Immunological Deficiency Diseases

Hereditary Alterations in the Immune Response: Coexistence of ‘Agammaglobulinemia', Acquired Hypogammaglobulinemia and Selective Immunoglobulin Deficiency in a Sibship

“…The deficiency of the oldest boy best fits the clinical descriptions of congenital 'agammaglobulinemia' [8,31,34], since repeated infections began in infancy, the total and fractional immunoglobulin levels found were in the range generally described as characteristic for this entity [62], and a serum electrophoretic analysis at seven years of age revealed low or absent gamma globulins. In addition, the marked growth retardation and extent of lung disease noted when he was first seen by us indicated that his illness was chronic.…”

Antibody studies in hypogammaglobulinemia.

“…Serum immunoglobulins are detectable in the majority of individuals with even extreme hypogammaglobulinemia, and evidence of antibody formation has been found in some (1)(2)(3)(4)(5). It has been suggested that antibody production might be detectable in all hypogammaglobulinemic patients if sufficiently sensitive assay methods were employed (2).…”

Auto-Immunity Against IgG: Study of a Girl who had Undue Susceptibility to Infection and an IgM-IgG Euglobulin Complex in her Serum

“…BARANDUN et al [I], GOOD et al [5], and STOOP [22] do not refer to this cause in their reports on the antibody deficiency syndrome.…”