Immunological Parameters of Periparturient Holstein Cattle: Genetic Variation

Detilleux, Johann; Koehler, Kenneth J.; Freeman, A.E.; Kehrli, Marcus E.; Kelley, David H.

doi:10.3168/jds.s0022-0302(94)77205-2

Cited by 78 publications

(58 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cattle, heritabilities for intramammary infections varied from 0.02 to 0.04 as reported by Weller et al (1992). Somewhat higher (0.10-0.20) as quoted by Detilleux et al (1994) and Wanner et al (1998). In sheep, an estimate of 0.09 for the infection status assessed by bacteriological analyses was reported by Riggio et al (2010) and Tolone et al (2013) in the Valle del Belice breed.…”

Section: Genetic Parameters Of Scc and Mastitis In Sheepmentioning

confidence: 88%

Genetic selection for reduced somatic cell counts in sheep milk: A review

Riggio

Portolano

2015

Small Ruminant Research

View full text Add to dashboard Cite

a b s t r a c tMastitis is an inflammation of the udder, mainly caused by bacteria, and leads to economic loss, due to discarded milk, reduced milk production, reduced milk quality and increased health costs in both dairy sheep and cattle. Selecting for increased genetic resistance to mastitis can be done directly or indirectly, with the indirect selection corresponding to a prediction of the bacteriological status of the udder based on traits related to the infection. The most frequently used indirect method is currently milk somatic cell count (SCC) or somatic cell score (SCS). This review reports the state of the art relating to the genetic basis of mastitis resistance in sheep and explores the opportunities to use SCC as selection criterion in a breeding programme to improve resistance to mastitis in sheep, discussing the actual situation and prospects for improvement. It has been stressed, in particular, that although it is unlikely that selection for mastitis resistance by the farmers on their own will be successful, there is good prospect for genetic improvement if reliable pedigree and performance recording is implemented across flocks, combined with breeding value estimation. To achieve this, a strong and well-structured organization to implement and support the programme is essential.

show abstract

Section: Genetic Parameters Of Scc and Mastitis In Sheepmentioning

confidence: 88%

Genetic selection for reduced somatic cell counts in sheep milk: A review

Riggio

Portolano

2015

Small Ruminant Research

View full text Add to dashboard Cite

show abstract

“…Jacobsen et al (2005) showed that 60% of the variation in blood leukocyte counts after an LPS challenge could be attributed to the differences between individual cows. Detilleux et al (1994) demonstrated the heritable nature of these differences in immunological assays measured during the periparturient period.…”

Section: Stage 1: Model Developmentmentioning

confidence: 94%

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Detilleux

Vangroenweghe

Burvenich

2006

Journal of Dairy Science

View full text Add to dashboard Cite

We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10 4

show abstract

“…Different characteristics of peripheral PMN, such as stimulated CL activity, cytochrome c reduction, chemotaxis, and stimulated L-selectin and CD11b expression, have also been related to the severity. In addition, other pre-infection metabolic parameters in blood, such as b-hydroxybutyric acid, non-sterified fatty acids, glucose, Mg 2+ , Ca 2+ , cortisol, and cholesterol concentration, as well as in milk, such as SCC, albumin, fat, and casein production, have also been found to be associated with the severity of E. coliinduced mastitis [52,59,93,116,121,126,210,245,259]. Other studies have compared the functionality of PMN between early and later stages of lactation [158][159][160].…”

Section: Number and Function Of Circulating Pmnmentioning

confidence: 99%

Severity of E. coli mastitis is mainly determined by cow factors

et al. 2003

View full text Add to dashboard Cite

-Intramammary infections of dairy cows with Gram-positive bacteria such as Staphylococcus aureus (major cause of mastitis) have received a lot of attention because of their major economic impact on the dairy farm through production losses induced by an increase in somatic cell count. Management strategies, including greater awareness for efficient milking and hygienic measures, have limited the spread of Gram-positive bacteria and resulted in a significant decrease of proportion of S. aureus isolates and subclinical mastitis worldwide. Other organisms such as coliform subspecies and Streptococcus uberis, both environmental bacteria that cause clinical mastitis, have received less attention. Escherichia coli causes inflammation of the mammary gland in dairy cows around parturition and during early lactation with striking local and sometimes severe systemic clinical symptoms. This disease affects many high producing cows in dairy herds and may cause several cases of death per year in the most severe cases. It is well known that bacterial, cow and environmental factors are interdependent and influence mastitis susceptibility. Many studies, executed during the last decade, indicate that the severity of E. coli mastitis is mainly determined by cow factors rather than by E. coli pathogenicity. During E. coli mastitis, the host defense status is a cardinal factor determining the outcome of the disease. Today, we know that the neutrophil is a key factor in the cows' defense against intramammary infection with E. coli. Effective elimination of the pathogen by neutrophils is important for the resolution of infection and the outcome of E. coli mastitis. This review is a compilation of some major findings over the last 15 years concerning mainly host factors that modulate and influence neutrophil function and the mammary inflammatory reaction. The individual chapters address: virulence factors of E. coli strains, how neutrophils kill E. coli, connection between endotoxins, tumor necrosis factor-a and nitric oxide, severity classification of E. coli mastitis, lifespan of neutrophils, host factors that influence severity, tissue damage and production loss.

show abstract

Immunological Parameters of Periparturient Holstein Cattle: Genetic Variation

Cited by 78 publications

References 19 publications

Genetic selection for reduced somatic cell counts in sheep milk: A review

Genetic selection for reduced somatic cell counts in sheep milk: A review

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Severity of E. coli mastitis is mainly determined by cow factors

Contact Info

Product

Resources

About