Immunologic aspects of Graves' and Hashimoto's diseases

Kidd, Arthur; Okita, Nobumitsu; Row, Vas V.; Volpé, Robert

doi:10.1016/0026-0495(80)90102-x

Cited by 88 publications

(23 citation statements)

References 97 publications

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“…In a group of patients with exophthalmos increased levels of serum T g were found only in thyrotoxic patients and were totally unrelated to the severity of the eye manifestation (40). It has been proposed that the thyroid disorder and exophthalmos constitute different disease entities (40, 78) with a mutual underlying disturbance in immune regulation, and close gentic links (61). In favour of this hypothesis are the above-mentioned findings of a non-uniform association with hyperthyrodism and the demonstration of delayed type hypersensitivity against eye muscle extract in patients with exophthalmos (78).…”

Section: Serum Thyroglobulin Its Autoantibodies and Thyroid-stimulamentioning

confidence: 99%

“…Graves' disease is assumed to be an autoimmune disease caused by overproduction of TSIg (61). T h e primary defect in the immune system leading to this overproduction is not yet known, but both humoral (2, 61) and cell-mediated (8, 77,121) immune mechanisms seem to be involved, as recently reviewed (61,125), and possibly also an invading organism in a genetically predisposed individual is needed ( 125) to start this autoimmune reaction (reviewed in 121).…”

Section: Serum Thyroglobulin Its Autoantibodies and Thyroid-stimulamentioning

confidence: 99%

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Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Feldt‐Rasmussen

1983

Allergy

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Section: Serum Thyroglobulin Its Autoantibodies and Thyroid-stimulamentioning

confidence: 99%

Section: Serum Thyroglobulin Its Autoantibodies and Thyroid-stimulamentioning

confidence: 99%

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Feldt‐Rasmussen

1983

Allergy

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“…Another as pect of the similarity between the two dis eases is the fact that there is an association with the major histocompatibility antigens HLA-D3, BW35 and A3. Some of these anti gens have been found in Graves' disease [16], chronic lymphocytic thyroiditis [17] and mitral valve prolapse [18].…”

Section: Commentmentioning

confidence: 99%

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Brauman¹,

Rosenberg²,

Gilboa³

et al. 1988

Cardiology

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An increased prevalence of mitral valve prolapse has been found in Graves’ disease and a common autoimmune etiology has been suggested for both disorders. We investigated the prevalence of mitral valve prolapse in 87 patients with autoimmune chronic lymphocytic thyroiditis, 50 patients with nongoitrous hypothyroidism and 111 healthy control subjects. Mitral valve prolapse was found in 16.09% of patients with chronic lymphocytic thyroiditis compared to 6 and 5.4% in nongoitrous hypothyroidism and normal controls, respectively. The result is statistically significant, p < 0.02, and confirms that the prevalence of mitral valve prolapse is significantly increased in patients with autoimmune disorders of the thyroid gland, when compared to normals and nonautoimmune conditions.

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“…Several recent reviews are available on this subject [1,2]. In the present report, early studies are briefly reviewed, and emphasis is given to the most recent findings on the nature of the antigen, assay procedures and clinical significance of thyroid-stimulating immunoglobulins.…”

Section: Introductionmentioning

confidence: 99%

Thyroid-Stimulating Immunoglobulins

Pinchera¹,

Fenzi²,

Macchia³

et al. 1982

Horm Res

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The presence of thyroid-stimulating immunoglobulins in patients with Graves’ disease is well established. Considerable evidence has accumulated that these immunoglobulins are antibodies to a thyroid plasma membrane antigen whose precise nature remains to be identified. The question whether the antigen is related to the TSH receptor is still debated. The causative role of thyroid-stimulating immunoglobulins in the hyperthyroidism of Graves’ disease is widely recognized. The use of human specific stimulation assays has circumvented the objection of the relatively low frequency of long-acting-thyroid-stimulator-(LATS)-positive patients. Individual variations in the thyroid response may account for the lack of correlation between the levels of thyroid-stimulating immunoglobulins and most parameters of thyroid function. In this respect, the interference of nonstimulatory thyroid antibodies and of other autoimmune mechanisms may be of importance. An important clinical implication of thyroid-stimulating immunoglobulin determinations is their value in predicting the relapse of hyperthyroidism in treated patients. This clinical application has been so far limited by the technical difficulties of the assays. This emphasizes the need for a simple and reliable test, which can be used for routine measurements of thyroid-stimulating immunoglobulins.

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Immunologic aspects of Graves' and Hashimoto's diseases

Cited by 88 publications

References 97 publications

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Thyroid-Stimulating Immunoglobulins

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