Immunological evidence of Zika virus transmission in Thailand

Wikan, Nitwara; Suputtamongkol, Yupin; Yoksan, Sutee; Smith, Duncan R.; Auewarakul, Prasert

doi:10.1016/j.apjtm.2016.01.017

Cited by 54 publications

(39 citation statements)

References 30 publications

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“…An alternative possibility is that these patients were previously exposed to ZIKV and thus had ZIKV-reactive antibodies in their sera as a result. In fact, in the past few years, isolated cases of ZIKV transmission in Thailand have been reported (10,19,20). Although there is no evidence of previous ZIKV epidemics in Thailand, the possibility that the patients in our study are ZIKVimmune and that the extensive cross-reactivity of their sera against ZIKV is due to preexisting ZIKV-induced antibodies cannot be formally ruled out.…”

Section: Discussionmentioning

confidence: 54%

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Priyamvada

Quicke

Hudson

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

509

482

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Zika virus (ZIKV) is an emerging mosquito-borne flavivirus of significant public health concern. ZIKV shares a high degree of sequence and structural homology compared with other flaviviruses, including dengue virus (DENV), resulting in immunological cross-reactivity. Improving our current understanding of the extent and characteristics of this immunological cross-reactivity is important, as ZIKV is presently circulating in areas that are highly endemic for dengue. To assess the magnitude and functional quality of cross-reactive immune responses between these closely related viruses, we tested acute and convalescent sera from nine Thai patients with PCRconfirmed DENV infection against ZIKV. All of the sera tested were cross-reactive with ZIKV, both in binding and in neutralization. To deconstruct the observed serum cross-reactivity in depth, we also characterized a panel of DENV-specific plasmablast-derived monoclonal antibodies (mAbs) for activity against ZIKV. Nearly half of the 47 DENV-reactive mAbs studied bound to both whole ZIKV virion and ZIKV lysate, of which a subset also neutralized ZIKV. In addition, both sera and mAbs from the dengue-infected patients enhanced ZIKV infection of Fc gamma receptor (FcγR)-bearing cells in vitro. Taken together, these findings suggest that preexisting immunity to DENV may impact protective immune responses against ZIKV. In addition, the extensive cross-reactivity may have implications for ZIKV virulence and disease severity in DENV-experienced populations. (2-4). However, the more recent outbreaks have caused severe neurological complications including GuillainBarré Syndrome in adults and an increase in congenital microcephaly and other adverse birth outcomes in Brazil (5-7). The Pan American Health Organization has reported that as of May 2016, local transmission of ZIKV had spread to over 38 countries or territories in the Americas. In addition, a recent WHO report states that 44 new countries are experiencing their first ZIKV outbreak since 2015. Despite the improving surveillance of the virus, accurate diagnosis has been challenging given the similarities in the clinical presentation of ZIKV to other arboviral infections endemic in these regions, among other factors.During the viremic period, ZIKV can be found in patient blood, saliva, urine, and other bodily fluids early after symptom onset (8-10). During the Yap Islands epidemic in 2007, anti-ZIKV IgM ELISAs and ZIKV plaque reduction neutralization titer (PRNT) assays were performed to confirm infection in RT-PCR negative cases (2, 8). However, as these studies showed, the cross-reactivity between ZIKV and other flaviviruses makes confirmation of infection difficult, especially when patients may have had flavivirus exposures before their suspected ZIKV infection (2,8). Given the overlapping presence of DENV and other flaviviruses in a majority of ZIKV epidemic regions (11), there are great challenges in serology-based testing of flavivirus-immune patients (12).The DENV envelope (E) protein, considered a major imun...

