Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress

Simão, A.N.C.; Lozovoy, M.A.B.; Simão, T.N.C.; Venturini, D.; Barbosa, D.S.; Dichi, J.B.; Matsuo, T.; Cecchini, Rúbens; Dichi, I.

doi:10.1590/s0100-879x2011000700015

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Simão et al, in a case-control study, identified lower concentrations of nitrite/nitrate in the MetS group, reflecting lower concentrations of • NO [50]. In opposition to these observations, Ueyama et al [51] showed that the concentrations of nitrite/nitrate increased when the number of the MetS diagnostic criteria was progressively augmented in humans.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the Myeloperoxidase/Hydrogen Peroxide Axis

Fonseca

Nunes-Souza

Guedes

et al. 2014

Oxidative Medicine and Cellular Longevity

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The present study evaluated the cardiometabolic and redox balance profiles in patients with Metabolic Syndrome compared to apparently healthy individuals, and the participation of the myeloperoxidase/hydrogen peroxide axis in systemic lipid peroxidation. Twenty-four patients with Metabolic Syndrome and eighteen controls underwent a full clinical assessment. Venous blood samples were collected for general biochemical dosages, as well as for the oxidative stress analyses (superoxide dismutase, catalase, and arginase activities; and lipid peroxidation, myeloperoxidase activity, nitrite, and hydrogen peroxide concentrations in plasma). Arterial stiffness was assessed by radial artery applanation tonometry. Plasma lipid peroxidation, erythrocyte superoxide dismutase activity, myeloperoxidase activity, and hydrogen peroxide concentrations were shown to be increased in Metabolic Syndrome patients, without significant differences for the other enzymes, plasma nitrite concentrations, and arterial stiffness. Linear regression analysis revealed a positive and significant correlation between lipid peroxidation and myeloperoxidase and also between this enzyme and hydrogen peroxide. In contrast, such correlation was not observed between lipid peroxidation and hydrogen peroxide. In summary, Metabolic Syndrome patients exhibited evident systemic redox imbalance compared to controls, with the possible participation of the myeloperoxidase/hydrogen peroxide axis as a contributor in lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the Myeloperoxidase/Hydrogen Peroxide Axis

Fonseca

Nunes-Souza

Guedes

et al. 2014

Oxidative Medicine and Cellular Longevity

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show abstract

“…Although endothelial dysfunction has been considered an important issue in patients with the MetS, results of studies on serum NOx levels in these patients have been contradictory ( 56 – 58 ) . The majority of the studies support the hypothesis that even in low-grade inflammatory processes, such as in the MetS, NO is consumed in a reaction with superoxide anion yielding a strong oxidant species, ONOO − , which in turn accelerates the lipid peroxidation reaction ( 59 ) .…”

Section: Discussionmentioning

confidence: 99%

Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

et al. 2018

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Beneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects of Bifidobacterium lactis HN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 and P=0·03, respectively), hydroperoxides (P=0·02 and P=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx, P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion, B. lactis HN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

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“…Inducible NOS www.nature.com/aps Pârvu AE et al Acta Pharmacologica Sinica npg (NOS2/iNOS) is expressed by various cells, such as macrophages and fibroblasts, in response to inflammatory stimuli, and it produces large amounts of NO. Since large amounts of NO are toxic, NO has been implicated in the pathophysiology of several inflammatory conditions [9][10][11][12] . In such diseases, under conditions of high and sustained NO production, reactive nitrogen oxide species (RNS) (such as nitrogen dioxide, NO 2 ; dinitrogen trioxide, N 2 O 3 ; and peroxynitrite, ONOO -) are formed by reactions with reactive oxygen species (ROS), and may result in nitrosative or oxidative stress [13,14] .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis

et al. 2012

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Aim: To evaluate the effectiveness of subantimicrobial-dose doxycycline (SDD) as an adjunct to scaling and root planing (SrP) treatment against the nitrosative stress of moderate to advanced chronic periodontitis. Methods: Adults with untreated chronic periodontitis (n=174) were randomly administered SrP+SDD (n=87) (20 mg of doxycycline twice daily) or SrP+placebo (n=87) treatment for 3 months. At baseline and after 3 months, the probing depths (PD), bleeding on probing (bOP) and clinical attachment level (CAl) were measured, and a gingivomucosal biopsy was collected to assay the induction of nitric oxide synthase (inOS) and 3-nitrotyrosine (3nT), and blood was collected to assay for total nitrites and nitrates (nO x ) and 3nT. Results: Compared to baseline, at the completion of treatment, significant decreases in the levels of tissue inOS and 3nT and serum nO x and 3nT were observed in both groups. SrP+SDD yielded a greater reduction in the gingivomucosal and serum nitrosative stress markers than did SrP+placebo. PD, bOP, and CAl reduction were correlated with the nitrosative stress parameters. Conclusion: On a short-term basis, SDD therapy may be used as an adjunct to SrP treatment against nitrosative stress in moderate to advanced chronic periodontitis.

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Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress

Cited by 4 publications

References 12 publications

Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the Myeloperoxidase/Hydrogen Peroxide Axis

Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the Myeloperoxidase/Hydrogen Peroxide Axis

Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis

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