Immunologic studies in Burkitt's lymphoma

Ziegler, John L.; Cohen, Martin H.; Morrow, Richard H.; Kyalwazi, S. K.; Carbone, Paul P.

doi:10.1002/1097-0142(197003)25:3<734::aid-cncr2820250335>3.0.co;2-1

Cited by 43 publications

(3 citation statements)

References 13 publications

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“…(Henle & Henle, 1966;O'Conor, 1961), the unusually high cure rate after relatively small doses of drugs (Ziegler et al 1967;Burkitt, 1967), and the occurrence of spontaneous cures (D. P. Burkitt, personal communication), all suggest that the disease is strongly influenced by the patient's immune reaction. Some have postulated that the difference between B.1.…”

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confidence: 99%

The Immunodepressive Effect of a Murine Plasmodium and its Interaction with Murine Oncogenic Viruses

Salaman

Wedderburn

Bruce-Chwatt

1969

Journal of General Microbiology

109

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SUMMARYPZasmodium berghei yoelii (p.b.y.) was found to cause an acute selflimiting infection in Balb/c mice, lasting for 14 to 18 days. A sharp fall in the primary response to sheep erythrocytes, as measured by the number of haemolytic plaque-forming cells in the spleen, and by the appearance of antibodies in the serum, coincided with high levels of parasitaemia between the 8th and I Ith days of p.b.y. infection. A secondary response to sheep erythrocytes was similarly affected when animals were infected with p. b.y. g days before the second antigen injection. Mice were resistant to reinfection with p.b.y., which produced either transient or no parasitaemia, and no immunodepression.In mice carrying an immunodepressive leukaemogenic virus by vertical transmission, infection with a similar dose of p.b.y. was usually fatal.Murine sarcoma virus (Harvey : m.s.v./H) produces tumours and splenomegaly in newborn mice but very rarely in adults. When injected into adult Balb/c mice at the height of p.b.y. infection, m.s.v./H produced a high incidence of splenomegaly 4 weeks later, although the splenomegaly induced by the plasmodium alone had by then subsided.These results are discussed in relation to Burkitt's (1969) hypothesis of a causal connection between chronic malarial infection and development of Burkitt lymphoma in children.

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confidence: 99%

The Immunodepressive Effect of a Murine Plasmodium and its Interaction with Murine Oncogenic Viruses

Salaman

Wedderburn

Bruce-Chwatt

1969

Journal of General Microbiology

109

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“…There is considerable interest in the role of cell-mediated immunity in Burkitt's lymphoma (Zeigler et al, 1970;Klein, 1971;Stjernsward et al, 1970;Golub et al, 1972), an attractive hypothesis being that chronic heavy malarial infestation interferes with the host defences against the lymphoproliferative action of EB virus (Kafuko and Burkitt, 1970;Harris, 1970;Burkitt, 1970;McGregor, 1972). In the case of other African tumours, information is less complete but the differences in the pattern of malignant disease between Western countries and Africa south of the Sahara and, even over quite short distances, within Africa itself, suggest that environmental factors are involved in their aetiology (Burkitt, 1973).…”

Section: Discussionmentioning

confidence: 99%

A bank of frozen peripheral blood lymphocytes for In vitro immunological studies on east African cancer patients

Steel

Levin²,

Tsu³

et al. 1974

Intl Journal of Cancer

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A bank of peripheral blood lymphocytes, frozen in liquid nitrogen, has been established from East African cancer patients and from control donors including healthy individuals and patients with nonmalignant disorders. The techniques of collection, lymphocyte separation and cell freezing are simple enough to have been applied successfully in an isoluted mission hospital. I n the first year of operation samples have been stored from over 400 individuals. On recovery, the cells have high viability, will respond to PHA in culture, are suitable for determination of HL-A phenotype and react with sheep red blood cells in the spontaneous rosette test. It is predicted that lymphocyte banks of this type will have a useful place in the study o f immunological factors in cancer, particularly in developing countries.

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“…Despite this, until the advent of the HIV epidemic and application of organ transplant technologies, which necessitated immunosuppressive therapy to prevent organ rejection, no clear evidence linking immunosuppression in individuals to the risk of BL was adduced [18]. Other provocative questions went unanswered.…”

Section: Burkitt Lymphoma: Beyond Discoveriesmentioning

confidence: 99%

Burkitt Lymphoma: beyond discoveries

Mbulaiteye

2013

Infect Agents Cancer

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First described in 1958 in Uganda, Burkitt lymphoma (BL) attracted interest worldwide following reports of its uneven geographic distribution and rapidly fatal clinical course. Both suggested infectious etiology and curability. Seminal discoveries followed in quick succession. Viral etiology – due to Epstein-Barr virus (EBV) – was confirmed. Chromosomal translocations, involving cellular MYC, a protooncogene, were discovered, shown to be a hallmark of BL, and central to the genetic basis of cancer. Cure of BL using combination chemotherapy was demonstrated. Unfortunately, civil disturbance in Africa disrupted BL research and blunted its impact on education and oncology care in Africa. Important questions went unanswered. The risk of BL due to malaria or EBV was not quantified. Efforts to answer whether BL could be prevented – by preventing malaria or early EBV infection – were abandoned. The mechanism of malaria in BL is unknown. In Africa, BL remains mostly fatal and diagnosis is still made clinically. Unprecedented advances in molecular, genomics and proteomic technologies, promising to unlock mysteries of cancers, have re-awakened interest in BL. With return of stability to Africa, the unanswered questions about BL are re-attracting global interest. This interest now includes exploiting the knowledge gained about genetics, proteomics, and bioinformatics to enable the development of targeted less toxic treatment for BL; and simpler methods to diagnose BL with high accuracy and sensitivity. The articles in the Burkitt Lymphoma (BL): Beyond Discoveries in Infectious Agents and Cancer highlight BL as priority. Authors explore etiology, pathology, pathogenesis of BL, and whether knowledge gained in the studies of BL can catalyze sustainable cancer services in one of the world’s poorest served regions.

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Immunologic studies in Burkitt's lymphoma

Cited by 43 publications

References 13 publications

The Immunodepressive Effect of a Murine Plasmodium and its Interaction with Murine Oncogenic Viruses

The Immunodepressive Effect of a Murine Plasmodium and its Interaction with Murine Oncogenic Viruses

A bank of frozen peripheral blood lymphocytes for In vitro immunological studies on east African cancer patients

Burkitt Lymphoma: beyond discoveries

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