Immunologic Studies in Phenylketonuria

Passwell, J H; Gazit, Ephraim; Efter, T.; Modan, Michaela; Lilos, Pearl; Cohen, B. E.

doi:10.1111/j.1651-2227.1976.tb04952.x

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Our study confirms that immunoglobulin levels (primarily Ig and IgG levels) are altered in children with PKU (Passwell et al 1976;Giovannini et al 1988). Imbalances in immunoglobulin classes IgG and IgE are similar to imbalances found in some cases of common variable hypogammaglobulinaemia (Zwetchenbaum 1990) and have been described in atopic eczema (Reinhold et al 1988).…”

Section: Discussionsupporting

confidence: 88%

“…Little is known about the immunological features of children with PKU. Although immunological indices of these children were previously considered to be normal (Abba et al 1966), low IgG, IgM and Iga levels were subsequently described in 22 children aged 7 months to 21 years who had not been placed on diet therapy (Passwell et al 1976). These authors suggested a causal relationship between low levels of *Correspondence MS received 18.5.94 Accepted 4.7.94 immunoglobulins and reduced availability of tyrosine, an amino acid highly represented in antibodies.…”

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confidence: 99%

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PKU‐related dysgammaglobulinaemia: The effect of diet therapy on IgE and allergic sensitization

Riva

Fiocchi

Agostoni

et al. 1994

J of Inher Metab Disea

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The effect of diet on the development of immunoallergic signs and symptoms in children with phenylketonuria (PKU) was evaluated. Immunological indices of 58 children with PKU treated with diets were compared to the immunological indices of 58 healthy (non-PKU) children. In the PKU group, 39 children had been placed on diet therapy within the first month of life; 19 children had been placed on diet therapy after 6 months of age. Total circulating lymphocytes; CD3+, CD4+, CD8+ circulating lymphocytes; and serum IgA, IgM, IgG and total IgE levels were measured for each child. Skin prick tests were performed for common inhalant and food allergens. Every 3 months over the 2-year period of this study, the signs and symptoms of eczema, allergic rhinitis and asthma were recorded. The PKU group had lower IgG levels (p = 0.004) and higher total IgE levels (p = 0.0001) than the control group. Significantly lower IgE levels were found in children started on diet therapy within the first month of life compared with those started on diet therapy after 6 months of age (p = 0.0001). Allergic sensitization was significantly more frequent in the PKU group (24/58 vs 13/58, z = 2.00, p < 0.05), but no significant difference in the incidence of eczema and allergic rhinitis was found. Asthma was less frequent in the PKU group than in the control group (5/58 vs 14/58, z = 2.09, p < 0.05). Thus, diet appeared to prevent the development of immunoallergic signs and symptoms.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

PKU‐related dysgammaglobulinaemia: The effect of diet therapy on IgE and allergic sensitization

Riva

Fiocchi

Agostoni

et al. 1994

J of Inher Metab Disea

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“…El unico trabajo publicado muestra que no existe altera- cifras corresponden al promedio geome'trico, entre cion de la rcspuesta cutanea de hipersensibilidad retardada, del niimero de linfocitos T y de la capacidad proliferativa de linfocitos frente a PHA 17 . Sin embargo, los invcstigadores no realizaron una curva dosis-respuesta e incluso no senalan la concentracion dc mitogeno ulilizado 17 . En nuestro estudio realizamos una curva dosis-respuesta frente a PHA en cada pacicnte, antes y despue"s de la suplementacion con /inc.…”

Section: Comentariounclassified

Respuesta inmune celular como indicador biológico de deficiencia de zinc: en pacientes con fenilquetonuria

Z²,

G³

et al. 1993

Rev. chil. pediatr.

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Cell-mediated inmune response as a biological indicator of zinc deficiency: phenylketonuria as a study modelContradictory information exists in relation to zinc nutritional status in phenylketonuria. The objetive of this study was to confirm that there it is indirect evidence of zinc deficiency in patients with phenylketonuria as measured by the effect of zinc supplementation on cell-mediated inmune response. Delayed cutaneous hyper sensitivity readion and lymphopfoliferative response to phyohemagalutinin was determined in eight phenylketonuric children under specific nutritional management (low phenylalanine diet) before and after zinc acetate supplementation. Two of eight patients had a positive cutaneous response at admission and six became positive after zinc supplementation. This difference was statistically significant (p < 0.05 Mac Nemar test). Lymphoproliferative response to PHA was also significantly increased at the end of zinc supplementation, from a stimulation Index at PHA 5pg/culture 52.4 (I 1 -246] to 3 ] 5 (263-376) [mean, 1 SD range, p < 0.05 T-par). The improvement of cell mediated inmune response after zinc supplementation, suggests that zinc deficiency is present in phenylketonuric patients treated with low phenylalanine diets.[Key word it cell-mediated inmune response, zinc nutritional status, phenylketonuria, phenylalanine.) Arevato M. y cols. Revisla Chilena de PediatrlaMayo-Junio 1993

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Immunologic Studies in Phenylketonuria

Cited by 2 publications

References 15 publications

PKU‐related dysgammaglobulinaemia: The effect of diet therapy on IgE and allergic sensitization

PKU‐related dysgammaglobulinaemia: The effect of diet therapy on IgE and allergic sensitization

Respuesta inmune celular como indicador biológico de deficiencia de zinc: en pacientes con fenilquetonuria

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