Immunology of Syphilis

Perine, Peter L.

doi:10.1007/978-1-4684-1009-9_16

Cited by 2 publications

(1 citation statement)

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“…The marked B cell responses of the congenitally infected fetus, noted by Silverstein in autopsy specimen in 1962, 5 and by our group in peripheral blood 30 years later, are likely to be the cause of the immunopathological effects associated with immune complexes involving antibodies and complement, and/or could be the result of other inflammatory responses. However, although cell‐mediated mechanisms have been postulated, 108 only one experimental study could be found in the literature on T cell responses in T. pallidum‐ infected and noninfected babies 109 . The workers observed no differences between the two groups in CD4 + and CD8 + T cell numbers or in lymphocyte transformation by phytohemagglutin.…”

Section: Evo‐devo and Practical Considerations On Stis Microbiota Agmentioning

confidence: 99%

Evolutionary–developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents

Nahmias

Schollin

Abramowsky

2011

Annals of the New York Academy of Sciences

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A balance has evolved over deep time between the various immune systems of the "triad" that is linked together for a short period: the pregnant woman, the fetus, and the placenta. This balance is affected by, and helps to determine, the immune responses to maternal infectious agents that may be transmitted to the fetus/infant transplacentally, intrapartum, or via breast milk. This review identifies newer evolutionary concepts and processes related particularly to the human placenta, innate and adaptive immune systems involved in tolerance, and in responses to sexually transmitted infectious (STI) agents that may be pathogenic to the fetus/infant at different gestational periods and in the first year of life. An evolutionary-developmental (EVO-DEVO) perspective has been applied to the complexities within, and among, the different actors and their beneficial or deleterious outcomes. Such a phylogenetic and ontogenic approach has helped to stimulate several basic questions and suggested possible explanations and novel practical interventions.

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Section: Evo‐devo and Practical Considerations On Stis Microbiota Agmentioning

confidence: 99%