Immunological and Immunogenetic Aspects of Tumor Transplantation*

Hellström, Kjell; Möller, G

doi:10.1159/000385899

Cited by 34 publications

(30 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is unlikely that, in the environment of a CBA host, PFC of F1 origin would express only one of the parental H2 complexes. Complete loss of an entire H2 complex has been recorded in heterozygous tumor cells but only after exposure, through serial transplantation, to considerable immunological pressure against the complex (34). Furthermore, as will be evident in the second paper in this series (35), Fl-type PFC were detected in the environment of an irradiated CBA host.…”

Section: Transfer Of Thoracic Duct Cells From Mice Tolerant Of Sheep mentioning

confidence: 60%

“…In the case of CBA mice receiving C57BL cells, the possibility of antigenic exclusion cannot be entertained as complete loss of all H2 complexes has never been achieved, even in tumor cells (34). It might be suggested that FI or C57BL cells were either rejected or inhibited from differentiating in neonataily thymectomized CBA mice, thus accounting for the failure to detect PFC of donor origin.…”

Section: Transfer Of Thoracic Duct Cells From Mice Tolerant Of Sheep mentioning

confidence: 99%

See 1 more Smart Citation

Cell to Cell Interaction in the Immune Response

Miller

1968

The Journal of Experimental Medicine

527

130

View full text Add to dashboard Cite

An injection of viable thymus or thoracic duct lymphocytes was absolutely essential to enable a normal or near-normal 19S liemolysin-forming cell response in the spleens of neonatally thymectomized mice challenged with sheep erythrocytes. Syngeneic thymus lymphocytes were as effective as thoracic duct lymphocytes in this system and allogeneic or semiallogeneic cells could also reconstitute their hosts. No significant elevation of the response was achieved by giving either bone marrow cells, irradiated thymus or thoracic duct cells, thymus extracts or yeast. Spleen cells from reconstituted mice were exposed to anti-H2 sera directed against either the donor of the thymus or thoracic duct cells, or against the neonatally thymectomized host. Only isoantisera directed against the host could significantly reduce the number of hemolysin-forming cells present in the spleen cell suspensions. It is concluded that these antibody-forming cells are derived, not from the inoculated thymus or thoracic duct lymphocytes, but from the host. Thoracic duct cells from donors specifically immunologically tolerant of sheep erythrocytes had a markedly reduced restorative capacity in neonatally thymectomized recipients challenged with sheep erythrocytes. These results have suggested that there are cell types, in thymus or thoracic duct lymph, with capacities to react specifically with antigen and to induce the differentiation, to antibody-forming cells, of hemolysin-forming cell precursors derived from a separate cell line present in the neonatally thymectomized hosts.

show abstract

Section: Transfer Of Thoracic Duct Cells From Mice Tolerant Of Sheep mentioning

confidence: 60%

Section: Transfer Of Thoracic Duct Cells From Mice Tolerant Of Sheep mentioning

confidence: 99%

Cell to Cell Interaction in the Immune Response

Miller

1968

The Journal of Experimental Medicine

527

130

View full text Add to dashboard Cite

show abstract

“…Either the H-2-gene complex is associated with some physiologic self-recognition system, or T cells may be sensitized to "altered self" components. Allogeneic inhibition (13) has been excluded in both in vitro and in vivo studies using F, -, parent combinations (3,7) .…”

Section: Discussionmentioning

confidence: 99%

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.

Doherty¹,

Zinkernagel²

1975

The Journal of Experimental Medicine

283

View full text Add to dashboard Cite

Maximal cell-mediated lysis of targets infected with lymphocytic choriomeningitis virus occurs only within a H-2 compatible system. Syngeneic immune spleen cells are at least 100 times as effective as are allogeneic lymphocytes. Reciprocal restriction of cytotoxic T-cell activity has been shown to operative between H-2k, H-2d, and H-2b. Experiments with cogenic mice have localized the effect to the H-2 gene complex. Furthermore, the observation that lymphocytes from H-2a mice cause high specific 51Cr release from either H-2d virus-infected cells, indicates that identity at either the K or the D end of the H-2 gene complex is sufficient for this lytic interaction.

show abstract

“…Adoptive transfer of immunity with spleen cells was not attempted. 11 is well known, however, that this procedure cannot critically distinguish between cell-hound immunity and humoral immunity because of the high number of antibody-forming cells necessarily transferred (13).…”

Section: Tumor Immunity Following Reovirus Oncolysismentioning

confidence: 99%

“…Nonspecific transplantable mouse tumors are capable of pro gressive growth in many inbred and non-inbred mouse strains in spite of gross antigenic differences between tumor cells and host (13). Possible explanations for the survival of such tumors in anligenically disparate hosts may be their relatively non-immunogenic nature or a state of immunological unresponsiveness in the host.…”

mentioning

confidence: 99%

Antibody-Mediated Immunity to Transplantable Tumors Following Reovirus Oncolysis

Klein

1967

Pathobiology

View full text Add to dashboard Cite

Immunological and Immunogenetic Aspects of Tumor Transplantation*

Cited by 34 publications

References 0 publications

Cell to Cell Interaction in the Immune Response

Cell to Cell Interaction in the Immune Response

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.

Antibody-Mediated Immunity to Transplantable Tumors Following Reovirus Oncolysis

Contact Info

Product

Resources

About