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Section: Discussionmentioning

confidence: 54%

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Priyamvada

Quicke

Hudson

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

509

482

View full text Add to dashboard Cite

show abstract

“…In the American continent,the most important Flavivirus are Dengue virus, Yellow fever virus, St Louis encephalitis virus, Japanese encephalitis virus, West Nile virus B David Baca-Carrasco davidbaca@im.unam.mx Jorge X. Velasco-Hernández jx.velasco@im.unam.mx and Zika virus (ZIKV), transmitted by Aedes mosquitoes but could be also transmitted by other species, for example, Culex (Duffy et al 2009;ECDC 2015;Hayes 2009;Tognarelli et al 2015;Wikan 2016;Yakoba and Walker 2016).…”

Section: Introductionmentioning

confidence: 99%

“…aegypti, Ae.albopictus, Ae.africanus, Ae.luteocephalus, Ae.vitattus, Ae.furcifer, Ae.hensilii and Ae.apicoargenteus (Duffy et al 2009;ECDC 2015;Hayes 2009;Tognarelli et al 2015;Wikan 2016;Yakoba and Walker 2016). In the United States,the more widespread mosquito is Ae.albopictus constituting a risk for Zika spread.…”

Section: Introductionmentioning

confidence: 99%

Sex, Mosquitoes and Epidemics: An Evaluation of Zika Disease Dynamics

Baca-Carrasco¹,

Hernández

2016

Bull Math Biol

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Since the first major outbreak reported on the island Yap in 2007, the Zika virus spread has alerted the scientific community worldwide. Zika is an arbovirus transmitted by Aedes mosquitoes; particularly in Central and South America, the main vector is the same mosquito that transmits dengue and chikungunya, Aedes aegypti. Seeking to understand the dynamics of spread of the Zika, in this paper, three mathematical models are presented, in which vector transmission of the virus, sexual contact transmission and migration are considered. Numerical analysis of these models allows us to have a clear view of the effects of sexual transmission and migration in the spread of the virus, showing that sexual transmission influences the magnitude of the outbreaks and migration generates outbreaks over time, each of lower intensity than the previous.

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“…These disease symptoms, which may persist for months or even years, are debilitating, causing fever, arthralgia or severe arthritis and itchy skin [9] . Zika virus is a flavivirus (Flaviviridae family) originally isolated in Uganda, in 1947 [10] . From 1951 to 2013, serological evidence in humans were notified in African countries (Uganda, Tanzania, Egypt, Central African Republic, Sierra Leone and Gabon), Asian countries (India, Malaysia, Philippines, Thailand, Vietnam and Indonesia) and Oceanian countries (Micronesia and French Polynesia).…”

Section: Introductionmentioning

confidence: 99%

“…Usually, infection is characterized by fever, skin rash, joint pain or conjunctivitis, that may last for days or weeks, and its . Dengue, chikungunya and zika are all transmitted by the same vector, Aedes aegypti mosquito [8,10,[14][15] . Because there are still no validated vaccines against dengue or a specific antiviral for treatment of those diseases [16][17][18] , the best control method is prevention, by attacking its vector [19] .…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization and Larvicidal Activity of Essential Oil from Aniba duckei Kostermans against Aedes aegypti

Teles¹,

Filho²,

Souza³

2017

IJLSSR

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ABSTRACT-Aedes aegypti mosquito is the major vector of zika, chikungunya, and dengue fever. These diseases incidence has been growing rapidly in many points of the globe in the past few years. And because there's no vaccine for them yet, the best way to fight those diseases is to attack their vector, specially by eliminating potential sites for its oviposition and larvae growth. Nowadays, organophosphorus insecticides are used in increasing doses, which targets Aedes aegypti resistant populations. Aniba duckei Kostermans, which is known as rosewood and belongs to the Lauraceae family, is a species with trees up to 30 meters tall and 1 meter in trunk diameter. It's essential oil is used in perfumery due to its high content of linalool. This research identified the components of essential oil from Aniba duckei Kostermans thin branches and leaves and then applied it as larvicide against Aedes aegypti, and its effects were measured by calculation of concentration at which half larvae die (LC 50 ). Average yield found for oil by plant was 1.93% by mass. The major component in rosewood essential oil is linalool, whose concentration was found 89.34% by mass. LC 50 for the essential oil was 250.61 (±2.20) µg mL -1 , for l-linalool, 279.89 (±2.12) µg mL -1 , and for dl-linalool was 346.73 (±2.14) µg mL -1 .

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Immunological evidence of Zika virus transmission in Thailand

Abstract: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation.

Cited by 54 publications

References 30 publications

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Sex, Mosquitoes and Epidemics: An Evaluation of Zika Disease Dynamics

Chemical Characterization and Larvicidal Activity of Essential Oil from Aniba duckei Kostermans against Aedes aegypti

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