Immunology of Sarcoidosis

Kataria, Yash P.; Holter, John F.

doi:10.1016/s0272-5231(05)70415-9

Cited by 98 publications

(58 citation statements)

References 88 publications

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“…Patients with sarcoidosis have a humoral immune system that is dysregulated and also have circulating autoantibodies, suggesting that they may be at increased risk for neutropenia that is drugdependent 34 We thank Barbara Roberts for performing the antineutrophil antibody assays. Figure 2 The patient's serum was incubated with NA1/NA1-(top) or NA2/NA2 (bottom)-typed donor cells in buffer or quinidine solutions.…”

Section: What Other Interventions Might Be Considered As Treatment Ofmentioning

confidence: 99%

Severe neutropenia: a diagnostic approach

Munshi

Montgomery

2000

Western Journal of Medicine

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Section: What Other Interventions Might Be Considered As Treatment Ofmentioning

confidence: 99%

Severe neutropenia: a diagnostic approach

Munshi

Montgomery

2000

Western Journal of Medicine

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“…A non-caseating epithelioid cell granuloma is the main pathological evidence of sarcoidosis (4). Variations in clinical manifestations, course and prevalence among different races and ethnic groups confi rm the heterogeneity of this disease (5). Sarcoidosis is more likely to occur among females in the fi fth decade of life.…”

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confidence: 99%

Sarcoidosis presenting as orbital pseudotumor

et al. 2015

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SUMMARYSarcoidosis is a systemic multiorgan disorder of unknown etiology characterized by a non-caseating granuloma reaction. Ocular involvement has been reported in 25-60% of the patients. Seven percent of the patients with sarcoidosis may first see an ophthalmologist due to ocular complaints. This report aims to present our diagnostic and treatment approach to a female patient with significant unilateral lacrimal gland swelling and musculoskeletal involvement, who was diagnosed with sarcoidosis on the basis of tests and histological studies.

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“…The inflammatory response is characterized by upregulation of Th1 CD4+ cells, causing increased production of IL-2, IFN-gamma and TNF-alpha, with resultant epithelioid granuloma formation. 7 Clinical manifestations of sarcoidosis vary based on degree and location of tissue involvement. Lung disease is seen in approximately 90% of patients with sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis as a Presentation of Sarcoidosis

Federman

Kirsner

2018

J of Skin

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Sarcoidosis is an idiopathic inflammatory disease characterized by granuloma formation in various tissues, most commonly the lungs, lymphatics, skin and eyes. Involvement of the breast in sarcoidosis is rare, and can be defined into three subsets, including granulomas localized to the breast, referred to as breast sarcoidosis. Breast sarcoidosis may present with systemic findings such as erythema nodosum, arthritis, and uveitis, and unlike typical sarcoidosis, commonly manifests during pregnancy. In this report, we present a rare case of breast sarcoidosis presenting in a pregnant female with associated erythema nodosum, arthralgias and ocular complaints.

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Immunology of Sarcoidosis

Cited by 98 publications

References 88 publications

Severe neutropenia: a diagnostic approach

Severe neutropenia: a diagnostic approach

Sarcoidosis presenting as orbital pseudotumor

Granulomatous Mastitis as a Presentation of Sarcoidosis

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