Immunological parameters in prophylactic sublingual immunotherapy in asymptomatic subjects sensitized to Japanese cedar pollen

Abstract

Prophylactic SLIT is effective for prevention of the development of pollinosis. Induction of IL-10 producing T cells, B cells and monocytes is an important mechanism of SLIT for prevention of pollinosis in asymptomatic but sensitized subjects.

Prophylactic Sublingual Immunotherapy for Japanese Cedar Pollinosis

“…The percentage of circulating IL-10 producing T cells and IL-10 producing monocytes significantly increased in the SLIT group in 2012 [5]. However, the number of IL-10 producing B cells remained unchanged [5]. The percentages of circulating IL-10 producing T cells and IL-10 producing B cells significantly increased in the sublingual immunotherapy group in 2013 [5].…”

“…In 2012, there was no significant difference in the ratio of symptom development between the sublingual immunotherapy group and the control group. However, in 2013, the ratio of the development of pollinosis in the sublingual immunotherapy group was significantly lower than that of the placebo group, which clearly indicates the efficacy of sublingual immunotherapy for the prevention of pollinosis development [5].…”

“…Yamanaka et al reported a clinical result of this trial which was conducted in Mie University in 2012 and 2013 [5]. 17 subjects participated in the study in each year.…”

“…Thus they have looked at changes of the percentage of IL-10-producing T cells, B cells and monocytes before (December) and after (April) the immunotherapy [5]. The percentage of circulating IL-10 producing T cells and IL-10 producing monocytes significantly increased in the SLIT group in 2012 [5]. However, the number of IL-10 producing B cells remained unchanged [5].…”

“…The increment in lL-10 production by monocytes, B cells and T cells during immunothearpy may influence effector cells involved in allergic responses. Thus they have looked at changes of the percentage of IL-10-producing T cells, B cells and monocytes before (December) and after (April) the immunotherapy [5]. The percentage of circulating IL-10 producing T cells and IL-10 producing monocytes significantly increased in the SLIT group in 2012 [5].…”