Immunological methods for the diagnosis of oral mucosal diseases

Abstract

This summary relates to https://doi.

Genomic characterization of fourEscherichia colistrains isolated from oral lichen planus biopsies

“…OLP has been regarded as a chronic inflammatory disease with autoimmune features. Although the presence of serum autoantibodies against desmoglein ΙΙΙ or antinuclear antibodies has been reported in some OLP patients [55], no autoantigens targeted by the infiltrated T cells have been identified. Microbial infection can promote autoimmunity via molecular mimicry or bystander activation of self-reactive T cells [56].…”

Immunological diagnostic methods in oral mucosal diseases

“…This issue of BJD includes an extensive and practically useful review article by Sun et al ., which summarizes various immunological methods to diagnose the following seven major autoimmune and inflammatory diseases of the oral mucosa: pemphigus vulgaris, paraneoplastic pemphigus, mucous membrane pemphigoid (MMP), linear IgA bullous dermatosis (LABD), lichen planus pemphigoides, oral lichen planus (OLP) and oral discoid lupus erythematosus (DLE) . Although we have recently published a paper describing comprehensive diagnostic methods and current classification in autoimmune bullous diseases (AIBDs) in the BJD , the present article focuses on the diagnostic methods only for oral mucosal diseases, including two non‐AIBD diseases, OLP and oral DLE …”

“…Included are a large number of conventional and novel antigen molecules detected by various immunofluorescence (IF), immunoblotting and enzyme‐linked immunosorbent assay (ELISA) methods . Thus, this review article is very useful for both dentists and dermatologists engaged in practice for oral mucosal diseases, and also suggests the necessity of collaboration and team work between dentists and dermatologists …”

“…The usefulness of the protein microarray technique for AIBDs is also considered, particularly for the detection of novel autoantigens . However, when all the autoantigens are identified and ELISAs for these molecules are developed, the protein array technique may not be appropriate for the routine diagnosis for AIBDs, due to the high cost.…”

“…This article describes extensively and accurately the autoantigens, diagnostic methods and interpretation of the results for these diseases, with three well‐organized tables and 141 relevant references. Included are a large number of conventional and novel antigen molecules detected by various immunofluorescence (IF), immunoblotting and enzyme‐linked immunosorbent assay (ELISA) methods . Thus, this review article is very useful for both dentists and dermatologists engaged in practice for oral mucosal diseases, and also suggests the necessity of collaboration and team work between dentists and dermatologists …”