglycan-degrading proteinases have been reported in TMJ tissues and synovial fluids (Kiyoshima et al, 1993;Kiyoshima et al, 1994;Marchetti et al, 1999;Puzas et al, 2001;Srinivas et al, 2001).…”

Section: Adaptive Plasticity and Degradation In Masticatory Tissuesmentioning

confidence: 99%

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Ravosa

Kunwar

Stock

et al. 2007

Journal of Experimental Biology

151

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SUMMARY Excessive, repetitive and altered loading have been implicated in the initiation of a series of soft- and hard-tissue responses or `functional adaptations' of masticatory and locomotor elements. Such adaptive plasticity in tissue types appears designed to maintain a sufficient safety factor, and thus the integrity of given element or system, for a predominant loading environment(s). Employing a mammalian species for which considerable in vivo data on masticatory behaviors are available, genetically similar domestic white rabbits were raised on diets of different mechanical properties so as to develop an experimental model of joint function in a normal range of physiological loads. These integrative experiments are used to unravel the dynamic inter-relationships among mechanical loading, tissue adaptive plasticity, norms of reaction and performance in two cranial joint systems:the mandibular symphysis and temporomandibular joint (TMJ). Here, we argue that a critical component of current and future research on adaptive plasticity in the skull, and especially cranial joints, should employ a multifaceted characterization of a functional system, one that incorporates data on myriad tissues so as to evaluate the role of altered load versus differential tissue response on the anatomical, cellular and molecular processes that contribute to the strength of such composite structures. Our study also suggests that the short-term duration of earlier analyses of cranial joint tissues may offer a limited notion of the complex process of developmental plasticity, especially as it relates to the effects of long-term variation in mechanical loads, when a joint is increasingly characterized by adaptive and degradative changes in tissue structure and composition. Indeed, it is likely that a component of the adaptive increases in rabbit TMJ and symphyseal proportions and biomineralization represent a compensatory mechanism to cartilage degradation that serves to maintain the overall functional integrity of each joint system. Therefore, while variation in cranial joint anatomy and performance among sister taxa is, in part, an epiphenomenon of interspecific differences in diet-induced masticatory stresses characterizing the individual ontogenies of the members of a species,this behavioral signal may be increasingly mitigated in over-loaded and perhaps older organisms by the interplay between adaptive and degradative tissue responses.

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Section: Adaptive Plasticity and Degradation In Masticatory Tissuesmentioning

confidence: 99%

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Ravosa

Kunwar

Stock

et al. 2007

Journal of Experimental Biology

151

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“…Table 2. Studies that fit all inclusion criteria, but were published more than 10 years ago [18][19][20][21][22][23][24][25][26][27].…”

Section: General Outcomesmentioning

confidence: 99%

Matrix Metalloproteinases and Temporomandibular Joint Disorder: A Review of the Literature

et al. 2019

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Temporomandibular disorders (TMD) are progressive degenerative disorders that affect the components of the temporomandibular joint (TMJ), characterized by pain and limitations in function. Matrix metalloproteinases (MMP) are enzymes involved in physiological breakdown of tissue that can have a pathological effect from an increase in activity during inflammation. A PubMed search of the current literature (within the past 10 years) was conducted to identify human studies involving matrix metalloproteinases activity in TMJ components of patients with TMD. Two separate searches results in 34 studies, six of which met inclusion criteria. Immunohistochemistry and gene analysis were used to evaluate MMP expression in the study groups. This review showed the strongest evidence for involvement of MMP-1, MMP-2, and MMP-9 in TMD; however, limitations included low sample sizes and a lack of recent clinical studies. Future research with more definitive conclusions could allow for additional pharmaceutical targets in MMP when treating patients with temporomandibular disorders.

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“…This evidence supports the presence of 6 of the 28 known MMPs (ie, MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-13) in fluid or tissue samples obtained from diseased human TMJ (Fig 4). 52,[59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] Production of MMPs by resident cell populations, especially the osteoclast, can be induced by TNF-␣, IL-6, and RANKL. 60,62,64,68,77 Some MMPs are secreted by cells in inactive or latent forms and may subsequently be activated by other enzymes or by oxidation reactions initiated by free radicals.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Pathophysiology and Pharmacologic Control of Osseous Mandibular Condylar Resorption

Gunson¹,

Arnett²,

Milam³

2012

Journal of Oral and Maxillofacial Surgery

133

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Immunolocalization of gelatinase-A (matrix metalloproteinase-2) in damaged human temporomandibular joint discs

Cited by 15 publications

References 20 publications

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Matrix Metalloproteinases and Temporomandibular Joint Disorder: A Review of the Literature

Pathophysiology and Pharmacologic Control of Osseous Mandibular Condylar Resorption

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