Immunological studies in tropical splenomegaly syndrome in Uganda

Ziegler, John L.; Cohen, Martin H.; Hutt, M. S. R.

doi:10.1136/bmj.4.5674.15

Cited by 24 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are now numerous examples, the best of all perhaps being the hyperimmune situation in chronic endemic malaria, where considerable derangements of the immune system result from the hyperimmune state or are associated with the hyperimmune state. The deposition of immunoglobulin complexes in chronic malaria resulting in the nephrotic syndrome on the one hand (Kibukamusok, Hutt, and Wilks, 1967) and so-called big spleen disease or tropical splenomegaly on the other has certain interesting parallels with the situation beginning to emerge from some examples of the malignant process (Ziegler, Cohen, and Hutt, 1969). There could, therefore, be some interesting parallels in the study of immunity to parasites, such as the plasmodia, and circulating tumour cells.…”

Section: The Nephrotic Syndrome and Malignancymentioning

confidence: 99%

The role of circulating antibody in the control of metastases

Lewis¹

1974

Journal of Clinical Pathology

View full text Add to dashboard Cite

Section: The Nephrotic Syndrome and Malignancymentioning

confidence: 99%

The role of circulating antibody in the control of metastases

Lewis¹

1974

Journal of Clinical Pathology

View full text Add to dashboard Cite

“…1969), reduced haematocrit (Hamilton et al. 1967), leucopenia (Ziegler et al. 1969), macroglobulinaemia (Ziegler et al.…”

Section: Introductionmentioning

confidence: 99%

“…1967), leucopenia (Ziegler et al. 1969), macroglobulinaemia (Ziegler et al. 1969; Ziegler & Stuiver 1972), thrombocytopenia (Marsden et al.…”

Section: Introductionunclassified

See 1 more Smart Citation

Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trials

Ruzagira

Abaasa

Levin

et al. 2009

Tropical Medicine &Amp; International Health

View full text Add to dashboard Cite

Summaryobjectives To assess the degree of haematological and biochemistry abnormalities associated with splenomegaly in asymptomatic adults in order to determine whether they may be eligible for inclusion in HIV biomedical prevention trials.methods Asymptomatic adults (50% women) aged 18-60 with splenomegaly ( ‡grade II by Hackett's classification) who agreed to provide blood and urine specimens for laboratory testing were invited to participate in a cross-sectional study. Volunteers who were menstruating, pregnant, infected with HIV, syphilis or Hepatitis B and C, or had significant clinical findings were excluded. Haematological and biochemistry laboratory evaluations were performed for enroled volunteers, and the results were compared to local reference ranges. The proportion of volunteers with out-of-range (OOR) values was estimated for each parameter. Linear regression models were fitted to investigate the association between grade of splenomegaly and laboratory values.results The proportion of volunteers with OOR haematology values ranged from 4.5% (mean corpuscular volume) and 15% (CD4 cells) to 31% (basophils). Increasing spleen size was significantly associated with anaemia, thrombocytopenia and low CD4 count. OOR biochemistry values were found in about 10% of volunteers. Increasing spleen size was associated with reduced creatinine phosphokinase and creatinine (in men) and raised lactate dehydrogenase.conclusions In areas with a high prevalence of splenomegaly, most asymptomatic individuals with this condition have haematology and biochemistry values that fall within the local reference ranges, and they could therefore be eligible for inclusion in HIV biomedical prevention trials. However, the effect of splenomegaly on certain parameters should be taken into account during interpretation of laboratorybased adverse events.

show abstract

Surgical aspects of malaria

Gibney

1990

Journal of British Surgery

View full text Add to dashboard Cite

The spread of drug-resistant organisms and increased international travel makes malaria a disorder of ever-increasing importance. This report reviews those aspects of malaria of surgical relevance. The importance of the spleen in host defence against malaria and other infections makes splenic preservation desirable whenever possible after rupture of the spleen. Tropical splenomegaly is caused by an abnormal immune response to malaria and is best managed medically. Careful selection of blood donors is essential to prevent transfusion malaria, and routine antimalarial prophylaxis is indicated for blood recipients in many endemic areas. The risk of postoperative malaria may justify chemoprophylaxis in certain patients.

show abstract

Immunological studies in tropical splenomegaly syndrome in Uganda

Cited by 24 publications

References 11 publications

The role of circulating antibody in the control of metastases

The role of circulating antibody in the control of metastases

Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trials

Surgical aspects of malaria

Contact Info

Product

Resources

About