Immunology of hepatic diseases during pregnancy

Bremer, Lars; Schramm, Christoph; Tiegs, Gisa

doi:10.1007/s00281-016-0573-1

Cited by 21 publications

(16 citation statements)

References 208 publications

(194 reference statements)

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“…Liver disease in PE have a high risk of pregnancy disorder, although no reports of maternal death but the birth of premature infants [28]. Liver disorders in PE dieaseas may increase liver enzymes, autoimmune, hyperemesis gravidarum, acute fatty liver, and intrahepatic cholestasis [29]. This is in accordance with Emita’s study [30].…”

Section: Discussionsupporting

confidence: 67%

Effect of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology

Situmorang

Ilyas

Hutahaean

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Andaliman (Zanthoxylum acanthopodium) is a spice traditional Northen Sumatera, Indonesia and these fruits contain alkaloids, steroids and terpenoids. Extra Virgin Olive Oil (EVOO) contains antioxidants. Combination of this plant have activities to reduce preeclampsia. AIM: To know the safety of the combination of nano herbal andaliman and Extra virgin olive oil (EVOO) on preeclampsia patients’ liver. METHODS: Pregnant rats were made to have preeclampsia with 3 ml of NaCl 6% injections. This research consists of 5 groups: K- (negative control): normal pregnant rats, K+: preeclampsia rats; P1: PE rats were given nano herbal andaliman 1 ml EVOO / day / 20 gBW from the 13th to the 19th day of pregnancy, P2: PE rats were given nano herbal andaliman 100 mg/day / 200 gBW from the 13th to the 19th day of pregnancy, P3: PE was given the combination of 1 ml EVOO/day / 200 gBW and andaliman nano herbal 100 mg/day/200 gBW on the 13th day of pregnancy to the 19th day given orally. Then on the 20th day of pregnancy, the subjects were dissected. RESULTS: There were significant differences (p < 0.05) on the value of SGOT, SGPT, and the average damage of the hepatocyte cells except parenchymatous degeneration after being given the nano herbal andaliman and EVOO. The compared mean of normal hepatocytes cell, hydropic degeneration and necrosis value between all groups were p < 0.05 and p < 0.01 compared to (K-). The non-significant difference was found in the mean of parenchymatous degeneration between the groups (p = 0.058). CONCLUSION: The combination of nano herbal andaliman (Zanthoxylum acanthopodium) and EVOO affected the level of necrosis in hepatocyte cells on preeclampsia rats.

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Section: Discussionsupporting

confidence: 67%

Effect of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology

Situmorang

Ilyas

Hutahaean

et al. 2019

Open Access Maced J Med Sci

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“…ICP is defined as impairment of intrahepatic bile flow, resulting in retention in the liver and overflow into the blood. 20 ICP is the most common liver disease unique to pregnancy, yet shows geographic variation, being rare in North America and Southern Europe (1-2/1000 pregnancies), and common in South America and Scandinavia, where the prevalence is up to 10-fold higher. 1,3 Several adverse outcomes are associated with ICP, including preterm delivery, meconium-stained amniotic fluid, and fetal demise.…”

Section: Tablementioning

confidence: 99%

Liver disease in pregnancy

Sasamori¹,

Tanaka

Ayabe³

2020

Hepatology Research

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Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre‐eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Chronic liver diseases that affect pregnancy, or are affected by pregnancy, mainly include autoimmune liver diseases and non‐alcoholic fatty liver disease. Prompt diagnosis and management of liver diseases in pregnancy, while very challenging, is extremely important, as they might cause adverse maternal and fetal outcomes. Therefore, a multidisciplinary, collaborative approach involving both hepatologists and obstetricians is required. In this review article, the up‐to‐date epidemiology, etiology, clinical features, and outcomes of liver diseases in pregnancy are discussed, to promote a deeper understanding among physicians, and subsequently improved outcomes.

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“…For example, in PBC an enhanced X monosomy rate within PBMC, possibly T and B cells, compared to healthy women was found, while XCI was random and similar to the controls ( 131 – 133 ). Both PBC and AIH have their age peak of manifestation around menopause, and both show disease modulation by pregnancy with greatly reduced AIH activity during pregnancy and frequent flares after delivery, strongly suggesting the involvement of sex hormones ( 134 – 137 ). Deciphering these mechanisms may lead to novel therapeutic strategies for many of these diseases.…”

Section: Effects Of Androgens On T Cells In Autoimmunitymentioning

confidence: 99%

The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?

2020

Self Cite

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The immune system responds differently in women and in men. Generally speaking, adult females show stronger innate and adaptive immune responses than males. This results in lower risk of developing most of the infectious diseases and a better ability to clear viral infection in women (1-5). On the other hand, women are at increased risk of developing autoimmune diseases (AID) such as rheumatoid arthritis, multiple sclerosis (MS), systemic lupus erythematosus (SLE), Sjögren's syndrome, and the autoimmune liver diseases autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) (6). Factors contributing to the female sex bias in autoimmune diseases include environmental exposure, e.g., microbiome, behavior, and genetics including X chromosomal inactivation of genes. Several lines of evidence and clinical observations clearly indicate that sex hormones contribute significantly to disease pathogenesis, and the role of estrogen in autoimmune diseases has been extensively studied. In many of these diseases, including the autoimmune liver diseases, T cells are thought to play an important pathogenetic role. We will use this mini-review to focus on the effects of androgens on T cells and how the two major androgens, testosterone and dihydrotestosterone, potentially contribute to the pathogenesis of autoimmune liver diseases (AILD).

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Immunology of hepatic diseases during pregnancy

Cited by 21 publications

References 208 publications

Effect of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology

Effect of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology

Liver disease in pregnancy

The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?

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