Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality

Akutsu, Kazuhiko; Takatori, Satoshi; Nozawa, Shiari; Yoshiike, Miki; Nakazawa, Hiroyuki; Hayakawa, Kazuichi; Makino, Tsunehisa; Iwamoto, Teruaki

doi:10.1007/s00128-008-9370-4

Cited by 128 publications

(75 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Effects of PBDEs in animal models include endocrine disruption, neurodevelopmental and behavioural effects, hepatic abnormalities, and possibly cancer (McDonald, 2002;Birnbaum and Staskal, 2004;Darnerud, 2008). Although little human epidemiology has yet been done, early studies suggest effects on male reproductive hormones (Meeker et al, 2009) and fertility (Akutsu et al, 2008b), thyroid hormone homeostasis (Turyk et al, 2008), cryptorchidism (Main et al, 2007), and lower birth weight and length (Chao et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

PBDE exposure from food in Ireland: optimising data exploitation in probabilistic exposure modelling

Trudel

Tlustos

Goetz

et al. 2010

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants added to plastics, polyurethane foam, electronics, textiles, and other products. These products release PBDEs into the indoor and outdoor environment, thus causing human exposure through food and dust. This study models PBDE dose distributions from ingestion of food for Irish adults on congener basis by using two probabilistic and one semi-deterministic method. One of the probabilistic methods was newly developed and is based on summary statistics of food consumption combined with a model generating realistic daily energy supply from food. Median (intermediate) doses of total PBDEs are in the range of 0.4-0.6 ng/kg bw /day for Irish adults. The 97.5th percentiles of total PBDE doses lie in a range of 1.7-2.2 ng/kg bw /day, which is comparable to doses derived for Belgian and Dutch adults. BDE-47 and BDE-99 were identified as the congeners contributing most to estimated intakes, accounting for more than half of the total doses. The most influential food groups contributing to this intake are lean fish and salmon which together account for about 22-25% of the total doses.

show abstract

Section: Introductionmentioning

confidence: 99%

PBDE exposure from food in Ireland: optimising data exploitation in probabilistic exposure modelling

Trudel

Tlustos

Goetz

et al. 2010

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

show abstract

“…With regard to toxicity for male reproduction, Main et al (2007) found significantly higher ΣPBDEs concentrations in the breast milk of nursing mothers of boys with cryptorchidism than in the nursing mothers of boys not affected by the disorder, and they also found that ΣPBDEs in breast milk associates positively with the serum of luteinizing hormone. Serum BDE-153 in male adults (n = 10) is inversely correlated with semen quality and testes size (Akutsu et al, 2008). In an American study in Massachusetts (Meeker et al, 2009), a study recruited 24 nonsmoking men age 18-54 to investigate house dust PBDE concentrations.…”

Section: Pbdes and Reproductionmentioning

confidence: 99%

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Chao

Huang

Hsu

et al. 2014

Aerosol Air Qual. Res.

View full text Add to dashboard Cite

The goal of this report is to evaluate brominated persistent organic pollutants (POPs) in the indoor air and dust to further assess their health effects on thyroid hormones and neurodevelopment in infants, toddlers, and young children. This category of brominated POPs includes polybrmonated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), polybrominated biphenyls (PBBs), and polybrominated dibenzo-p-dioxins (PBDD/DFs). These organobromines are lipophilic compounds which resist physical and chemical degradation in the environment and biota, and so easily bioaccumulate in adipose tissue. Brominated POPs, particularly in brominated fire retardants (BFRs) such as PBDEs, HBCDs, and PBBs, are ubiquitous in indoor environments due to their inadvertent release from certain consumer products. Some of these organobromines have been recognized in some in-vitro and in-vivo studies to be neurotoxins and disrupt thyroid hormones, although the evidence from actual epidemiological studies is contradicted and inconsistent, especially for infants, toddlers, and young children, who are particularly vulnerable to these substances as they spend most of their time in the home. This report focuses on exposure to PBDEs, HBCDs, PBBs, and PBDD/DFs in the indoor dust and on the indoor aerosol, to explore their association with human health, particularly the disruption of thyroid hormones and neurodevelopment in early childhood.

show abstract

“…A summary of published epidemiological investigations into the effects of PBDEs on semen quality or sex hormones is listed in Table 1. In a pilot study on 45 young Japanese males, a simple linear regression model was used to show a strong inverse correlation between the concentration of 2,2′,4,4′,5,5′-hexabromodiphenyl ether (BDE-153) in sperm and total sperm concentration (r = -0.841, p = .002) and testis size (r = -0.764, p = .01) (Akutsu et al, 2008). A cross-sectional study on American men reported a robust inverse relationship between PBDE levels in house dust and serum concentrations of luteinizing hormone (LH) and FSH, and a positive association between PBDEs and sex hormone-binding globulin (SHBG) (Meeker et al, 2009).…”

Section: Polybrominated Diphenyl Ethersmentioning

confidence: 99%

Airborne Persistent Organic Pollutants and Male Reproductive Health

Hsu

Guo

Smith³

et al. 2014

Aerosol Air Qual. Res.

View full text Add to dashboard Cite

Persistent organic pollutants (POPs) are chemicals that persist in the environment, bioaccumulate through the food chain, and exhibit toxic effects that threaten the health of humans and animals alike. The potential influence of POPrelated air pollution on male reproductive outcomes has attracted increasing interest in the scientific community and among policymakers and the public. Therefore, epidemiological studies on fertility should examine the impact of chronic exposure to POPs via inhalation. The objective of this review is to present and discuss the available evidence linking the exposure to airborne POPs to male reproductive health problems. This study focuses on the air concentrations, biomarkers, and potential effects on the male reproductive health of two classes of POPs: the industrial polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Although the association between atmospheric pollutants and male reproductive health has been extensively investigated, particularly in relation to semen quality and endocrine outcomes, the molecular mechanisms of action, the adverse effects, and the dose-response relationships for many of these chemicals remain poorly understood. No systematic screening of common chemicals for negative endocrine effects is currently underway, and many questions remain regarding the impact on male reproductive health of exposures to these POPs. This review presents the air concentrations, biomarkers, and adverse male reproductive effects of PCBs and PBDEs pollutants. Given the dearth of information on this topic in the literature, studies are clearly needed to assess how pre-and post-natal exposure to airborne PCBs and PBDEs affects the male reproductive system. Future studies must also identify aerosols and airborne POPs that have a significant impact on male reproductive health and the pathways responsible for those effects.

show abstract

Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality

Cited by 128 publications

References 13 publications

PBDE exposure from food in Ireland: optimising data exploitation in probabilistic exposure modelling

PBDE exposure from food in Ireland: optimising data exploitation in probabilistic exposure modelling

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

Airborne Persistent Organic Pollutants and Male Reproductive Health

Contact Info

Product

Resources

About