Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice

Fowles, Jefferson; Fairbrother, Anne; Baecher-Steppan, L; Kerkvliet, Nancy I.

doi:10.1016/0300-483x(94)90052-3

Cited by 250 publications

(134 citation statements)

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“…Hydroxylated BDEs are structurally very similar to thyroid hormones, and have been shown to displace thyroid hormones from the thyroxin plasma transporter transthyretin (TTR) (Meerts et al 2000). PBDEs have also been reported to decrease levels of total and free T 4 in adult animals (Fowles et al 1994;Hallgren et al 2001), and following developmental exposure (discussed below). Various PBDEs have been reported to induce mixed-type monoxygenase in vivo.…”

Section: Toxicity Of Pbdesmentioning

confidence: 99%

“…Fowles et al (1994) first reported that adult mice exposed for two weeks to DE-71 had decreased levels of circulating T 4 . Exposure of adult mice and rats to BDE-47 or to the pentaBDE mixture Bromkal 70-5DE, decreased serum total and free T 4 levels, without altering thyrotropin (TSH) levels (Hallgren et al 2001;Hallgren and Darnerud, 2002).…”

Section: Effects On Thyroid Hormonesmentioning

confidence: 99%

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Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

2007

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Section: Toxicity Of Pbdesmentioning

confidence: 99%

Section: Effects On Thyroid Hormonesmentioning

confidence: 99%

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

2007

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“…Semen as a non-invasive matrix can be used to measure the human burden of these POPs. Several reports on laboratory animals showed that PBDEs might affect male reproductive health by interfering with the sex-hormone functions (Fowles et al, 1994;Zhou et al, 2002). However, whether PBDEs are present in human semen and whether semen can be used as matrix to measure the human burden of PBDEs have not been explored.…”

Section: Introductionmentioning

confidence: 99%

Determination of polybrominated diphenyl ethers in human semen

Liu

Zhao

Zhu

et al. 2012

Environment International

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Some persistent organic pollutants (POPs) have been found in human semen but until this point it was unclear whether polybrominated diphenyl ethers (PBDEs) could be detected in human semen. In this study, PBDEs were found for the first time in human semen samples (n = 101) from Taizhou, China. The concentrations of total PBDEs (∑PBDEs) varied from 15.8 to 86.8 pg/g ww (median = 31.3 pg/g ww) and 53.2 to 121 pg/g ww (median = 72.3 pg/g ww) in semen and blood samples, respectively. The ∑PBDE level in semen was about two times lower than in human blood, which was different in the distribution in the two matrices from other POPs. A correlation of ∑PBDE concentration was found between paired semen and in blood. The results suggest that semen could be used to detect PBDE burden in human body as a non-invasive matrix. In addition, the levels of BDE-209 and BDE-153, especially the latter, were much higher in blood than in semen, while the levels of BDE-28, BDE-47 and BDE-99 were comparable in the two matrices, suggesting that low brominated congeners could be more easily transferred to semen than high brominated congeners. Considering different toxicities among the PBDE congeners, it might be more significant to measure PBDEs in semen than in blood for evaluating male reproduction risks of PBDEs.

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“…Since PBDEs are somewhat structurally similar to thyroid hormones such as thyroxine (T4), it was speculated that PBDEs might mimic thyroid hormones and disrupt thyroid homeostasis. Several studies indicate that exposure to PBDEs can decrease the circulating levels of T4 in laboratory animals (Fowles et al, 1994;Zhou et al, 2002) and can cause permanent neurological effects similar to those associated with thyroid hormone deficiencies (Eriksson et al, 2001;Viberg et al, 2004). In addition, several PBDEs possess weak estrogenic/antiestrogenic activities (Meerts et al, 2001).…”

mentioning

confidence: 99%

Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality

Akutsu

Takatori

Nozawa

et al. 2008

Bull Environ Contam Toxicol

128

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Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants; currently, they are identified as ubiquitous environmental contaminants. Several studies indicate that PBDEs might affect male fertility. We present the results of a pilot study on the relationship between human serum PBDEs and sperm quality. The PBDE levels in Japan are comparable to those found in European countries. Strong inverse correlations were observed between the serum concentration of 2,2′,4,4′,5,5′-hexabromodiphenyl ether and sperm concentration (r = -0.841, p = 0.002) and testis size (r = -0.764, p = 0.01). Extensive studies on the relationship between PBDEs and sperm quality are required.Keywords: polybrominated diphenyl ethers; flame retardants; human serum; sperm. * Correspondence to: Kazuhiko Akutsu Phone: +81-6-6972-1321 FAX: +81-6-6972-2393 E-mail: akutu@iph.pref.osaka. jp 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in the production of common consumer products such as electronics, furniture, and textiles. PBDEs are currently recognized as environmental pollutants of global concern because their levels in the environment and in humans have increased markedly over the past several decades (Meironyté et al., 1999;Ikonomou et al., 2002;Akutsu et al., 2003). Since PBDEs are somewhat structurally similar to thyroid hormones such as thyroxine (T4), it was speculated that PBDEs might mimic thyroid hormones and disrupt thyroid homeostasis. Several studies indicate that exposure to PBDEs can decrease the circulating levels of T4 in laboratory animals (Fowles et al., 1994;Zhou et al., 2002) and can cause permanent neurological effects similar to those associated with thyroid hormone deficiencies (Eriksson et al., 2001;Viberg et al., 2004). In addition, several PBDEs possess weak estrogenic/antiestrogenic activities (Meerts et al., 2001). The proliferation and differentiation of Sertoli cells and sperm production are regulated by thyroid and sex hormones. Thus, PBDEs might affect male reproductive health by interfering with the thyroid-and sex-hormone functions. Kuriyama et al. (2005) have reported that developmental exposure to a single low dose (60 µg/kg body weight) of 2,2′,4,4′,5-pentabromodiphenyl ether (PeBDE-99) decreased the sperm count in male Wistar rats. However, no previous studies have examined the relationship between human PBDE levels and sperm quality.We participated in an international project examining the sperm quality of fertile males and found that the sperm concentration of Japanese males was lower than that of European males (Iwamoto et al., 2006). The examination of sperm quality and an estimation of the concentration of chemicals in the serum would be required to reveal the correlation between chemical exposure and the sperm quality in Japanese males. The aim of this pilot study was to measure PBDEs...

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Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice

Cited by 250 publications

References 17 publications

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

Determination of polybrominated diphenyl ethers in human semen

Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality

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