Immunological Approach of the Challenges of the XXI Century in Celiac Disease

Samaşcă, Gabriel; Lupan, Iulia; Deleanu, Diana; Cristea, Victor; Makovický, Peter

doi:10.3109/08830185.2013.797414

Cited by 5 publications

(6 citation statements)

References 45 publications

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“…During the process of case-finding for adult CD, diagnosis depends on a well-constructed search plan in both typical and atypical forms [10]. Several methods of case-finding have been proposed, including several procedures.…”

Section: Discussionmentioning

confidence: 99%

Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Makovický¹,

Podlupszki²,

Makovický³

et al. 2016

IJCD

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Diagnosis of adult celiac disease is often a problematic part of clinical medicine. High risk groups for adult celiac disease deserve an intense search, even if atypical extra-intestinal symptoms suggest some other underlying cause. In part, diagnosis may occur over a long time period during adult years, and even then, could potentially remain undiagnosed until very late, even in very elderly stages of life. The objective of this work was to record our clinical experience with the diagnosis of adult forms of the celiac disease, in spite of their atypical presentations with extra-intestinal symptoms alone, and consider the role of serological testing for case-finding in these patients. We chose 9 adult patients with celiac disease diagnosed over a long period during an outpatient medical care by various physician specialists. Examination of autoantibodies for tissue transglutaminase, antiendomysium antibodies and autoantibodies against gliadin as well as cow's milk were done. To confirm positive autoantibodies as an indicator of adult celiac disease, samples of duodenal mucosa were taken and histopathologically examined.

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Section: Discussionmentioning

confidence: 99%

Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Makovický¹,

Podlupszki²,

Makovický³

et al. 2016

IJCD

Self Cite

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“…The alcohol soluble component of gluten is gliadin, which is considered to be the toxic component and is responsible for the pathogenesis of CD [4, 43]. …”

Section: Pathogenesismentioning

confidence: 99%

“…Most of the gliadin peptides are digested by pancreatic, gastric and intestinal enzymes except the peptides 33mer (P55-87) and 25mer (P31-55) and hence, these two active peptides are responsible for the activation of immune response in celiac intestine [43, 44]. The 33mer is deamidated by TG2 enzyme, then binds to HLA DQ2/8 and initiates Th1 cell response, whereas the P31-43 contained in the 25mer is not recognized by the T cells, but, it induces an innate immune response with production of IL-15 as the primary component [45].…”

Section: Pathogenesismentioning

confidence: 99%

Immunopathogenesis and therapeutic approaches in pediatric celiac disease

Agarwal

Kovilam

Zach

et al. 2016

Expert Review of Clinical Immunology

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Summary Celiac Disease is an autoimmune enteropathy with increasing incidence worldwide in both adults and children. It occurs as an inflammatory condition with destruction of the normal architecture of villi on consumption of gluten and related protein products found in wheat, barley and rye. However, the exact pathogenesis is not yet fully understood. A gluten-free diet remains the main modality of therapy to date. While some patients continue to have symptoms even on a gluten-free diet, adherence to this diet is also difficult, especially for the children. Hence, there is continued interest in novel methods of therapy and the current research focus is on the promising novel non-dietary modalities of treatment. Here, we critically reviewed the existing literature regarding the pathogenesis of celiac disease in children including the role of in-utero exposure leading to neonatal and infant sensitization and its application for the development of new therapeutic approaches for these patients.

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“…Several causative factors for explaining the mechanism of anemia in celiac disease were proposed the most common being abnormal iron absorption secondary to villous atrophy of the intestinal mucosa [7], increased blood loss, correlated with severity of villous atrophy and malabsorption of various micronutrient necessary for normal hematopoiesis. The involvement of some pro-inflammatory cytokine in celiac disease [8] such interferon gamma, interleukin 6 considered powerful mediators of hypoferremia in inflammation by synthesis of the iron regulatory hormone hepcidin are common in anemia of celiac disease.…”

Section: Discusionsmentioning

confidence: 99%

Severe Iron-deficiency Anemia and Celiac Disease

Claudia¹,

Buiga²,

Vlad³

et al. 2016

IJCD

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We report a case of a 37-year-old woman with atypical presentation of celiac disease in relation to severe iron-deficiency and hyperthyroidism. During the investigation for iron-deficiency anemia, after exclusion of hematologic disorders, she was diagnosed with celiac disease by small-bowel biopsy. After starting the gluten free diet, the serum hemoglobin values were corrected and the symptoms of hyperthyroidism improved. Our presentation demonstrates that for patients with severe iron-deficiency anemia, the examination for the celiac disease should be considered. The quality of life and morbidity of patients with hyperthyroidism, iron-deficiency anemia and celiac disease may be improved by gluten withdrawal.

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Immunological Approach of the Challenges of the XXI Century in Celiac Disease

Abstract: INTESTINAL INTRAEPITHELIAL LYMPHOCYTESSubclinical or latent cases of gluten-sensitive enteropathy were difficult to diagnose. Immunohistologic parameters showed that the numbers of CD3+ and CD8+ intraepithelial T-cells were much higher in histology-positive biopsies with (mean,

Cited by 5 publications

References 45 publications

Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Immunopathogenesis and therapeutic approaches in pediatric celiac disease

Severe Iron-deficiency Anemia and Celiac Disease

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